Observations on the chemical nature of lead in human blood serum
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1. The binding of lead to human blood serum, and components of serum, was studied by titration with the addition of Pb(NO3)2 solution, monitoring the free Pb2+ concentration with a Pb2+ electrode, and by equilibrium dialysis. 2. In fresh serum, about 4999 out of 5000 parts of added lead were bound. This suggests that the free Pb2+ concentration is around 1/5000th of the total lead concentration in the serum of normal subjects, i.e. about 1 × 10−12 mol/l. 3. About 60% of the binding of lead in serum is abolished by standing in air, by dialysis or by treatment with N-ethylmaleimide. This appears to be due to the presence of thiol compounds, mainly cysteine. The remaining 40% appears to be due to protein, mainly albumin.
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1970 ◽
Vol 24
(03/04)
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pp. 334-337
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1960 ◽
Vol 12
(1)
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pp. 143-145
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2016 ◽
Vol 12
(4)
◽
pp. 349-356
1965 ◽
Vol 30
(9)
◽
pp. 3220-3226
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2021 ◽
pp. 119942