Enteric disease in Early Childhood Inhibits Microvillus Expression by Potential Stem Cells

1993 ◽  
Vol 84 (4) ◽  
pp. 377-379 ◽  
Author(s):  
M. Borg ◽  
A. D. Phillips ◽  
M. W. Smith ◽  
D. Brown
Keyword(s):  
Stem Cells ◽  
Early Childhood ◽  
Coeliac Disease ◽  
Milk Protein ◽  
Cow’S Milk ◽  
Healthy Children ◽  
Enteric Disease ◽  
Cow's Milk ◽  
Mature Adults ◽  
Protein Intolerance

1. Enterocyte development of microvillus structure has been measured in intestinal biopsies obtained from children suffering from coeliac disease, cow's milk protein intolerance and microvillus atrophy, and the results compared with similar measurements carried out in control children. 2. All types of enteric disease caused a significant 30% reduction in the length of microvilli present on undifferentiated basal crypt enterocytes, here referred to as potential stem cells. 3. Microvillus growth measured in control enterocytes took place mainly over the basal third of the villus. There was then little further change in structure during subsequent enterocyte migration to the villus tip. 4. Microvillus length in diseased tissue remained more or less constant during enterocyte migration to the crypt-villus junction. Microvillus length then decreased slightly during subsequent enterocyte migration over stunted villi. 5. The present results are discussed in relation to the supposed properties of potential stem cells. Comparisons are also made between profiles of microvillus development measured in healthy children and mature adults.

JEJUNAL BIOPSY IN COW'S MILK PROTEIN INTOLERANCE

The Lancet ◽  
1978 ◽  
Vol 311 (8066) ◽  
pp. 722-723 ◽  
Author(s):  
J.C Vitoria ◽  
M.E Aranjuelo ◽  
J Rodriguez-Soriano
Keyword(s):  
Milk Protein ◽  
Cow’S Milk ◽  
Jejunal Biopsy ◽  
Cow's Milk ◽  
Cow's Milk Protein Intolerance ◽  
Cow’S Milk Protein ◽  
Protein Intolerance

Cow's Milk Protein Intolerance

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 461-462
Author(s):  
HAROLD I. LECKS
Keyword(s):  
At Risk ◽  
Diagnostic Procedure ◽  
Milk Protein ◽  
Rectal Mucosa ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow's Milk Protein Intolerance ◽  
Cow’S Milk Protein ◽  
Pragmatic Aspects ◽  
Protein Intolerance

In Reply.— The literature has been replete with discussions of cow's milk protein hypersensitivity relevant to its diagnosis as well as clinical patterns of presentation since the entity was initially described by M. Rubin 40 years ago. Drs Gilbertson and Bentley now suggest a comparatively simple diagnostic procedure for detecting cow's milk protein intolerance (hypersensitivity) by merely inspecting the rectal mucosa of the infant at risk. My criticism of their observations relates initially to the specificity of rectal mucosal vascularity changes, as well as to the pragmatic aspects of this diagnostic procedure.

Cow's Milk Protein Intolerance

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 461-461
Author(s):  
NICOLA J. GILBERTSON ◽  
DONALD BENTLEY
Keyword(s):  
Milk Protein ◽  
Rectal Mucosa ◽  
Cow’S Milk ◽  
Clinical Feature ◽  
Cow's Milk ◽  
Cow's Milk Protein Intolerance ◽  
Cow’S Milk Protein ◽  
Protein Intolerance

To the Editor.— With regard to the diagnosis of cow's milk protein intolerance, we were interested by the findings of Kahn et al (Pediatrics 1985;76:880-884) and Dr Lecks' subsequent comments (Pediatrics 1986;78:378). A hitherto undescribed clinical feature that may contribute to the establishment of this diagnosis is the presence of hyperemia of the rectal mucosa in affected infants. Proctoscopy may readily be performed using a lubricated pediatric otoscope. The procedure is well tolerated, inexpensive, and takes only a few seconds.

scholarly journals 15 ANTICEN ABSORPTION IN CHILDREN WITH COW'S MILK PROTEIN INTOLERANCE

1988 ◽  
Vol 24 (3) ◽  
pp. 407-407
Author(s):  
M Heyman ◽  
E Crasset ◽  
R Ducroc ◽  
J F Desjeux
Keyword(s):  
Milk Protein ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow's Milk Protein Intolerance ◽  
Cow’S Milk Protein ◽  
Protein Intolerance
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