Search for non-invasive load-independent indices of left ventricular relaxation

2003 ◽  
Vol 105 (4) ◽  
pp. 395-397 ◽  
Author(s):  
Sherif F. NAGUEH

Echocardiography is an invaluable tool for the routine evaluation of patients with congestive heart failure. A number of Doppler modalities are now available. In this comment, the haemodynamic determinants and the clinical application of the more recent indices of left ventricular relaxation, namely tissue Doppler imaging of the mitral annulus and the flow propagation velocity by colour M-mode, and the importance of the study by Graham et al. in this issue of Clinical Science are discussed.

2012 ◽  
Vol 38 (9) ◽  
pp. 1461-1470 ◽  
Author(s):  
Yazine Mahjoub ◽  
Hélène Benoit-Fallet ◽  
Norair Airapetian ◽  
Emmanuel Lorne ◽  
Mélanie Levrard ◽  
...  

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Hyung-Kwan Kim ◽  
Keun-Ho Park ◽  
Suna-A Chang ◽  
Jin-Shik Park ◽  
Hyun-Jae Kang ◽  
...  

Background Growing use of the left ventricular(LV) systolic(LVSIsys) and diastolic synchronicity indexes(LVSIdia) in selecting potential responders to cardiac resynchronization therapy(CRT) has created a need for normative reference values. This study was performed to determine reference ranges for tissue Doppler imaging-derived LVSIsys and LVSIdia, and to assess their relationships to age and conventional parameters reflecting LV systolic and diastolic functions. Methods and Results We recruited 160 completely healthy volunteers (45±13yrs, 104 men) free of any systemic or cardiovascular disease. Maximal difference and SD of time to peak systolic and early diastolic velocities for LVSIsys and LVSIdia were measured using 6- and 12-segment models. Table and Figure represent normal ranges. Aging was not found to significantly change LVSIsys, whereas LVSIdia progressively and consistently increased with age. Significant correlations were observed between LVSIdia and parameters representing LV diastolic function, i.e. early mitral inflow velocity and its deceleration time, and early mitral annulus velocity. A physiologic rise in LV mass/Ht 2.7 showed a weak, but significant correlation with LVSIdia( r = 0.15 to 0.22), but not with LVSIsys. On multivariate analysis, age-dependent increase in LVSIdia was confirmed. Conclusions Age-specific reference ranges for LVSIsys and LVSIdia are presented here. LVSIsys remain stable throughout age groups, whereas LVSIdia progressively increases with age. These data given here will be useful for defining abnormal LV synchronous contraction and relaxation, and help better select patients likely to respond favorably to CRT.


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