scholarly journals Human placental villous stromal extracellular matrix regulates fetoplacental angiogenesis in severe fetal growth restriction

2021 ◽  
Author(s):  
Shuhan Ji ◽  
Diane Gumina ◽  
Kathryn McPeak ◽  
Radu Moldovan ◽  
Miriam D Post ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Euclidean Distance ◽  
Growth Restriction ◽  
Matrix Interactions ◽  
Significant Impairment ◽  
Stromal Matrix ◽  
Control Matrix ◽  
Novel Model

Pregnancies complicated by severe, early-onset fetal growth restriction with abnormal Doppler velocimetry (FGRadv) have a sparse villous vascular tree secondary to impaired angiogenesis. As endothelial cell (EC) and stromal matrix interactions are key regulators of angiogenesis, we investigated the role of placental stromal villous matrix on fetoplacental EC angiogenesis. We have developed a novel model of generating placental fibroblast (FB) cell-derived matrices (CDM), allowing us to interrogate placental-specific human EC and stromal matrix interactions and their effects on fetoplacental angiogenesis. We found that as compared to control ECs plated on control matrix, FGRadv ECs plated on FGRadv matrix exhibited severe migrational defects, as measured by velocity, directionality, accumulated distance, and Euclidean distance in conjunction with less proliferation. However, control ECs, when interacting with FGRadv CDM, also demonstrated significant impairment in proliferation and migratory properties. Conversely several angiogenic attributes were rescued in FGRadv ECs subjected to control matrix, demonstrating the importance of placental villous stromal matrix and EC-stromal matrix interactions in regulation of fetoplacental angiogenesis.

scholarly journals The Role of HLAC and NK Cells in Fetal Growth Restriction

2017 ◽  
pp. 142
Author(s):  
Sri Sulistyawati ◽  
Didon M Trimulya ◽  
Supriyadi H Respati ◽  
Soetrisno Soetrisno
Keyword(s):  
Nk Cells ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Nk Cell ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Immunohistochemical Method ◽  
Cross Sectional ◽  
The Mean

Objective: To determine the role of HLA-C and NK cell expressions in fetal growth restriction (FGR). Methods: A cross sectional study design was used. This study was conducted at the Obstetrics and Gynecology Department of Dr. Moewardi General Hospital, Surakarta, its affiliated hospitals, and at the Pathological Anatomy Laboratory of the Faculty of Medicine, University of Sebelas Maret Surakarta. A total of 40 samples were included in this study. The samples consisted of 20 normal pregnancies and 20 pregnancies with FGR. HLA-C expression in the trophoblast and NK cells in decidua of the subjects who met the inclusion and exclusion criteria were examined using immunohistochemical method and statistical analysis with T test. Results: The mean expression of HLA-C in the trophoblast in the pregnant group with FGR was 9.021.30, normal pregnancy was 7.96 ± 0.97, p=0.01 (p<0.05). The mean expression of NK cells in decidua of pregnancy with FGR was 10.59 ± 2.11, normal pregnancy was 0.91 ± 8.18, with p=0.00 (p<0.05). Conclusion: The expressions of HLA-C in trophoblast and NK cells in decidua of pregnancy with FGR were higher compared with those of normal pregnancy. [Indones J Obstet Gynecol 2017; 5-3: 142-148] Keywords: fetal growth restriction, HLA-C, NK cells

737: Expectant management of severe preterm preeclampsia: Role of fetal growth restriction on outcomes

2007 ◽  
Vol 197 (6) ◽  
pp. S209
Author(s):  
Silvia Malberti ◽  
Maddalena Incerti ◽  
Anna Locatelli ◽  
Sara Consonni ◽  
Massimiliano Greco ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Expectant Management ◽  
Growth Restriction

Role of Color Doppler in Fetal Growth Restriction & Its Fetal Outcome: A Prospective Study

2019 ◽  
Vol 10 (8) ◽  
pp. 296
Author(s):  
Tanu Bhati ◽  
Rajni Agarwal ◽  
R.C Purohit ◽  
Subhash Chand Sylonia ◽  
Kalpana Verma ◽  
...  
Keyword(s):  
Prospective Study ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Color Doppler ◽  
Fetal Outcome ◽  
Growth Restriction ◽  
A Prospective Study

Role of ADAMTS5 in Unexplained Fetal Growth Restriction (FGR)

2016 ◽  
Vol 35 (4) ◽  
pp. 220-230 ◽  
Author(s):  
Sibel Ozler ◽  
Efser Oztas ◽  
Basak Gumus Guler ◽  
Sultan Pehlivan ◽  
Nezaket Kadioglu ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction

The Role of Aspirin Dose on the Prevention of Preeclampsia and Fetal Growth Restriction

2017 ◽  
Vol 37 (1) ◽  
pp. 9
Author(s):  
S. Roberge ◽  
K. Nicolaides ◽  
S. Demers ◽  
J. Hyett ◽  
N. Chaillet ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Aspirin Dose

scholarly journals The role of melatonin in pregnancies complicated by placental insufficiency: a systematic review

2021 ◽  
Author(s):  
Ilaria Fantasia ◽  
Sofia Bussolaro ◽  
Tamara Stampalija ◽  
Daniel Rolnik
Keyword(s):  
Oxidative Stress ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Evidence Synthesis ◽  
Placental Insufficiency ◽  
Growth Restriction ◽  
Melatonin Receptors ◽  
Qualitative Evidence Synthesis ◽  
Melatonin Administration

Background: Pregnancies complicated by placental insufficiency are characterised by increased oxidative stress. It has been suggested that melatonin has antioxidant properties and contributes to the maintenance of placental homeostasis. Objective: To systematically review the available literature about melatonin in pregnancies complicated by placental insufficiency, specifically preeclampsia and fetal growth restriction, exploring three different aspects: 1) maternal melatonin levels; 2) expression and activity of melatonin placental receptors; 3) effects of maternal melatonin administration. Search strategy: PubMed (Medline) and Scopus were searched until December 2020. Selection criteria: Published literature in English language describing the role of melatonin in pregnancies complicated by placental insufficiency, with a specific focus on preeclampsia and fetal growth restriction. Data collection and analysis: Identified studies were screened and assessed independently by two authors. Data were extracted and compiled in a qualitative evidence synthesis. Main results: Pregnancies complicated by placental insufficiency show a significant reduction in maternal systemic serum melatonin levels and a significant reduction in the expression of placental melatonin receptors. Melatonin administration in pregnancy seems safe and may reduce oxidative stress. Conclusion: The circadian pattern of melatonin secretion seems to be altered in pregnancies complicated by placental insufficiency. This is reflected by lower production of melatonin, with consequent lower systemic and placental concentrations, and lower expression of melatonin receptors, thus reducing the local release of the indole and its autocrine function. Funding: None Keywords: Melatonin, Preeclampsia, Fetal growth restriction, Placental insufficiency, Review.

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