Recent Breakthroughs in Alzheimer's Disease: Risk Factors, Biological Markers, Cognitive and Linguistic Distinctions, and Pharmacological Interventions

1997 ◽  
Vol 7 (4) ◽  
pp. 4-5
Author(s):  
Sandra Bond Chapman
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Markers ◽  
Disease Risk ◽  
Pharmacological Interventions

scholarly journals Interactions between inflammation, sex steroids, and Alzheimer’s disease risk factors

2016 ◽  
Vol 43 ◽  
pp. 60-82 ◽  
Author(s):  
Mariana F. Uchoa ◽  
V. Alexandra Moser ◽  
Christian J. Pike
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Steroids ◽  
Disease Risk

scholarly journals Microglia in Alzheimer's Disease: Risk Factors and Inflammation

2018 ◽  
Vol 9 ◽  
Author(s):  
Atsuko Katsumoto ◽  
Hideyuki Takeuchi ◽  
Keita Takahashi ◽  
Fumiaki Tanaka
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Risk

An efficient biosensor for monitoring Alzheimer's disease risk factors: modulation and disaggregation of the Aβ aggregation process

2019 ◽  
Vol 7 (26) ◽  
pp. 4124-4132 ◽  
Author(s):  
Siyue Ma ◽  
Jiabao Qiang ◽  
Linyang Li ◽  
Yan Mo ◽  
Mengyao She ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Risk ◽  
Aggregation Process ◽  
Aβ Aggregation

An efficient biosensor to monitor Alzheimer's disease risk factors and inhibit Alzheimer's disease by disaggregating Aβ aggregation.

Use of aripiprazole for psychosis and agitation in dementia

2005 ◽  
Vol 18 (2) ◽  
pp. 335-340 ◽  
Author(s):  
Jerson Laks ◽  
Roberto Miotto ◽  
Valeska Marinho ◽  
Eliasz Engelhardt
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Elderly Woman ◽  
Marked Decrease ◽  
Disease Risk ◽  
Complete Recovery ◽  
Neuropsychiatric Inventory

We report the case of an elderly woman with Alzheimer's disease, risk factors for vascular dementia, and atrium-ventricular blockade, who presented with severe agitation and psychosis. She was treated with aripiprazole and assessed with the Neuropsychiatric Inventory (NPI) over the course of 14 weeks. NPI scores showed a marked decrease in psychosis and agitation at week 4, and complete recovery at week 14, except for depression.

scholarly journals FMNL2 interacts with cerebrovascular risk factors to alter Alzheimer's disease risk

2020 ◽  
Author(s):  
Neha Raghavan ◽  
Sanjeev Sariya ◽  
Annie Lee ◽  
Yizhe Gao ◽  
Dolly Reyes-Dumeyer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Risk ◽  
Late Onset ◽  
Major Pathway ◽  
Cerebrovascular Risk Factors ◽  
Interaction Factor ◽  
Gene Level ◽  
Cerebrovascular Risk

INTRODUCTION: Late-onset Alzheimer's disease (AD) frequently co-occurs with cerebrovascular disease. We hypothesized that interactions between genes and cerebrovascular risk factors (CVRFs) contribute to AD risk. METHODS: Participants age 65 years or older from five multi-ethnic cohorts (N=14,669) were included in genome-wide association meta-analyses for AD including an interaction factor for a CVRF score created from body mass index, hypertension, heart disease, and diabetes. Significant gene level results were substantiated using neuropathological and gene expression data. RESULTS: At the gene-level, FMNL2 interacted with the CVRF score to significantly modify AD risk (p= 7.7x10-7). A SNP within FRMD4B, rs1498837, was nominally significant (p=7.95x10-7). Increased FMNL2 expression was significantly associated with brain infarcts and AD. DISCUSSION: FMNL2 is highly expressed in the brain and has been associated with ischemic stroke and failures in endosomal trafficking, a major pathway in AD pathology. The results highlight an interaction between FMNL2 and CVRFs on AD susceptibility.

Amla Therapy as a Potential Modulator of Alzheimer’s Disease Risk Factors and Physiological Change

2020 ◽  
Vol 74 (3) ◽  
pp. 713-733
Author(s):  
Elham Teimouri ◽  
Stephanie R. Rainey-Smith ◽  
Prashant Bharadwaj ◽  
Giuseppe Verdile ◽  
Ralph N. Martins
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Risk ◽  
Physiological Change
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