Prospective randomized double-blind placebo-controlled trial of glyceryl trinitrate in endoscopic retrograde cholangiopancreatography-induced pancreatitis

2001 ◽  
Vol 88 (9) ◽  
pp. 1178-1182 ◽  
Author(s):  
S. Sudhindran ◽  
E. Bromwich ◽  
P. R. Edwards
Keyword(s):  
Glyceryl Trinitrate ◽  
Endoscopic Retrograde Cholangiopancreatography ◽  
Controlled Trial ◽  
Endoscopic Retrograde ◽  
Double Blind ◽  
Double Blind Placebo

Intramuscular diclofenac for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A randomized, double-blind, placebo-controlled trial

Pancreatology ◽  
2014 ◽  
Vol 14 (3) ◽  
pp. S22-S23
Author(s):  
Se Woo Park ◽  
Moon Jae Chung ◽  
Jeong Youp Park ◽  
Seungmin Bang ◽  
Seung Woo Park ◽  
...  
Keyword(s):  
Endoscopic Retrograde Cholangiopancreatography ◽  
Controlled Trial ◽  
Endoscopic Retrograde ◽  
Double Blind ◽  
Double Blind Placebo

Sa1799 Intramuscular Diclofenac for the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Randomized, Double-Blind, Placebo-Controlled Trial

2014 ◽  
Vol 146 (5) ◽  
pp. S-298
Author(s):  
Se Woo Park ◽  
Moon Jae Chung ◽  
Tak Geun Oh ◽  
Jeong Youp Park ◽  
Seungmin Bang ◽  
...  
Keyword(s):  
Endoscopic Retrograde Cholangiopancreatography ◽  
Controlled Trial ◽  
Endoscopic Retrograde ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial

2016 ◽  
Vol 81 (3) ◽  
pp. 141-148
Author(s):  
B. Hernández-Velázquez ◽  
C.R. Camara-Lemarroy ◽  
J.A. González-González ◽  
D. García-Compean ◽  
R. Monreal-Robles ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Endoscopic Retrograde Cholangiopancreatography ◽  
Controlled Trial ◽  
Acute Inflammatory Response ◽  
Endoscopic Retrograde ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Can topical epinephrine application to the papilla prevent pancreatitis after endoscopic retrograde cholangiopancreatography? Results from a double blind, multicentre, placebo controlled, randomised clinical trial

2021 ◽  
Vol 8 (1) ◽  
pp. e000562
Author(s):  
Adriana Fabiola Romano-Munive ◽  
J Jesus García-Correa ◽  
Luis F García-Contreras ◽  
José Ramírez-García ◽  
Luis Uscanga ◽  
...  
Keyword(s):  
Endoscopic Retrograde Cholangiopancreatography ◽  
Controlled Trial ◽  
Randomised Clinical Trial ◽  
Sterile Water ◽  
Endoscopic Retrograde ◽  
Double Blind ◽  
Registration Number ◽  
Baseline Characteristics ◽  
Randomised Controlled ◽  
Rectal Indomethacin

Background and study aimsPost-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a complication associated with important morbidity, occasional mortality and high costs. Preventive strategies are suboptimal as PEP continues to affect 4% to 9% of patients. Spraying epinephrine on the papilla may decrease oedema and prevent PEP. This study aimed to compare rectal indomethacin plus epinephrine (EI) versus rectal indomethacin plus sterile water (WI) for the prevention of PEP.Patients and methodsThis multicentre randomised controlled trial included patients aged >18 years with an indication for ERCP and naive major papilla. All patients received 100 mg of rectal indomethacin and 10 mL of sterile water or a 1:10 000 epinephrine dilution. Patients were asked about PEP symptoms via telephone 24 hours and 7 days after the procedure. The trial was stopped half way through after a new publication reported an increased incidence of PEP among patients receiving epinephrine.ResultsOf the 3602 patients deemed eligible, 3054 were excluded after screening. The remaining 548 patients were randomised to EI group (n=275) or WI group (n=273). The EI and WI groups had similar baseline characteristics. Patients in the EI group had a similar incidence of PEP to those in the WI group (3.6% (10/275) vs 5.12% (14/273), p=0.41). Pancreatic duct guidewire insertion was identified as a risk factor for PEP (OR 4.38, 95% CI (1.44 to 13.29), p=0.009).ConclusionSpraying epinephrine on the papilla was no more effective than rectal indomethacin alone for the prevention of PEP.Trial registration numberThis study was registered with ClinicalTrials.gov (NCT02959112).

A prospective, randomized, double-blind, placebo-controlled trial of glyceryl-trinitrate ointment in the treatment of children with anal fissure

1999 ◽  
Vol 34 (12) ◽  
pp. 1810-1812 ◽  
Author(s):  
B Tander ◽  
A Güven ◽  
S Demirbaǧ ◽  
Y Özkan ◽  
H Öztürk ◽  
...  
Keyword(s):  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Glyceryl Trinitrate Ointment
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