scholarly journals The release of leukotriene B4 from human skin in response to substance P: evidence for the functional heterogeneity of human skin mast cells among individuals

2001 ◽  
Vol 124 (1) ◽  
pp. 150-156 ◽  
Author(s):  
T. Okabe ◽  
M. Hide ◽  
O. Koro ◽  
N. Nimi ◽  
S. Yamamoto
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Human Skin ◽  
Leukotriene B4 ◽  
Functional Heterogeneity

Human Skin Mast Cells Produce TNF-α by Substance P

1998 ◽  
Vol 117 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Yoshimichi Okayama ◽  
Yoshihiro Ono ◽  
Tsugio Nakazawa ◽  
Martin Church ◽  
Masatomo Mori
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Human Skin ◽  
Tnf Α

The substance P receptor on rat mast cells and in human skin

1984 ◽  
Vol 14 (3-4) ◽  
pp. 420-424 ◽  
Author(s):  
W. Piotrowski ◽  
M. A. B. Devoy ◽  
C. C. Jordan ◽  
J. C. Foreman
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Human Skin ◽  
Substance P Receptor ◽  
Rat Mast Cells

Immunolocalization of substance P in human skin mast cells

2000 ◽  
Vol 292 (8) ◽  
pp. 418-421 ◽  
Author(s):  
M. Toyoda ◽  
Teruhiko Makino ◽  
Masayori Kagoura ◽  
Masaaki Morohashi
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Human Skin

Mast cell-nerve fiber interaction: Ultrastructural studies

1990 ◽  
Vol 48 (3) ◽  
pp. 428-429
Author(s):  
E.Y. Chi ◽  
M.L. Su ◽  
Y.T. Tien ◽  
W.R. Henderson
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Substance P ◽  
Nerve Fiber ◽  
Sensory Nerves ◽  
Ultrastructural Studies ◽  
Morphological Studies ◽  
Granulocyte Infiltration ◽  
Intracutaneous Injection ◽  
Recent Attention

Recent attention has been directed to the interaction of the nerve and immune systems. The neuropeptide substance P, a tachykinnin which is a neurotransmitter in the central and peripheral nervous systems produces tissue swelling, augemntation of intersitial fibrin deposition and leukocyte infiltration after intracutaneous injection. There is a direct correlation reported between the extent of mast cell degranulation at the sites of injection and the tissue swelling or granulocyte infiltration. It has previously been demonstrated that antidromic electrical stimulation of sensory nerves induces degranulation of cutaneous mast cells, cutaneous vasodilation and augmented vascular permeability. Morphological studies have documented a close anatiomical association between mast cells and nonmyelinated nerves, that contain substance P and other neuropeptides. However, the presence of mast cells within nerve fasicles has not been previously examined ultrastructurally. In this study, we examined ultrastructurally the distribution of mast cells in the nerve fiber bundles located in the muscular connective tissue of rat tongues (n=20).

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