Intranasal immunization with yeast‐expressed 19 kD carboxyl‐terminal fragment ofPlasmodium yoeliimerozoite surface protein‐1 (yMSP119) induces protective immunity to blood stage malaria infection in mice

1998 ◽  
Vol 20 (9) ◽  
pp. 413-420 ◽  
Author(s):  
CHAKRIT HIRUNPETCHARAT ◽  
DANIELLE STANISIC ◽  
XUE QIN LIU ◽  
JIM VADOLAS ◽  
RICHARD A. STRUGNELL ◽  
...  
Keyword(s):  
Malaria Infection ◽  
Protective Immunity ◽  
Surface Protein ◽  
Blood Stage ◽  
Intranasal Immunization ◽  
Terminal Fragment ◽  
Carboxyl Terminal ◽  
Blood Stage Malaria

Biosynthesized silver nanoparticles protect against hepatic injury induced by murine blood-stage malaria infection

2020 ◽  
Vol 27 (15) ◽  
pp. 17762-17769 ◽  
Author(s):  
Mohamed A. Dkhil ◽  
Rewaida Abdel-Gaber ◽  
Ghada Alojayri ◽  
Esam M. Al-Shaebi ◽  
Mahmood A. A. Qasem ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Malaria Infection ◽  
Hepatic Injury ◽  
Blood Stage ◽  
Blood Stage Malaria

scholarly journals Roles of IFN-γ and γδ T Cells in Protective Immunity Against Blood-Stage Malaria

2013 ◽  
Vol 4 ◽  
Author(s):  
Shin-Ichi Inoue ◽  
Mamoru Niikura ◽  
Shoichiro Mineo ◽  
Fumie Kobayashi
Keyword(s):  
T Cells ◽  
Protective Immunity ◽  
Γδ T Cells ◽  
Blood Stage ◽  
Ifn Γ ◽  
Blood Stage Malaria

scholarly journals PD-1 Deficiency Enhances Humoral Immunity of Malaria Infection Treatment Vaccine

2015 ◽  
Vol 83 (5) ◽  
pp. 2011-2017 ◽  
Author(s):  
Taiping Liu ◽  
Xiao Lu ◽  
Chenghao Zhao ◽  
Xiaolan Fu ◽  
Tingting Zhao ◽  
...  
Keyword(s):  
B Cells ◽  
Humoral Immunity ◽  
Malaria Infection ◽  
Protective Immunity ◽  
Malaria Parasite ◽  
Protective Efficacy ◽  
Underlying Mechanism ◽  
Blood Stage ◽  
Infection Treatment ◽  
New Evidence

Malaria infection treatment vaccine (ITV) is a promising strategy to induce homologous and heterologous protective immunity against the blood stage of the parasite. However, the underlying mechanism of protection remains largely unknown. Here, we found that a malaria-specific antibody (Ab) could mediate the protective immunity of ITV-immunized mice. Interestingly, PD-1 deficiency greatly elevated the levels of both malaria-specific total IgG and subclass IgG2a and enhanced the protective efficacy of ITV-immunized mice against the blood-stage challenge. A serum adoptive-transfer assay demonstrated that the increased Ab level contributed to the enhanced protective efficacy of the immunized PD-1-deficient mice. Further study showed that PD-1 deficiency could also promote the expansion of germinal center (GC) B cells and malaria parasite-specific TFHcells in the spleens of ITV-immunized mice. These results suggest that PD-1 deficiency improves the protective efficacy of ITV-immunized mice by promoting the generation of malaria parasite-specific Ab and the expansion of GC B cells. The results of this study provide new evidence to support the negative function of PD-1 on humoral immunity and will guide the design of a more effective malaria vaccine.

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