Merkel cell carcinoma and multiple cutaneous squamous cell carcinomas in a patient with pityriasis rubra pilaris

2002 ◽  
Vol 43 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Nghi T Huynh ◽  
Michelle J Hunt ◽  
Adrian R Cachia ◽  
Michael J Veness
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Merkel Cell ◽  
Pityriasis Rubra Pilaris

scholarly journals Merkel Cell Carcinoma of the Head in a Young African Albino Woman with HIV/HTLV-1 Coinfection Associated with Multiple Squamous Cell Carcinomas

2019 ◽  
Vol 11 (1) ◽  
pp. 113-122
Author(s):  
Daniela Tenea ◽  
Jurgen Dinkel ◽  
Jurgen C. Becker ◽  
Elisabeth van der Walt
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Squamous Cell ◽  
Sun Exposure ◽  
Squamous Cell Carcinomas ◽  
Sub Saharan Africa ◽  
Merkel Cell ◽  
Skin Cancers ◽  
Sub Saharan ◽  
B Lymphoid

Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm of presumed neuroendocrine origin, with aggressive behavior and poor prognosis, that tends to have an increased incidence among elderly Caucasians and immunosuppressed individuals. MCC is either associated with a clonal integration of the Merkel cell polyoma virus into the host genome or with genomic alterations caused by chronic UV exposure. Tumors of either carcinogenesis show epithelial, neuroendocrine, and B-lymphoid lineage markers. HIV-infected African albinos have a higher risk of developing skin cancers, including MCC, in comparison with the general population. We report a case of MCC of the head in a young albino woman with a HIV/HTLV-1 coinfection. The patient also suffered from multiple squamous cell carcinomas of the scalp, face, lip, and ears, suggesting an UV carcinogenesis of MCC. The purpose of this case report is to emphasize the relationship between immunosuppression (HIV/HTLV-1 coinfection, chronic sun exposure, ocular-cutaneous albinism, pregnancy) and MCC. It highlights the importance of early diagnosis, dermatological screening with a risk-stratified surveillance, particularly in immunosuppressed albino patients in sub-Saharan Africa, and multidisciplinary management of this biologically unique cutaneous cancer.

Concurrent Merkel cell carcinoma and squamous cell carcinoma in a chest nodule

2015 ◽  
Vol 25 (5) ◽  
pp. 492-494
Author(s):  
Misaki Takahashi ◽  
Hidetsugu Fukuda ◽  
Yuki Yokouchi ◽  
Yumiko Hashida ◽  
Masanori Daibata ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Squamous Cell ◽  
Merkel Cell

scholarly journals Clinical and dermoscopic features of combined cutaneous squamous cell carcinoma (SCC)/neuroendocrine [Merkel cell] carcinoma (MCC)

2015 ◽  
Vol 73 (6) ◽  
pp. 968-975 ◽  
Author(s):  
Andrea Luísa Suárez ◽  
Peter Louis ◽  
Jasmine Kitts ◽  
Klaus Busam ◽  
Patricia L. Myskowski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Merkel Cell
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