scholarly journals Second Primary Cancers in Patients with Invasive and In Situ Squamous Cell Skin Carcinoma, Kaposi Sarcoma, and Merkel Cell Carcinoma: Role for Immune Mechanisms?

2020 ◽  
Vol 140 (1) ◽  
pp. 48-55.e1 ◽  
Author(s):  
Subhayan Chattopadhyay ◽  
Akseli Hemminki ◽  
Asta Försti ◽  
Kristina Sundquist ◽  
Jan Sundquist ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Squamous Cell ◽  
Kaposi Sarcoma ◽  
Second Primary ◽  
Skin Carcinoma ◽  
Merkel Cell ◽  
Second Primary Cancers ◽  
Squamous Cell Skin Carcinoma

Squamous Cell Carcinoma In Situ Overlying Merkel Cell Carcinoma

2016 ◽  
Vol 20 (6) ◽  
pp. 563-566 ◽  
Author(s):  
Maria A. McGowan ◽  
Matthew F. Helm ◽  
Michelle B. Tarbox
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Presentation ◽  
Merkel Cell ◽  
The Past ◽  
Exponential Increase ◽  
Worse Prognosis

Background:Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neoplasm that has exhibited an exponential increase in incidence in the past 3 decades. Combined MCC and cutaneous squamous cell carcinoma (SCC/MCC) is an uncommon variant of MCC that exhibits worse prognosis than pure MCC.Objective:To describe the clinical presentation, dermoscopy, and histology of an unusual subtype of combined SCC/MCC.Methods and Results:A 73-year-old white woman presented with an ulcerated and violaceous 10-mm plaque on her right jawline that had been present for 2 to 3 months. On dermoscopy, the lesion was predominantly milky pink to red with peripheral crusting and large-caliber polymorphous vessels. Histology revealed SCC in situ above and adjacent to MCC. The tumor was excised with clear margins, and sentinel lymph node scintography was negative for nodal involvement.

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