Intracellular and Plasma Magnesium in Familial Hemiplegic Migraine and Migraine With and Without Aura

Familial hemiplegic migraine (FHM) is an autosomal dominant type of migraine and probably represents the most extreme end of migraine with aura. Reduced magnesium facilitates the development of spreading depression and possibly aura. Cellular magnesium levels are under genetic control. We hypothesized that FHM patients would have significantly reduced intracellular magnesium levels. We determined intracellular and plasma magnesium levels in blood of 38 afflicted and 11 non-afflicted members of three families with FHM and, in 32 migraine patients (9 with and 23 without aura) and 32 age and sex matched healthy controls. We found no significant differences between the magnesium levels in the five study groups. We conclude that reduced blood magnesium is unlikely to be related to migraine pathophysiology.

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Widespread c-Fos expression after cortical spreading depression; possible differences between two types of animal models of familial hemiplegic migraine 2

Journal of the Neurological Sciences ◽

10.1016/j.jns.2017.08.2666 ◽

2017 ◽

Vol 381 ◽

pp. 947

Author(s):

M. Unekawa ◽

K. Ikeda ◽

Y. Tomita ◽

K. Kawakami ◽

N. Suzuki

Keyword(s):

Animal Models ◽

Cortical Spreading Depression ◽

Spreading Depression ◽

Familial Hemiplegic Migraine ◽

Hemiplegic Migraine ◽

Fos Expression

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Polycystic Kidney Disease, Autosomal Dominant Type

Atlas of Genetic Diagnosis and Counseling ◽

10.1007/978-1-60327-161-5_150 ◽

2007 ◽

pp. 797-802

Keyword(s):

Kidney Disease ◽

Polycystic Kidney Disease ◽

Autosomal Dominant ◽

Polycystic Kidney ◽

Dominant Type ◽

Autosomal Dominant Type

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The FHM1 Mutation S218L: A Severe Clinical Phenotype? A Case Report and Review of the Literature

Cephalalgia ◽

10.1111/j.1468-2982.2009.01884.x ◽

2009 ◽

Vol 29 (12) ◽

pp. 1337-1339 ◽

Cited By ~ 14

Author(s):

S Debiais ◽

C Hommet ◽

I Bonnaud ◽

MA Barthez ◽

S Rimbaux ◽

...

Keyword(s):

Autosomal Dominant ◽

Cerebral Oedema ◽

Clinical Phenotype ◽

Pregnant Patient ◽

Familial Hemiplegic Migraine ◽

Review Of The Literature ◽

Severe Phenotype ◽

Hemiplegic Migraine ◽

Motor Weakness ◽

Cacna1a Gene

Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura that is characterized by motor weakness during attacks. FHM1 is associated with mutations in the CACNA1A gene located on chromosome 19. We report a severe, prolonged HM attack in a young pregnant patient who had the S218L FHM1. This CACNA1A mutation has been associated with HM, delayed cerebral oedema and coma following minor head trauma. The case history we report suggests a specific, severe phenotype and the co-occurrence of HM and epilepsy related to the S218L FHM1 mutation.

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Lessons from Familial Hemiplegic Migraine and Cortical Spreading Depression

Neurobiological Basis of Migraine ◽

10.1002/9781118967225.ch15 ◽

2017 ◽

pp. 251-265 ◽

Cited By ~ 2

Author(s):

Daniela Pietrobon

Keyword(s):

Cortical Spreading Depression ◽

Spreading Depression ◽

Familial Hemiplegic Migraine ◽

Hemiplegic Migraine

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Limb Girdle Muscular Dystrophy, Autosomal Dominant Type 1C

Encyclopedia of Molecular Mechanisms of Disease ◽

10.1007/978-3-540-29676-8_1050 ◽

2009 ◽

pp. 1179-1180

Author(s):

Alexander K. C. Leung ◽

William Lane M. Robson ◽

Carsten Büning ◽

Johann Ockenga ◽

Janine Büttner ◽

...

Keyword(s):

Muscular Dystrophy ◽

Autosomal Dominant ◽

Limb Girdle Muscular Dystrophy ◽

Dominant Type ◽

Autosomal Dominant Type

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Punctate Calcification Group

Bone Dysplasias ◽

10.1093/med/9780190626655.003.0010 ◽

2018 ◽

pp. 351-378

Author(s):

Jürgen W. Spranger ◽

Paula W. Brill ◽

Christine Hall ◽

Gen Nishimura ◽

Andrea Superti-Furga ◽

...

Keyword(s):

Autosomal Dominant ◽

Clinical Findings ◽

Differential Diagnoses ◽

Chondrodysplasia Punctata ◽

Limb Defects ◽

Dominant Type ◽

Radiographic Features ◽

Keutel Syndrome ◽

Punctate Calcification ◽

Autosomal Dominant Type

This chapter discusses punctate calcification group and related disorders and includes discussion on Greenberg dysplasia, chondrodysplasia punctata Conradi-Hünermann type, CHILD (congenital hemidysplasia with ichthyosiform erythroderma and limb defects) syndrome, chondrodysplasia punctata (rhizomelic type), chondrodysplasia punctata (brachytelephalangic type), chondrodysplasia punctata (autosomal dominant type), chondrodysplasia punctata (tibia-metacarpal type), and Keutel syndrome. Each discussion includes major radiographic features, major clinical findings, genetics, major differential diagnoses, and a bibliography.

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