Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells

2001 ◽  
Vol 78 (3) ◽  
pp. 600-610 ◽  
Author(s):  
Su Ryeon Seo ◽  
Seon Ah Chong ◽  
Syng-Ill Lee ◽  
Jee Young Sung ◽  
Young Soo Ahn ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Pc12 Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Erk Activation ◽  
Differentiated Pc12 Cells

Carmustine induces ERK- and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species

2011 ◽  
Vol 25 (7) ◽  
pp. 1359-1365 ◽  
Author(s):  
Jeong Mi An ◽  
Seon Sook Kim ◽  
Jin Hak Rhie ◽  
Dong Min Shin ◽  
Su Ryeon Seo ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Pc12 Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Differentiated Pc12 Cells ◽  
Dependent Cell

scholarly journals Protective Effect ofScutellaria litwinowiiExtract on Serum/Glucose-Deprived Cultured PC12 Cells and Determining the Role of Reactive Oxygen Species

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Maryam Afsharzadeh ◽  
Zahra Tayarani-Najaran ◽  
Aryo Zare ◽  
Seyed Hadi Mousavi
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Pc12 Cells ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Glucose Deprivation ◽  
Serum Glucose ◽  
Oxygen Species ◽  
Species Production

Considering the wide, positive reporting of the role of reactive oxygen species in ischemic brain injury, searching for antioxidant drugs within herbal remedies is logical. In this study, the protective effects ofScutellaria litwinowiiBornm. & Sint. on cell viability and reactive oxygen species production in cultured PC12 cells were investigated under serum/glucose-deprivation-induced cell death. After cells were seeded overnight, they were then deprived of serum/glucose for 24 h. Cells were treated with different concentrations ofS. litwinowiiextract (7.75–250 μg/mL). Cell viability was quantitated by MTT assay, and intracellular reactive oxygen species production was measured by flow cytometry. Serum/glucose-deprivation induced significant cell death after 24 h (P< 0.001). Treatment withS. litwinowii(7.75–250 μg/mL) reduced serum/glucose deprivation-induced cytotoxicity in PC12 cells after 24 h. A significant increase in intracellular reactive oxygen species production was seen following serum/glucose deprivation (P< 0.001).S. litwinowii(62 and 125 μg/mL,P< 0.01) treatment reversed the increased reactive oxygen species production following ischemic insult. This demonstrates thatS. litwinowiiextract protects PC12 cells against serum/glucose-deprivation-induced cell death by antioxidant mechanisms, which indicates the potential therapeutic application ofS. litwinowiiin managing cerebral ischemic and neurodegenerative disorders.

Combretastatin A-4 and structurally related triazole analogues induce caspase-3 and reactive oxygen species-dependent cell death in PC12 cells

2013 ◽  
Vol 703 (1-3) ◽  
pp. 25-32 ◽  
Author(s):  
Gulzeb Aziz ◽  
Kristin Odlo ◽  
Trond V. Hansen ◽  
Ragnhild E. Paulsen ◽  
Gro H. Mathisen
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Pc12 Cells ◽  
Caspase 3 ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dependent Cell
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