Is there an association between long-term tamoxifen treatment and the development of carcinosarcoma (malignant mixed Müllerian tumor) of the uterus?

1995 ◽  
Vol 5 (4) ◽  
pp. 310-313 ◽  
Author(s):  
M. J. Evans ◽  
I. D. Miller ◽  
N. E.I. Langlois ◽  
H. C. Kitchener
Keyword(s):  
Tamoxifen Therapy ◽  
Tamoxifen Treatment ◽  
Uterine Carcinosarcoma ◽  
Malignant Mixed Mullerian Tumor ◽  
Malignant Mixed Müllerian Tumor ◽  
History Of ◽  
Mixed Müllerian Tumor ◽  
Mixed Mullerian Tumor ◽  
Mullerian Tumor

A cluster of five patients with endometrial carcinosarcoma (malignant mixed Müllerian tumor) occurred at our center during 1993; four of these had been prescribed long-term tamoxifen for breast carcinoma. Searching the archives for the 9-year period 1983–1992 revealed two further cases of uterine carcinosarcoma occurring in patients prescribed tamoxifen, from a total of 16 cases of this tumor. Five of the six patients diagnosed with carcinosarcoma who had been taking tamoxifen had been maintained on the drug for at least 6 years, while the other had a 3-year history of tamoxifen therapy. From these data we raise the question of an association between long-term tamoxifen treatment and development of endometrial carcinosarcoma, following the dramatic increase in the prescribing of this drug after 1984.

CD133+ Cancer Stem Cell-like Cells Derived from Uterine Carcinosarcoma (Malignant Mixed Müllerian Tumor)

Stem Cells ◽  
2011 ◽  
Vol 29 (10) ◽  
pp. 1485-1495 ◽  
Author(s):  
Batsuren Choijamts ◽  
Shiro Jimi ◽  
Toru Kondo ◽  
Yasuko Naganuma ◽  
Taichi Matsumoto ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Uterine Carcinosarcoma ◽  
Malignant Mixed Mullerian Tumor ◽  
Malignant Mixed Müllerian Tumor ◽  
Mixed Müllerian Tumor ◽  
Mixed Mullerian Tumor ◽  
Mullerian Tumor

scholarly journals A Case of Uterine Carcinosarcoma Detected Simultaneously with Breast and Colon Cancer (Triple Primary Malignant Tumor)

2018 ◽  
Vol 11 (2) ◽  
pp. 431-435 ◽  
Author(s):  
Eunhyun Lee ◽  
Yong-Il Ji
Keyword(s):  
Breast Cancer ◽  
Colon Cancer ◽  
Malignant Tumor ◽  
Uterine Carcinosarcoma ◽  
Primary Malignant Tumor ◽  
Malignant Mixed Mullerian Tumor ◽  
Malignant Mixed Müllerian Tumor ◽  
Mixed Müllerian Tumor ◽  
Mixed Mullerian Tumor ◽  
Mullerian Tumor

Uterine carcinosarcoma, also known as malignant mixed Mullerian tumor of the uterus, is rare and rarely diagnosed simultaneously with cancers in other organs. We report a case of a 63-year-old woman who was simultaneously diagnosed with uterine carcinosarcoma, breast cancer, and colon cancer.

scholarly journals Primary Peritoneal Carcinosarcoma: A Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Logan Erz ◽  
Brandon Smith ◽  
Brandon Larson ◽  
Truong Ma
Keyword(s):  
Sigmoid Colon ◽  
Female Genital Tract ◽  
Ca 125 ◽  
External Compression ◽  
Malignant Mixed Mullerian Tumor ◽  
Malignant Mixed Müllerian Tumor ◽  
History Of ◽  
Mixed Müllerian Tumor ◽  
Mixed Mullerian Tumor ◽  
Mullerian Tumor

Introduction: Carcinosarcoma, also known as malignant mixed Mullerian tumor (MMMT) is a malignant biphasic neoplasm consisting of carcinomatous and malignant non-epithelial components of mesenchymal origin. MMMTs typically arise from the female genital tract in patients over 40 years old. Primary extragenital MMMTs are extremely rare with published literature totaling 40 reported cases. The primary peritoneal carcinosarcoma is an aggressive tumor as patients with this tumor have an average survival of 7.6 months. Surgical debulking is the mainstay of treatment for these tumors and systemic chemotherapy is advised in all cases.Case: A 48-year-old Amish female presented with 5 day history of bloating and abdominal pain superimposed on a 1 year history of worsening fatigue and intermittent bloody bowel movements. She was found to have a pelvic mass on physical exam. Computed tomography scan of the abdomen and pelvis that demonstrated stricturing of the sigmoid colon, and a large multi-cystic mass in the midline pelvis measuring 12.5 × 9.9 × 11.7 cm. Colonoscopy showed stenosis due to external compression without intraluminal lesion. CEA and CA 125 levels were elevated and CA 19-9 was normal. Exploratory laparotomy was performed with en-bloc resection of a 15 cm mass originating from the sigmoid colon mesentery with several other small tumor deposits throughout the mesentery. Pathology diagnosed primary peritoneal carcinosarcoma Mullerian-type with three positive lymph nodes.Conclusion: Malignant mixed Mullerian tumor (carcinosarcoma) caries a universally grim prognosis. Herein, we report a unique case of primary peritoneal carcinosarcoma and discuss the work-up and surgical management of this rare tumor.

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