Efficacy of oral iron supplementation is not enhanced by additional intravenous iron during autologous blood donation

Transfusion ◽  
1998 ◽  
Vol 38 (8) ◽  
pp. 764-770 ◽  
Author(s):  
SM Kasper ◽  
H Lazansky ◽  
C Stark ◽  
M Klimek ◽  
R Laubinger ◽  
...  
Keyword(s):  
Iron Supplementation ◽  
Blood Donation ◽  
Autologous Blood ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Autologous Blood Donation

Maternal and fetal hemodynamic effects of autologous blood donation during pregnancy

1992 ◽  
Vol 167 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Sabine Droste ◽  
Tanya Sorensen ◽  
Thomas Price ◽  
Merlin Sayers ◽  
Thomas Benedetti ◽  
...  
Keyword(s):  
Blood Donation ◽  
Autologous Blood ◽  
Autologous Blood Donation ◽  
Hemodynamic Effects

scholarly journals Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota

2021 ◽  
Vol 12 (2) ◽  
pp. 491-502
Author(s):  
Sarah R. Bloor ◽  
Rudolph Schutte ◽  
Anthony R. Hobson
Keyword(s):  
Side Effects ◽  
Gut Microbiota ◽  
Iron Supplementation ◽  
Methanogenic Archaea ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Intestinal Lumen ◽  
Gastrointestinal Side Effects ◽  
Potential Link ◽  
The Impact

Iron deficiency anaemia (IDA) is a worldwide healthcare problem affecting approximately 25% of the global population. The most common IDA treatment is oral iron supplementation, which has been associated with gastrointestinal (GI) side effects such as constipation and bloating. These can result in treatment non-adherence and the persistence of IDA. Intravenous iron does not cause GI side effects, which may be due to the lack of exposure to the intestinal lumen. Luminal iron can cause changes to the gut microbiota, aiding the promotion of pathogenic species and decreasing beneficial protective species. Iron is vital for methanogenic archaea, which rely on iron for growth and metabolism. Increased intestinal methane has been associated with slowing of intestinal transit, constipation, and bloating. Here we explore the literature to understand a potential link between iron and methanogenesis as a novel way to understand the mechanism of oral iron supplementation induced GI side effects.

Sign in / Sign up

Export Citation Format

Share Document