scholarly journals Multicenter Epidemiological Study of Osteoporotic Fractures in Eurasia (EVA Study). A step towards reducing the burden of age-related diseases

2020 ◽  
Vol 22 ◽  
pp. 01019
Author(s):  
Alla Zakroyeva ◽  
Olga Lesnyak ◽  
Sarkis Sahakyan ◽  
Georiy Ramanau ◽  
Viktor Kazak ◽  
...  
Keyword(s):  
Preventive Intervention ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Fracture Probability ◽  
Population Based Study ◽  
Age Related ◽  
Cis Countries ◽  
Clinical Instrument ◽  
In Cis ◽  
Country Specific

To extend elderly patients’ active longevity, practitioners all over the world need a precise clinical instrument to assess the 10-year osteoporotic fractures probability and choose the optimal preventive intervention. The purpose of this research is to assess major osteoporotic (OP) fractures incidence in CIS countries and to create country-specific computing FRAX clinical prediction tools. Method. We carried out a cohort population-based study (EVA) in Russia, Belarus, Armenia, Moldova, Kazakhstan, and Uzbekistan in 2011-2018. The age- and sexspecific OP fracture incidence values were incorporated into the computing FRAX models. Results. We revealed that the highest standardized HP incidence was obtained in Kazakhstan (338 and 255 per 100 000 per year for women and men older than 50 years resp.) and Moldova (331, 0 and 155, 0 per year for women and men resp.), the lowest in Armenia (201 and 136 per 100 000 per year for women and men resp.). The FRAX models showed that in Kazakhstan, Uzbekistan, and Moldova, elderly people had the highest hip fracture probabilities. Estimates reveal that the OP fractures numbers in the EVA-project countries will grow by 1.5-3 times by 2050. Conclusion. The created national FRAX instruments should enhance the accuracy of determining fracture probability among older people, help clinicians to make decisions concerning OP prophylactic, and to step forward to reducing the burden of age-related diseases.

scholarly journals Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Alla Zakroyeva ◽  
Olga Lesnyak ◽  
Victor Cazac ◽  
Liliana Groppa ◽  
Eugen Russu ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Fracture Probability ◽  
Republic Of Moldova ◽  
National Mortality ◽  
The Republic ◽  
Specific Fracture ◽  
Country Specific ◽  
Population Based Survey

Abstract Summary Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment. Objective This paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX® tool. Methods We carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country’s population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania). Conclusion The FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment.

A Comprehensive Review of Regulatory Requirements and Registration Process of Pharmaceutical Drug Products in CIS Countries

2020 ◽  
Vol 7 (3) ◽  
pp. 162-176
Author(s):  
Kapil Pihwal ◽  
Neelam Pawar ◽  
Sheikh Aamir ◽  
Mohammad Shahbaz Alam ◽  
Vikas Rathee
Keyword(s):  
Regulatory Requirements ◽  
Health Value ◽  
Drug Products ◽  
Registration Process ◽  
Potential Market ◽  
Regulatory Guidelines ◽  
Cis Countries ◽  
In Cis ◽  
Regulatory Organization ◽  
Country Specific

Background: The CIS region has a potential market for India. The registration of the drug products in CIS regions is a challenging task because these countries have no harmonized regulatory organization. The CIS region includes 12 countries such as Russia, Kyrgyzstan, Ukraine, Uzbekistan, Kazakhstan, Tajikistan, Turkmenistan, Armenia, Azerbaijan, Belarus, Georgia and Moldova, which require different regulatory guidelines for medicinal product registration as per their FDA guidelines. The different guidelines for the same region become a challenging task for the manufacturer and exporter. The registration of the same product for different countries of CIS is not possible with the same dossier due to the lack of their regulatory harmonization. These countries obey their country-specific dossier format, so to target these market manufacturers and exporters needs to submit different dossier documents for different countries. But Ukraine and Kazakhstan have harmonization and it varies in Uzbekistan and Tajikistan. Ukraine and Kazakhstan are also imposing strict rules and expecting USFDA level documents for approval. Conclusion: The overall conclusion is that harmonization in CIS is highly imbalanced, which affects both time and cost for product registration. Harmonization is the need of the era for easy product registration, and it will be beneficial for the manufacturer, regulator, importer, exporter, and to access medicines of high public health value.

scholarly journals Age-related socio-economic and geographic disparities in breast cancer stage at diagnosis: a population-based study

2015 ◽  
Vol 25 (6) ◽  
pp. 966-972 ◽  
Author(s):  
Pegdwende O. Dialla ◽  
Patrick Arveux ◽  
Samiratou Ouedraogo ◽  
Carole Pornet ◽  
Aurélie Bertaut ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Population Based ◽  
Cancer Stage ◽  
Stage At Diagnosis ◽  
Population Based Study ◽  
Geographic Disparities ◽  
Age Related

Age Related Changes In Intensive Care Bed Utilization Over Time: A Population Based Study

2010 ◽  
Author(s):  
Kendiss Olafson ◽  
Clare D. Ramsey ◽  
Marina Yogendran ◽  
Jason Waechter ◽  
Randy Fransoo ◽  
...  
Keyword(s):  
Intensive Care ◽  
Population Based ◽  
Population Based Study ◽  
Age Related ◽  
Over Time ◽  
Age Related Changes

scholarly journals Epidemiology of hip fracture and the development of a FRAX model for Uzbekistan

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
O Lesnyak ◽  
S Ismailov ◽  
M Shakirova ◽  
N Alikhanova ◽  
A Zakroyeva ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Hip Fractures ◽  
Mortality Rates ◽  
Population Based ◽  
Fracture Probability ◽  
Medical Attention ◽  
National Mortality ◽  
The Republic ◽  
Country Specific ◽  
Population Based Survey

Abstract Summary A prospective population-based survey in a region of the Republic of Uzbekistan determined the incidence of fractures at the hip. The hip fracture rates were used to create a FRAX® model to facilitate fracture risk assessment in Uzbekistan. Objective This paper describes the epidemiology of hip fracture in the Republic of Uzbekistan that was used to develop a country-specific FRAX® tool for fracture prediction. Methods During a 1-year (2016/17) prospective population-based survey in the Pap district of the Republic of Uzbekistan, hip fractures were prospectively identified from hospital registers, trauma centres and primary care and community sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Uzbekistan. Fracture probabilities were compared with those from neighbouring Kazakhstan and Kyrgystan. Results Approximately 41% of hip fracture cases did not come to medical attention, and two thirds of patients overall were not admitted to hospital. The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 16,764 and is predicted to increase more than three-fold to 60,272 in 2050. FRAX-based probabilities were higher in Uzbekistan than Kazakhstan or Kyrgystan. Conclusion The FRAX model should enhance accuracy of determining fracture probability among the Uzbek population and help guide decisions about treatment.

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