Coronary artery disease in patients with chest pain who have low-risk clinical characteristics and negative cardiac troponin I

2001 ◽  
Vol 19 (2) ◽  
pp. 118-121 ◽  
Author(s):  
Graham S. Hillis ◽  
Craig Oliner ◽  
Brian J. O'Neil ◽  
Vinu Pansuriya ◽  
Pamela Taggart ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Chest Pain ◽  
Coronary Artery ◽  
Cardiac Troponin ◽  
Clinical Characteristics ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Low Risk ◽  
Artery Disease

Positive cardiac troponin I and T and chest pain in a patient with iatrogenic hypothyroidism and no coronary artery disease

2007 ◽  
Vol 115 (2) ◽  
pp. e83-e85 ◽  
Author(s):  
Ivo R. Buschmann ◽  
Anja Bondke ◽  
Thomas Elgeti ◽  
York Kühnle ◽  
Rainer Dietz ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Chest Pain ◽  
Coronary Artery ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Artery Disease

scholarly journals Value of Cardiac Troponin I Cutoff Concentrations below the 99th Percentile for Clinical Decision-Making

2009 ◽  
Vol 55 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Kai M Eggers ◽  
Allan S Jaffe ◽  
Lars Lind ◽  
Per Venge ◽  
Bertil Lindahl
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Risk Stratification ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Reference Population ◽  
Cardiac Troponin I ◽  
Coronary Syndrome ◽  
Artery Disease

Abstract Background: The aim of this study was to evaluate factors influencing the 99th percentile for cardiac troponin I (cTnI) when this cutoff value is established on a highly sensitive assay, and to compare the value of this cutoff to that of lower cutoffs in the prognostic assessment of patients with coronary artery disease. Methods: We used the recently refined Access AccuTnI assay (Beckman-Coulter) to assess the distribution of cTnI results in a community population of elderly individuals [PIVUS (Prospective Study of the Vasculature in Uppsala Seniors) study; n = 1005]. The utility of predefined cTnI cutoffs for risk stratification was then evaluated in 952 patients from the FRISC II (FRagmin and Fast Revascularization during InStability in Coronary artery disease) study at 6 months after these patients had suffered acute coronary syndrome. Results: Selection of assay results from a subcohort of PIVUS participants without cardiovascular disease resulted in a decrease of the 99th percentile from 0.044 μg/L to 0.028 μg/L. Men had higher rates of cTnI elevation with respect to the tested thresholds. Whereas the 99th percentile cutoff was not found to be a useful prognostic indicator for 5-year mortality, both the 90th percentile (hazard ratio 3.1; 95% CI 1.9–5.1) and the 75th percentile (hazard ratio 2.8; 95% CI 1.7–4.7) provided useful prognostic information. Sex-specific cutoffs did not improve risk prediction. Conclusions: The 99th percentile of cTnI depends highly on the characteristics of the reference population from which it is determined. This dependence on the reference population may affect the appropriateness of clinical conclusions based on this threshold. However, cTnI cutoffs below the 99th percentile seem to provide better prognostic discrimination in stabilized acute coronary syndrome patients and therefore may be preferable for risk stratification.

The clinical relevance of raised cardiac troponin I in the absence of significant angiographic coronary artery disease

2005 ◽  
Vol 100 (2) ◽  
pp. 325-330 ◽  
Author(s):  
Thuraia Nageh ◽  
Roy A. Sherwood ◽  
Ray J. Wainwright ◽  
Ajay M. Shah ◽  
Martyn R. Thomas
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Clinical Relevance ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Artery Disease

scholarly journals Cardiac troponin I release after dobutamine stress echocardiography in patients with coronary artery disease

2003 ◽  
Vol 41 (6) ◽  
pp. 426
Author(s):  
Eric Garbarz ◽  
Mathieu Poupineau ◽  
Guillaume Lefevre ◽  
David Messika-Zeitoun ◽  
Antoine Flahaut ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiac Troponin ◽  
Stress Echocardiography ◽  
Troponin I ◽  
Dobutamine Stress Echocardiography ◽  
Dobutamine Stress ◽  
Cardiac Troponin I ◽  
Artery Disease
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