In Reply to ‘Antifibrinolytic Use During Cardiac and Hepatic Surgery Makes Tubular Proteinuria–Based Early Biomarkers Poor Tools to Diagnose Perioperative Acute Kidney Injury'

2011 ◽  
Vol 57 (6) ◽  
pp. 960-961
Author(s):  
Prasad Devarajan ◽  
Catherine Krawczeski
2021 ◽  
Vol 6 (4) ◽  
pp. S82
Author(s):  
A. Bouquegneau ◽  
J. Huart ◽  
L. Lutteri ◽  
P. Erpicum ◽  
S. Grosch ◽  
...  

2020 ◽  
Vol 14 (10) ◽  
pp. 879-894
Author(s):  
Hayton Chui ◽  
Jillian Caldwell ◽  
Mariya Yordanova ◽  
Vedran Cockovski ◽  
Daniel Fredric ◽  
...  

Aim: NGAL, IL-18, KIM-1 as well as urinary TIMP2 and IGFBP7 and their mathematical product (TIMP2*IGFBP7) were evaluated for detecting pediatric aminoglycoside acute kidney injury (AG-AKI). Methods: In a prospective study, noncritically ill children received aminoglycosides (AG) ≥3 days. The area under the curve (AUC) for biomarkers to detect AKI was calculated by a) days before AKI onset; b) treatment days. Results: There were 113 AG episodes (68% febrile neutropenia). The AKI group had a higher proportion with febrile neutropenia. The AKI group had significantly lower NGAL 3 days before AKI, as patients with febrile neutropenia had a lower NGAL during AG treatment (p < 0.05). NGAL, IL-18 and TIMP2*IGFBP7 had AUC ≥0.73 at 3, 2 and 2 days before AKI onset. Conclusion: NGAL, IL-18 and TIMP2*IGFBP7 were modest early biomarkers of AG-AKI. Febrile neutropenia was associated with lower NGAL.


2015 ◽  
Vol 6 (1) ◽  
pp. 47-54
Author(s):  
Miki Sakamoto ◽  
Yuki Kobayashi ◽  
Saori Tanigawa ◽  
Hidetoshi Miyakawa ◽  
Takehito Otsubo ◽  
...  

2010 ◽  
Vol 56 (4) ◽  
pp. 632-642 ◽  
Author(s):  
Prasad Devarajan ◽  
Catherine D. Krawczeski ◽  
Mai T. Nguyen ◽  
Thelma Kathman ◽  
Zhu Wang ◽  
...  

Author(s):  
Shi‐qun Sun ◽  
Tuo Zhang ◽  
Ding Ding ◽  
Wei‐feng Zhang ◽  
Xiao‐lei Wang ◽  
...  

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