scholarly journals Tubular injury and cell-cycle arrest biomarkers to predict acute kidney injury in noncritically ill children receiving aminoglycosides

2020 ◽  
Vol 14 (10) ◽  
pp. 879-894
Author(s):  
Hayton Chui ◽  
Jillian Caldwell ◽  
Mariya Yordanova ◽  
Vedran Cockovski ◽  
Daniel Fredric ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Febrile Neutropenia ◽  
Prospective Study ◽  
Area Under The Curve ◽  
Kidney Injury ◽  
Tubular Injury ◽  
Early Biomarkers ◽  
Cycle Arrest ◽  
A Prospective Study

Aim: NGAL, IL-18, KIM-1 as well as urinary TIMP2 and IGFBP7 and their mathematical product (TIMP2*IGFBP7) were evaluated for detecting pediatric aminoglycoside acute kidney injury (AG-AKI). Methods: In a prospective study, noncritically ill children received aminoglycosides (AG) ≥3 days. The area under the curve (AUC) for biomarkers to detect AKI was calculated by a) days before AKI onset; b) treatment days. Results: There were 113 AG episodes (68% febrile neutropenia). The AKI group had a higher proportion with febrile neutropenia. The AKI group had significantly lower NGAL 3 days before AKI, as patients with febrile neutropenia had a lower NGAL during AG treatment (p < 0.05). NGAL, IL-18 and TIMP2*IGFBP7 had AUC ≥0.73 at 3, 2 and 2 days before AKI onset. Conclusion: NGAL, IL-18 and TIMP2*IGFBP7 were modest early biomarkers of AG-AKI. Febrile neutropenia was associated with lower NGAL.

scholarly journals Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury

Critical Care ◽  
2013 ◽  
Vol 17 (1) ◽  
pp. R25 ◽  
Author(s):  
Kianoush Kashani ◽  
Ali Al-Khafaji ◽  
Thomas Ardiles ◽  
Antonio Artigas ◽  
Sean M Bagshaw ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Cell Cycle Arrest ◽  
Kidney Injury ◽  
Cycle Arrest

Improving clinical prediction rules in acute kidney injury with the use of biomarkers of cell cycle arrest: a pilot study

Biomarkers ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Luke E. Hodgson ◽  
Richard M. Venn ◽  
Steve Short ◽  
Paul J. Roderick ◽  
Duncan Hargreaves ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Pilot Study ◽  
Cell Cycle Arrest ◽  
Kidney Injury ◽  
Clinical Prediction ◽  
Clinical Prediction Rules ◽  
Prediction Rules ◽  
Cycle Arrest

Evolution of diagnostic criteria for acute kidney injury in patients with decompensated cirrhosis: A prospective study in a tertiary university hospital

2020 ◽  
Vol 44 (4) ◽  
pp. 551-563
Author(s):  
Nayana Fonseca Vaz ◽  
Vanessa Nogueira Rodrigues da Cunha ◽  
Marlone Cunha-Silva ◽  
Tiago Sevá-Pereira ◽  
Jazon Romilson de Souza Almeida ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Prospective Study ◽  
Diagnostic Criteria ◽  
Kidney Injury ◽  
University Hospital ◽  
Decompensated Cirrhosis ◽  
A Prospective Study

scholarly journals Factors associated with acute kidney injury recovery in a tertiary hospital in Ghana: a prospective study

2019 ◽  
Vol 33 ◽  
Author(s):  
Perditer Okyere ◽  
Isaac Okyere ◽  
Thomas Akuetteh Ndanu ◽  
Charlotte Osafo ◽  
Bright Amankwaa
Keyword(s):  
Acute Kidney Injury ◽  
Prospective Study ◽  
Kidney Injury ◽  
Tertiary Hospital ◽  
Factors Associated ◽  
Injury Recovery ◽  
A Prospective Study

scholarly journals Vancomycin for Dialytic Therapy in Critically Ill Patients: Analysis of Its Reduction and the Factors Associated with Subtherapeutic Concentrations

2020 ◽  
Vol 17 (18) ◽  
pp. 6861
Author(s):  
Fernanda Moreira de Freitas ◽  
Welder Zamoner ◽  
Pamela Falbo dos Reis ◽  
André Luís Balbi ◽  
Daniela Ponce
Keyword(s):  
Acute Kidney Injury ◽  
Serum Concentration ◽  
Protective Factor ◽  
Bacterial Resistance ◽  
Inhibitory Concentration ◽  
Area Under The Curve ◽  
Kidney Injury ◽  
Factors Associated ◽  
Intermittent Haemodialysis ◽  
A Prospective Study

This study aimed to evaluate the reduction in vancomycin through intermittent haemodialysis (IHD) and prolonged haemodialysis (PHD) in acute kidney injury (AKI) patients with sepsis and to identify the variables associated with subtherapeutic concentrations. A prospective study was performed in patients admitted at an intensive care unit (ICU) of a Brazilian hospital. Blood samples were collected at the start of dialytic therapy, after 2 and 4 h of treatment and at the end of therapy to determine the serum concentration of vancomycin and thus perform pharmacokinetic evaluation and PK/PD modelling. Twenty-seven patients treated with IHD, 17 treated with PHD for 6 h and 11 treated with PHD for 10 h were included. The reduction in serum concentrations of vancomycin after 2 h of therapy was 26.65 ± 12.64% and at the end of dialysis was 45.78 ± 12.79%, higher in the 10-h PHD group, 57.70% (40, 48–64, 30%) (p = 0.037). The ratio of the area under the curve to minimal inhibitory concentration (AUC/MIC) at 24 h in the PHD group was significantly smaller than at 10 h (p = 0.047). In the logistic regression, PHD was a risk factor for an AUC/MIC ratio less than 400 (OR = 11.59, p = 0.033), while a higher serum concentration of vancomycin at T0 was a protective factor (OR = 0.791, p = 0.009). In conclusion, subtherapeutic concentrations of vancomycin in acute kidney injury (AKI) patients in dialysis were elevated and may be related to a higher risk of bacterial resistance and mortality, besides pointing out the necessity of additional doses of vancomycin during dialytic therapy, mainly in PHD.

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