139 A Case Report and Literature Review of SGLT2 Inhibitor-Associated Euglycemic Diabetic Ketoacidosis after Bariatric Surgery

2021 ◽  
Vol 77 (4) ◽  
pp. 610-611
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Erasmia Sampani ◽  
Pantelis Sarafidis ◽  
Chrysostomos Dimitriadis ◽  
Efstratios Kasimatis ◽  
Dimitra Daikidou ◽  
...  

2020 ◽  
Vol 2 (2) ◽  
pp. 218-221 ◽  
Author(s):  
Katherine M. Wang ◽  
Robert T. Isom

2020 ◽  
pp. 1-2
Author(s):  
Ajay Budhwar ◽  
Parul Malhotra

We describe a case report of a patient who presented with euglycemic diabetic ketoacidosis (euDKA), six days after starting treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitor, Canagliflozin. ‘Euglycemic diabetic ketoacidosis’ or ‘DKA with lower-than-anticipated glucose levels’ (as recommended by AACE/ACE) is a rare, challenging and easy to miss the diagnosis A 41-year-old male with a history of type 2 Diabetes Mellitus presented with uncontrolled hyperglycemia. Canagliflozin (SGLT2 inhibitor) was added to his anti-diabetic regimen of Metformin and Sitagliptin. Six days later, he presented with symptoms of diabetic ketoacidosis with normal blood glucose of 131mg/dl. The patient was further investigated with arterial blood gas analysis and serum ketone studies, keeping in view of the potential of euglycemic diabetic ketoacidosis (euDKA) with SGLT2 inhibitor use. The clinical picture and lab values of the patient were consistent with diabetic ketoacidosis(DKA), although it is rare in type 2 DM. Blood glucose was in the normal range which could have delayed the diagnosis if the physician was not vigilant. If one had only focused on the blood glucose, then this potentially fatal condition could have been missed. However, when other causes of anion gap metabolic acidosis were excluded and the lab values of urine ketones, elevated beta-hydroxybutyrate, reduced bicarbonate, and normal lactate interpreted, it leads to the diagnosis of SGLT2 inhibitor-associated euglycemic DKA. We performed a literature review of this topic and discuss the history of euglycemic diabetic ketoacidosis, risk factors, pathophysiology, diagnosis, management, and prevention of SGLT2 inhibitor-induced euDKA.


Author(s):  
sameena wazir ◽  
Saheed Shittu ◽  
Khaled Dukhan ◽  
Maram Sharief ◽  
Stephen Beer ◽  
...  

Euglycemic DKA (EKDA) is a variant of DKA. In this case report, we discuss the course of COVID-19 infection in a pregnant woman with gestational diabetes who developed severe euglycemic diabetic ketoacidosis triggered by various precipitating factors, including starvation, caused by Covid-19 infection and its gastrointestinal effects.


Author(s):  
Daniel Valente Batista ◽  
Carla Antoniana Ferreira de Almeida Vieira ◽  
Thomaz Alexandre Costa ◽  
Eduardo Gomes Lima

2021 ◽  
Vol 27 (6) ◽  
pp. S25-S26
Author(s):  
Joi C. Hester ◽  
Stacy Zimmerman ◽  
Teresa Nimmo ◽  
Wesley Cunningham ◽  
Joshua Liu ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document