Linaclotide Significantly Improved Bowel Habits and Relieved Abdominal Symptoms in Adults with Chronic Constipation: Data from a Large 4-Week, Randomized, Double-Blind, Placebo-Controlled Study

Anthony J. Lembo; Jeffrey M. Johnston; James E. MacDougall; Bernard J. Lavins; Donald A. Fitch; Brenda I. Jeglinski; Caroline B. Kurtz; Douglas A. Drossman; Mark G. Currie

doi:10.1053/j.gastro.2008.05.062

Linaclotide Significantly Improved Bowel Habits and Relieved Abdominal Symptoms in Adults with Chronic Constipation: Data from a Large 4-Week, Randomized, Double-Blind, Placebo-Controlled Study

Gastroenterology ◽

10.1053/j.gastro.2008.05.062 ◽

2008 ◽

Vol 135 (1) ◽

pp. 295 ◽

Cited By ~ 4

Author(s):

Anthony J. Lembo ◽

Jeffrey M. Johnston ◽

James E. MacDougall ◽

Bernard J. Lavins ◽

Donald A. Fitch ◽

...

Keyword(s):

Chronic Constipation ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Bowel Habits ◽

Abdominal Symptoms

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A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation

Neurogastroenterology & Motility ◽

10.1111/j.1365-2982.2010.01533.x ◽

2010 ◽

Vol 22 (9) ◽

pp. 991-e255 ◽

Cited By ~ 73

Author(s):

S. Müller-lissner ◽

A. Rykx ◽

R. Kerstens ◽

L. Vandeplassche

Keyword(s):

Elderly Patients ◽

Chronic Constipation ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo

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Probiotics Ameliorate Stool Consistency in Patients with Chronic Constipation: A Randomized, Double-Blind, Placebo-Controlled Study

Digestive Diseases and Sciences ◽

10.1007/s10620-018-5139-8 ◽

2018 ◽

Vol 63 (10) ◽

pp. 2754-2764 ◽

Cited By ~ 11

Author(s):

Jin Young Yoon ◽

Jae Myung Cha ◽

Ju Kyoung Oh ◽

Pei Lei Tan ◽

Sae Hun Kim ◽

...

Keyword(s):

Chronic Constipation ◽

Stool Consistency ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo

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Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - a 12-week, randomized, double-blind, placebo-controlled study

Alimentary Pharmacology & Therapeutics ◽

10.1111/j.1365-2036.2008.03884.x ◽

2009 ◽

Vol 29 (3) ◽

pp. 315-328 ◽

Cited By ~ 203

Author(s):

E. M. M. QUIGLEY ◽

L. VANDEPLASSCHE ◽

R. KERSTENS ◽

J. AUSMA

Keyword(s):

Quality Of Life ◽

Clinical Trial ◽

Chronic Constipation ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Severe Chronic Constipation

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Prucalopride in the treatment of chronic constipation in patients from the Asia‐Pacific region: a randomized, double‐blind, placebo‐controlled study

Neurogastroenterology & Motility ◽

10.1111/j.1365-2982.2012.01983.x ◽

2012 ◽

Vol 24 (11) ◽

pp. 999 ◽

Cited By ~ 62

Author(s):

M. Ke ◽

D. Zou ◽

Y. Yuan ◽

Y. Li ◽

L. Lin ◽

...

Keyword(s):

Chronic Constipation ◽

Asia Pacific ◽

Controlled Study ◽

Pacific Region ◽

Asia Pacific Region ◽

Double Blind ◽

Double Blind Placebo

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Tu1627 - Linaclotide is Effective and Safe for Patients with Chronic Constipation in Japan: A Phase III Randomized, Double-Blind, Placebo-Controlled Study with a Long-Term Open-Label Extension Study

Gastroenterology ◽

10.1016/s0016-5085(18)33271-2 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-973-S-974

Author(s):

Shin Fukudo ◽

Hiroto Miwa ◽

Atsushi Nakajima ◽

Yoshikazu Kinoshita ◽

Masanori Kosako ◽

...

Keyword(s):

Chronic Constipation ◽

Phase Iii ◽

Extension Study ◽

Controlled Study ◽

Open Label ◽

Double Blind ◽

Double Blind Placebo ◽

Open Label Extension

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Determining a Clinical Optimal Dose of Elobixibat, A Novel IBAT Inhibitor, in Japanese Patients with Chronic Constipation: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

Gastroenterology ◽

10.1016/s0016-5085(17)30523-1 ◽

2017 ◽

Vol 152 (5) ◽

pp. S48-S49 ◽

Cited By ~ 1

Author(s):

Atsushi Nakajima ◽

Mitsunori Seki

Keyword(s):

Chronic Constipation ◽

Optimal Dose ◽

Japanese Patients ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo

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Polyethylene glycol 3350 plus electrolytes for chronic constipation: a 2-week, randomized, double-blind, placebo-controlled study with a 52-week open-label extension

Journal of Gastroenterology ◽

10.1007/s00535-019-01581-x ◽

2019 ◽

Vol 54 (9) ◽

pp. 792-803 ◽

Cited By ~ 6

Author(s):

Atsushi Nakajima ◽

Kazuhiko Shinbo ◽

Akira Oota ◽

Yoshikazu Kinoshita

Keyword(s):

Polyethylene Glycol ◽

Chronic Constipation ◽

Controlled Study ◽

Open Label ◽

Double Blind ◽

Double Blind Placebo ◽

Open Label Extension

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A3309, an Ileal Bile Acid Transport (IBAT /ASBT) Inhibitor, Significantly Improved Stool Frequency and Other Constipation-Related Complaints in Adults With Chronic Constipation: Data From an 8-Week, Randomized, Double-Blind, Placebo-Controlled Study

Gastroenterology ◽

10.1016/s0016-5085(11)60010-3 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-3 ◽

Cited By ~ 3

Author(s):

William D. Chey ◽

Michael Camilleri ◽

Lin Chang ◽

Leif Rikner ◽

Hans Graffner

Keyword(s):

Bile Acid ◽

Chronic Constipation ◽

Stool Frequency ◽

Controlled Study ◽

Acid Transport ◽

Double Blind ◽

Double Blind Placebo ◽

Bile Acid Transport

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High‐dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double‐blind, placebo‐controlled study with a long‐term open‐label extension study in Japan

Neurogastroenterology & Motility ◽

10.1111/nmo.13487 ◽

2018 ◽

Vol 31 (1) ◽

pp. e13487 ◽

Cited By ~ 4

Author(s):

Shin Fukudo ◽

Hiroto Miwa ◽

Atsushi Nakajima ◽

Yoshikazu Kinoshita ◽

Masanori Kosako ◽

...

Keyword(s):

Chronic Constipation ◽

Phase Iii ◽

Extension Study ◽

Controlled Study ◽

High Dose ◽

Open Label ◽

Double Blind ◽

Double Blind Placebo ◽

Open Label Extension

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Mo1540 THE EFFICACY AND SAFETY OF GCWB104 (FLOS LONICERA EXTRACT) IN FUNCTIONAL DYSPEPSIA: A SINGLE-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

Gastroenterology ◽

10.1016/s0016-5085(20)32906-1 ◽

2020 ◽

Vol 158 (6) ◽

pp. S-887-S-888

Author(s):

Nayoung Kim ◽

Yonghoon Choi ◽

Dong Ho Lee

Keyword(s):

Functional Dyspepsia ◽

Controlled Study ◽

Efficacy And Safety ◽

Single Center ◽

Double Blind ◽

Double Blind Placebo

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