Exam 1: Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies

2013 ◽  
Vol 145 (5) ◽  
pp. e13-e14
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Diseases ◽  
Meta Analysis ◽  
Population Based ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Over Time

Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies

2013 ◽  
Vol 145 (5) ◽  
pp. 996-1006 ◽  
Author(s):  
Alexandra D. Frolkis ◽  
Jonathan Dykeman ◽  
María E. Negrón ◽  
Jennifer deBruyn ◽  
Nathalie Jette ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Diseases ◽  
Meta Analysis ◽  
Population Based ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Over Time

Postoperative Mortality Among Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis of Population-Based Studies

2015 ◽  
Vol 149 (4) ◽  
pp. 928-937 ◽  
Author(s):  
Sunny Singh ◽  
Ahmed Al-Darmaki ◽  
Alexandra D. Frolkis ◽  
Cynthia H. Seow ◽  
Yvette Leung ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Diseases ◽  
Meta Analysis ◽  
Postoperative Mortality ◽  
Population Based ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Sa1102 Post-Operative Mortality for the Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Population-Based Studies

2014 ◽  
Vol 146 (5) ◽  
pp. S-200 ◽  
Author(s):  
Sundeep Singh ◽  
Ahmed Al-Darmaki ◽  
Alexandra D. Frolkis ◽  
Cynthia H. Seow ◽  
Yvette Leung ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Diseases ◽  
Operative Mortality ◽  
Meta Analysis ◽  
Population Based ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Systematic review and meta-analysis of the incidence and prevalence and 30-year trend of inflammatory bowel diseases in Asia: a study protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e031854 ◽  
Author(s):  
Ali Reza Safarpour ◽  
Manoosh Mehrabi ◽  
Abbasali Keshtkar ◽  
Fardad Edjtehadi ◽  
Kamran Bagheri Lankarani
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Diseases ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Population Based ◽  
Combination Method ◽  
Effect Model ◽  
Statistical Heterogeneity ◽  
Bowel Diseases ◽  
Inflammatory Bowel

IntroductionInflammatory bowel diseases, including ulcerative colitis (UC), Crohn’s disease (CD) and inflammatory bowel disease type unclassified (IBDU), are debilitating conditions that are rapidly growing in developing countries. Given the absence of a comprehensive systematic review and meta-analysis containing a rigorous pooled estimate of incidence and prevalence of UC, CD and IBDU, this study was conducted to determine the incidence and prevalence of these conditions in Asia and their 30-year trend.Methods and analysisBased on predefined criteria, electronic databases, including PubMed/MEDLINE, Scopus, WoS (Clarivate Analytics), Embase and Google Scholar, and some databases pertaining to Asian countries will be searched for population-based cross-sectional studies and the baseline data and final reports of population-based cohort studies involving paediatric and adult patients, with no language restrictions, from 1 January 1988 to 30 December 2018. Any disagreement in the stages of screening, selecting, quality assessment and data extraction between the two independent reviewers will be resolved by consensus, and if the disagreement is not resolved, a third expert opinion will be sought. The combination method will be used based on methodological similarities in the included studies by the Fixed Effect Model or the Random Effect Model. Forest plots will be plotted for all the studies to show the separated and pooled incidence and prevalence and their corresponding 95% CIs. The Q-statistic test and I2 statistic will be used to assess statistical heterogeneity. Funnel plots will be used to assess potential reporting bias and nonsignificant study effect. Begg’s and Egger’s tests will also be performed, and significant results (p>0.1) shall suggest a publication bias, in which case the ‘trim and fill’ method will be used. The time trends for UC, CD and IBDU will be calculated using a cumulative meta-analysis.Ethics and disseminationSince this review will use previously published studies, it will not require the consent of an Ethics Committee. The results will be prepared and disseminated through a peer-reviewed journal and will be presented in relevant conferences.PROSPERO registration numberCRD42019131477.

scholarly journals Progression of Elderly Onset Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Population-Based Cohort Studies

2020 ◽  
Vol 18 (11) ◽  
pp. 2437-2447.e6 ◽  
Author(s):  
Jacob J. Rozich ◽  
Parambir S. Dulai ◽  
Mathurin Fumery ◽  
William J. Sandborn ◽  
Siddharth Singh
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Inflammatory Bowel Diseases ◽  
Meta Analysis ◽  
Population Based ◽  
Bowel Diseases ◽  
Elderly Onset ◽  
Inflammatory Bowel

scholarly journals P295 VALIDation of the IBD-Disk instrument for assessing disability in inflammatory bowel diseases in a population-based cohort: The VALIDate study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S299-S301
Author(s):  
C Le Berre ◽  
A Bourreille ◽  
M Flamant ◽  
G Bouguen ◽  
L Siproudhis ◽  
...  
Keyword(s):  
Internal Consistency ◽  
Inflammatory Bowel Diseases ◽  
Population Based ◽  
Large Cohort ◽  
Inactive Disease ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Physician Patient ◽  
Over Time

Abstract Background Inflammatory bowel diseases (IBD) are disabling disorders. The IBD-Disability Index (IBD-DI) was developed for quantifying disability in IBD patients but is difficult to use. The IBD-Disk is a shortened and visual adaptation of the IBD-DI. It has not been validated yet. The main objectives were to validate the IBD-Disk in a large cohort of IBD patients and to assess its variability over time. Methods From March 2018 to July 2019, IBD patients from three university-affiliated hospitals responded twice to both IBD-Disk and IBD-DI at 3–12 months intervals (NCT03590639). Validation included concurrent validity, reproducibility, internal consistency, and evaluation of IBD-Disk correlation with IBD activity. Variability was assessed by comparing scores between baseline and follow-up visits. Results A total of 559 patients (73% Crohn’s disease, 27% ulcerative colitis) were included and 389 were followed up (Table 1). There was a good correlation between IBD-Disk and IBD-DI scores (r = 0.75, p < 0.001) (Figure 1). The IBD-Disk was significantly higher in patients with active disease according to Physician/Patient Global Assessment (Figure 2), clinical scores (Figure 3), and biomarkers levels, compared with patients with inactive disease. Reproducibility was excellent (intra-class correlation coefficient = 0.90), as well as internal consistency (Cronbach’s α = 0.89). The IBD-Disk score significantly decreased in patients becoming inactive over time. Conclusion This is the first study to validate the IBD-Disk in a large cohort of IBD patients, demonstrating that it is a valid and reliable tool for quantifying disability in clinical practice. Further studies are warranted to assess its correlation with endoscopic activity, to explore its responsiveness to change, and to evaluate the factors associated with disability.

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