MUC5AC serves as the nexus for β-catenin/c-Myc interplay to promote glutamine dependency during pancreatic cancer chemoresistance

Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as dense stroma microenvironment, abnormal signaling pathways, and genetic heterogeneity of the tumors contribute to its chemoresistant characteristics. Amongst these features, growth factors have been observed to play crucial roles in cancer cell survival, progression, and chemoresistance. Here we review the role of the individual growth factors in pancreatic cancer chemoresistance. Importantly, the interplay between the tumor microenvironment and chemoresistance is explored in the context of pivotal role played by growth factors. We further describe current and future potential therapeutic targeting of these factors.

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Tumor-associated macrophage-secreted 14-3-3ζ signals via AXL to promote pancreatic cancer chemoresistance

Oncogene ◽

10.1038/s41388-019-0803-9 ◽

2019 ◽

Vol 38 (27) ◽

pp. 5469-5485 ◽

Cited By ~ 13

Author(s):

Gabriele D’Errico ◽

Marta Alonso-Nocelo ◽

Mireia Vallespinos ◽

Patrick C. Hermann ◽

Sonia Alcalá ◽

...

Keyword(s):

Pancreatic Cancer ◽

Tumor Associated Macrophage ◽

Cancer Chemoresistance

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Effect of Hypercapnia, an Element of Obstructive Respiratory Disorder, on Pancreatic Cancer Chemoresistance and Progression

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2019.12.033 ◽

2020 ◽

Vol 230 (4) ◽

pp. 659-667

Author(s):

Avinoam Nevler ◽

Samantha Z. Brown ◽

David Nauheim ◽

Carla Portocarrero ◽

Ulrich Rodeck ◽

...

Keyword(s):

Pancreatic Cancer ◽

Respiratory Disorder ◽

Cancer Chemoresistance

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SRPX2 boosts pancreatic cancer chemoresistance by activating PI3K/AKT axis

Open Medicine ◽

10.1515/med-2020-0157 ◽

2020 ◽

Vol 15 (1) ◽

pp. 1072-1082

Author(s):

Zhenyuan Gao ◽

Jisong Wu ◽

Xiao Wu ◽

Jialei Zheng ◽

Yimei Ou

Keyword(s):

Pancreatic Cancer ◽

Cell Lines ◽

Progressive Disease ◽

High Serum ◽

Ductal Epithelial Cell ◽

Chemotherapeutic Response ◽

Epithelial Cell Lines ◽

Before And After ◽

Cancer Chemoresistance ◽

The Impact

AbstractBackground and aimThis investigation was aimed at disclosing whether SRPX2 affected pancreatic cancer (PC) chemoresistance by regulating PI3K/Akt/mTOR signaling.MethodsTotally 243 PC patients were recruited, and they were incorporated into partial remission (PR) group, stable disease (SD) group and progressive disease (PD) group in accordance with their chemotherapeutic response. PC cell lines (i.e. AsPC1, Capan2, VFPAC-1, HPAC, PANC-1, BxPC-3 and SW1990) and human pancreatic ductal epithelial cell lines (hTERT-HPNE) were also collected.ResultsPC patients of SD + PD group were associated with higher post-chemotherapeutic SRPX2 level than PR group, and their post-chemotherapeutic SRPX2 level was above the pretherapeutic SRPX2 level (P < 0.05). PR population showed lower SRPX2 level after chemotherapy than before chemotherapy (P < 0.05). Besides high serum SRPX2 level and SRPX2 level change before and after chemotherapy were independent predictors of poor PC prognosis. Additionally, si-SRPX2 enhanced chemosensitivity of PC cell lines, and expressions of p-PI3K, p-AKT and p-mTOR were suppressed by si-SRPX2 (P < 0.05). IGF-1 treatment could changeover the impact of si-SRPX2 on proliferation, migration, invasion and chemoresistance of PC cells (P < 0.05).ConclusionThe SRPX2-PI3K/AKT/mTOR axis could play a role in modifying progression and chemoresistance of PC cells, which might help to improve PC prognosis.

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