scholarly journals Functional testing for tranexamic acid effect duration using modified viscoelastometry

2020 ◽  
Vol 34 ◽  
pp. S41-S42
Author(s):  
T. Kammerer ◽  
P. Groene ◽  
S. Sappel ◽  
P. Scheiermann ◽  
S. Schäfer
Keyword(s):  
Tranexamic Acid ◽  
Functional Testing ◽  
Acid Effect ◽  
Effect Duration

Clinical study of Evaluation of the Effect of Tranexamic Acid in Primary Cleft Palate Surgery in Children

2021 ◽  
Vol 15 (10) ◽  
pp. 2708-2710
Author(s):  
Mufassar Nishat ◽  
Sohail Iqbal ◽  
Armaghan Ahmed ◽  
Shoaib Younas ◽  
Liaqat Ali Deokah ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Cleft Palate ◽  
Acid Group ◽  
Control Group ◽  
Double Blind Study ◽  
Double Blind ◽  
Surgical Incision ◽  
Acid Effect ◽  
Quality Of Surgery ◽  
Surgical Field

Aim : To evaluate tranexamic acid effect on quality of surgery. Design: Double-blind study, Prospective and randomized Place & time of study: June 2020 to may 2021Allama iqbal memorial trust hospital Gujranwala. Methods: Two groups of candidates were made. The saline was administered to the control group whereas tranexamic acid was administered as 0.01g/kg in a bolus form, before surgical incision to tranexamic acid group. On a 10-point scale, grading of surgical field, primary hemorrhage and satisfaction of surgeon Results: As far as operating surgeon satisfaction is concerned, noteworthy improvement was witnessed and evaluation of surgery in case of control individuals group as compared to in case of test individual group in the tranexamic acid individuals group was estimated against the control members of group. Conclusion: tranexamic acid was given in dosage of 0.01g/kg of before surgical incision showed improved in a great way in surgical field during repairing of cleft palate operation. Keywords: tranexamic acid surgical field, pediatric, palatoplasty satisfaction, cleft palate

Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery

2020 ◽  
Author(s):  
Philipp Groene ◽  
Sophia R. Sappel ◽  
Thomas Saller ◽  
Tobias Nitschke ◽  
Paula A. Sa ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Orthopaedic Surgery ◽  
Functional Testing

scholarly journals Quantification of Tranexamic Acid Reversal of Fibrinolysis Using Thromboelastography and Low Dose Tranexamic Acid Effect in Open Heart Surgery

1998 ◽  
Vol 34 (6) ◽  
pp. 1193
Author(s):  
Sung Hong Lee ◽  
Kyung Tae Kim ◽  
Hwan Duck Kim ◽  
Sung Ju Kim ◽  
Cheol Hwoy Hur ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Low Dose ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Acid Effect

Comparison of Tranexamic-Acid and Aprotinin regarding the outcome after cardiac surgery

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
A Cetinkaya ◽  
A Van Linden ◽  
Z Szalay ◽  
A Afflerbach ◽  
J Blumenstein ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Tranexamic Acid

Plasminogen-Plasmin System IX. Specific Binding of Tranexamic Acid to Plasmin

1975 ◽  
Vol 33 (03) ◽  
pp. 573-585 ◽  
Author(s):  
Masahiro Iwamoto
Keyword(s):  
Tranexamic Acid ◽  
Affinity Chromatography ◽  
Dissociation Constant ◽  
Factor Xiii ◽  
Specific Binding ◽  
The Other ◽  
Inhibitory Mechanism ◽  
Binding Studies ◽  
Similar Affinity ◽  
Fibrin Structure

SummaryInteractions between tranexamic acid and protein were studied in respect of the antifibrinolytic actions of tranexamic acid. Tranexamic acid did neither show any interaction with fibrinogen or fibrin, nor was incorporated into cross-linked fibrin structure by the action of factor XIII. On the other hand, tranexamic acid bound to human plasmin with a dissociation constant of 3.5 × 10−5 M, which was very close to the inhibition constant (3.6 × 10−5 M) for this compound in inhibiting plasmin-induced fibrinolysis. The binding site of tranexamic acid on plasmin was not the catalytic site of plasmin, because TLCK-blocked plasmin also showed a similar affinity to tranexamic acid (the dissociation constant, 2.9–4.8 × 10−5 M).In the binding studies with the highly purified plasminogen and TLCK-plasmin preparations which were obtained by affinity chromatography on lysine-substituted Sepharose, the molar binding ratio was shown to be 1.5–1.6 moles tranexamic acid per one mole protein.On the basis of these and other findings, a model for the inhibitory mechanism of tranexamic acid is presented.

Evaluation of the Fibrin Plate Method for Estimating Plasminogen Activators

1972 ◽  
Vol 28 (01) ◽  
pp. 075-088 ◽  
Author(s):  
N. A Marsh ◽  
C. L Arocha-Pinango
Keyword(s):  
Tranexamic Acid ◽  
Plasminogen Activators ◽  
Heated Plate ◽  
Plasminogen Activation ◽  
Response Curves ◽  
Plate Method ◽  
Single Plate ◽  
Effect Of Additives ◽  
Threefold Increase ◽  
Fibrin Plate

SummaryA study was carried out in order to evaluate the Astrup and Mullertz fibrin plate method for estimating plasminogen activators.Choice of a suitable fibrinogen substrate was found to be the most important factor in setting up a workable assay. Many preparations contained a large proportion of non-clottable protein and plates made from these fibrinogens were usually unreliable. In addition, plasminogen content varied appreciably between preparations so that sensitivity of the method required careful calibration with each new batch of fibrinogen.The effect of additives in the fibrin plate was considered and it was found that calcium chloride alone was sufficient to ensure a stabilised plate which could be stored at 4° C for some time. The addition of tranexamic acid (AMCHA) was found to be a slightly more convenient way of estimating direct proteolytic activity, compared with the traditional heated plate. However neither method distinguished completely between proteolysis and plasminogen activation.In order to improve the precision of the method, the use of an analysis of variance technique has been studied. This technique provides information on the dose-response curves of test and unknown substances, and in addition produces an approximately threefold increase in precision over single plate tests.

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