Effects of a long-acting formulation of octreotide on renal function and renal sodium handling in cirrhotic patients with portal hypertension: A randomized, double-blind, controlled trial

1. It has been suggested that endogenous renal prostaglandin E (PGE) constitutes a determinant of renal haemodynamics and renal sodium handling in patients with cirrhosis. We have accordingly assessed the effects of augmenting endogenous prostaglandins on renal function. We utilized water immersion to the neck since previous studies demonstrated that the redistribution of blood volume and concomitant central hypervolaemia thus induced produces a prompt and marked augmentation of PGE excretion in normal man. 2. Thirteen cirrhotic patients were studied twice while in balance on a daily 10 mmol of sodium/100 mmol of potassium diet during control and during water immersion. Urinary PGE was determined hourly for 6 h. 3. Cirrhotic patients manifested a wide continuum of responses characterized by either a sluggish or barely discernible natriuretic response (n = 5) or an appropriate natriuretic response (n = 8). 4. Water immersion to the neck resulted in a highly significant increase in mean UPGEV, which was threefold that manifested by normal subjects studied under identical conditions. Furthermore, cumulative sodium excretion during immersion correlated with PGE excretion (P < 0·05). 5. These findings, together with the results of studies utilizing prostaglandin synthase inhibitors, are consistent with the postulate that renal PGE may play a role in the alterations of renal function in decompensated cirrhosis.

Download Full-text

A Randomized Double Blind Placebo Controlled Trial about the Effect of Probiotics on Cognitive Findings of Children with Portal Hypertension

Journal of Clinical and Experimental Hepatology ◽

10.1016/j.jceh.2017.01.074 ◽

2017 ◽

Vol 7 ◽

pp. S56-S57

Author(s):

Valeria Casotti ◽

Lorenzo D’Antiga ◽

Lorella Caffi ◽

Stefano Quadri ◽

Mara Colusso ◽

...

Keyword(s):

Portal Hypertension ◽

Controlled Trial ◽

Double Blind ◽

Double Blind Placebo

Download Full-text

Comparison of the Effect of Lidocaine versus a Lidocaine-Bupivacaine Combination in a Periprostatic Nerve Block Undergoing Transrectal Ultrasound-Guided Prostate Biopsy: A Double-Blind Randomized Controlled Trial

Current Urology ◽

10.1159/000447132 ◽

2015 ◽

Vol 9 (3) ◽

pp. 153-158 ◽

Cited By ~ 1

Author(s):

Ali H. Yilmaz ◽

Elif Ziypak ◽

Tevfik Ziypak ◽

Mehmet Aksoy ◽

Senol Adanur ◽

...

Keyword(s):

Nerve Block ◽

Local Anesthetic ◽

Pain Control ◽

Controlled Trial ◽

Late Phase ◽

Patient Comfort ◽

Double Blind ◽

Vas Scores ◽

Long Acting ◽

Periprostatic Nerve Block

Introduction: To determine whether a combination of the long acting local anesthetic, bupivacaine, and lidocaine is better than lidocaine alone in the long-term pain control, which is a short-acting anesthetic. Materials and Methods: In group 1, periprostatic nerve block was applied to both neurovascular areas with 2% lidocaine (5 ml) in an isotonic solution (5 ml). In group 2, the combination of 2% lidocaine (5 ml) and 5mg/ml bupivacaine (5 ml) was used for the PPNB. Results: In the first 30 minutes the mean VAS scores of groups 1 and 2 were 2.1 ± 0.2 and 1.2 ± 0.1, respectively (p = 0.002). VAS scores of group II determined at 1, 2, 4, 6, and 8 hours after the biopsy were significantly lower since it was (p < 0.05). Conclusion: While periprostatic nerve block for late phase pain control, applying a combination of a long-acting local anesthetic, such as bupivacaine, is effective in terms of pain control and patient comfort.

Download Full-text