Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells
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AbstractIn this study, three semisynthetic betulonic acid-based compounds, 20(29)-dihydrolup-2-en[2,3-d]isoxazol-28-oic acid, 1-betulonoylpyrrolidine, and lupa-2,20(29)-dieno[2,3-b]pyrazin-28-oic acid, were studied in biotransformation experiments using Nicotiana tabacum and Catharanthus roseus cell suspension cultures. Biotransformation was performed using cyclodextrin to aid dissolving poorly water-soluble substrates. Several new derivatives were found, consisting of oxidized and glycosylated (pentose- and hexose-conjugated) products.
1995 ◽
Vol 95
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pp. 569-574
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1992 ◽
Vol 9
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pp. 32-33
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1980 ◽
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1981 ◽
pp. 129-133
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2012 ◽
Vol 112
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pp. 43-54
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2011 ◽
Vol 107
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pp. 91-100
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