Transition-Metal-Catalyzed Alkylation of Polyfluoroarenes through C–F Bond Cleavage

The polyfluoroarenes are a subgroup of organofluorines that are widely utilized in both medicinal chemistry and materials science. We briefly summarize recent advances in the synthesis of these important compounds, with particular attention to our recent CuH-catalyzed defluorinative alkylation of polyfluoroarenes with alkenes in a highly site-selective C–F bond-cleavage fashion.1 Introduction2 Transition-Metal-Catalyzed Alkylation through Selective C–F Bond Cleavage3 CuH-Catalyzed Defluorinative Alkylation of Polyfluoroarenes with Alkenes4 Summary and Outlook