Diastereoselective synthesis of spiropyrazolones via 1,3-dipolar [3+2] cycloadditions between pyrazolone-based olefins and N, N’-cyclic azomethine imines

Synlett ◽  
2021 ◽  
Author(s):  
Hong-Wu Zhao ◽  
Zhe Tang ◽  
Hui-Hui Wu ◽  
Xiao-Zu Fan ◽  
Heng Zhang ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Reaction Mechanism ◽  
Single Crystal ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Diastereoselective Synthesis ◽  
X Ray ◽  
Stereochemical Configuration ◽  
Azomethine Imines ◽  
Single Crystal Structure Analysis

Under the catalysis of PhCO2H, the 1,3-dipolar [3+2] cycloaddition between pyrazolone-based olefins and N, N’-cyclic azomethine imines proceeded readily, thus delivering structurally novel spiropyrazolones with up to 98% yield and >20:1 dr. The relative stereochemical configuration of the obtained spiropyrazolones was unambiguously assigned by X-ray single crystal structure analysis. The diastereoselective formation of the title spiropyrazolones was interpreted by the hypothesized reaction mechanism.

1,3-Dipolar [3+3] Cycloaddition of 1,4-Benzodiazepinone-Based Nitrones with α-Halohydroxamates for Diastereoselective Synthesis of Novel d-Edge Heterocycle-Fused 1,4-Benzodiazepinones

Synlett ◽  
2021 ◽  
Author(s):  
Hong-Wu Zhao ◽  
Heng Zhang ◽  
Lu-Yu Cai ◽  
Zhe Tang ◽  
Xiao-Zu Fan ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Reaction Mechanism ◽  
Single Crystal ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Diastereoselective Synthesis ◽  
Reaction Conditions ◽  
Relative Configuration ◽  
X Ray ◽  
Single Crystal Structure Analysis

Promoted by K2CO3 (2.0 equiv), the 1,3-dipolar [3+3] cycloaddition between 1, 4-benzodiazepinone-based nitrones and α-halohydroxamates processed smoothly under the mild reaction conditions and delivered structurally novel and complex cis or trans-configured d-edge-heterocycle-fused 1,4-benzodiazepinones in up to >99% isolated yield with >20:1 dr. The relative configuration of the title chemical entities was clearly identified with the use of X-ray single crystal structure analysis. The reaction mechanism was assumed to interpret the diastereoselective production of the obtained cis or trans-configured d-edge-heterocycle-fused 1, 4-benzodiazepinones.

Stereoselective Syntheses of Alkyl Z-2-(2-amino-4-oxo-1,3-selenazol- 5(4H)-ylidene)acetates in Solvent-Free Conditions, X-Ray Single Crystal Structure Analysis of Ethyl Z-2-(2-amino-4-oxo-1,3-selenazol- 5(4H)-ylidene)acetate

2005 ◽  
Vol 60 (5) ◽  
pp. 569-571 ◽  
Author(s):  
Ali Ramazani ◽  
Ali Morsali ◽  
Bijan Ganjeie ◽  
Ali Reza Kazemizadeh ◽  
Ebrahim Ahmadi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Single Crystal ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Solvent Free ◽  
Single Crystal Structure ◽  
X Ray ◽  
Solvent Free Conditions ◽  
Stereoselective Syntheses ◽  
Single Crystal Structure Analysis

Selenourea reacts with dialkyl acetylenedicarboxylates under solvent-free conditions to form 1:1 adducts, which undergo a cyclization reaction to produce alkyl Z-2-(2-amino-4-oxo-1,3-selenazol- 5(4H)-ylidene)acetates, in good yields. The stereochemistry of the ethyl Z-2-(2-amino-4-oxo-1,3- selenazol-5(4H)-ylidene)acetate was established by X-ray single crystal structure analysis. The reaction is completely stereoselective.

X-ray and neutron diffraction investigation at 298 K of NH4I · NH3 and ND4I · ND3 containing the cation H3N – H … NH3+ and D3N – D … ND3+

1992 ◽  
Vol 200 (3-4) ◽  
Author(s):  
H. J. Berthold ◽  
E. Vonholdt ◽  
R. Wartchow ◽  
T. Vogt
Keyword(s):  
Crystal Structure ◽  
Low Temperature ◽  
Neutron Diffraction ◽  
Single Crystal ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Single Crystal Structure ◽  
X Ray ◽  
Single Crystal Structure Analysis

AbstractNHA single crystal structure analysis of NThe deuterated compound NThe structures of the ordered low temperature phases will be reported separately.

Stereoselective Synthesis of Multifunctionalized Nitrones via Conjugate Addition Between α-Halogeno Hydrazones and Nitroso Compounds

Synlett ◽  
2021 ◽  
Author(s):  
Hong-Wu Zhao ◽  
Xiao-Fan Bi ◽  
Hai-Liang Pang ◽  
Zhe Tang ◽  
Heng Zhang ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Single Crystal ◽  
Structure Analysis ◽  
Chemical Structure ◽  
Stereoselective Synthesis ◽  
Conjugate Addition ◽  
Crystal Structure Analysis ◽  
Nitroso Compounds ◽  
X Ray ◽  
Single Crystal Structure Analysis

In the presence of Na2CO3, the conjugate addition between α-halogeno hydrazones and nitroso compounds proceeded readily, thus delivering multifunctionalized nitrones in the reasonable chemical yields with excellent strereoselectivities. The chemical structure and stereochemical configuration of title chemical entities were unambiguously identified by an X-ray single crystal structure analysis.

Intrastrand bis(guanine) chelation of trinucleoside diphosphate d(CpGpG) to cis-platinum: an x-ray single-crystal structure analysis

1987 ◽  
Vol 109 (2) ◽  
pp. 592-594 ◽  
Author(s):  
Gert Admiraal ◽  
Johannis L. Van der Veer ◽  
Rudolf A. G. De Graaff ◽  
Jeroen H. J. Den Hartog ◽  
Jan Reedijk
Keyword(s):  
Crystal Structure ◽  
Single Crystal ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Single Crystal Structure ◽  
X Ray ◽  
Single Crystal Structure Analysis
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