Hypothermic circulatory arrest and retrograde cerebral perfusion for aortic arch surgery after dissection: learning from the past, defining the future

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
A Karayiannis ◽  
T Kiask ◽  
G Gotzamanis ◽  
BM Kemkes
2016 ◽  
Vol 20 (4) ◽  
pp. 58
Author(s):  
A. V. Mikhailov ◽  
D. Zh. Ziyatdinov

<p><strong>Aim.</strong> Emphasis in the study was placed on the analysis of the immediate results of interventions on the aortic arch in patients operated under antegrade/retrograde cerebral perfusion and mild hypothermic circulatory arrest.<br /><strong>Methods.</strong> Data on 49 patients who underwent intervention on the aortic arch with antegrade (24 patients – group 1) or retrograde (25 patients – group 2) cerebral perfusion and moderate hypothermic circulatory arrest over a period from 2011 to 2015 was collected and analyzed retrospectively. 26.5 % (13) of patients were treated for acute type I aortic dissection. Bicuspid aortic valve was present in 33 % (16), Marfan syndrome was in 4 % (2), aortic regurgitation grade II and III accounted for 56 % (27).<br /><strong>Results.</strong> The mean age of patients was 58±11 and 58±12 years (р=0.9), males amounted to 83 % and 76 % (р=0.524), NYHA functional class was 2.9±0.5 and 2.8±0.8 (р=0.689) in group 1 and group 2, respectively. Cardiopulmonary bypass time amounted to 190±44 and 207±50 min (р=0.227), aortic cross-clamp time ran to 119±32 and 113±26 min (р=0.503), circulatory arrest lasted 21±12 and 21±15 min (р=0.968) in group 1 and group 2, respectively. Postoperative mortality, prolonged ICU time, complications, stroke were 0 and 8 % (р=0.157), 71 and 48 % (р=0.182), 67 and 64 % (р=0.831), 12.5 and 12 % (р=0.955) in group 1 and group 2, respectively. <br /><strong>Conclusion</strong>. Antegrade and retrograde cerebral perfusion under a short mild hypothermic circulatory arrest during aortic arch surgery showed comparable immediate results. Antegrade cerebral perfusion should be used in most cases as more physiological.</p><p>Received 7 September 2016. Accepted 14 November 2016.</p><p><strong>Funding:</strong> The study had no sponsorship.<br /><strong>Conflict of interest:</strong> The authors declare no conflict of interest.<br /><strong>Author contributions</strong><br />All authors meet ICMJE authorship criteria and contributed equally at all stages of the research.</p>


2019 ◽  
Vol 1 (3) ◽  
pp. 99-104
Author(s):  
Mohamed Abdel Fouly

Background: Antegrade cerebral perfusion (ACP) minimizes deep hypothermic circulatory arrest (DHCA) duration during arch surgery in infants, which may impact the outcomes of the repair. We aimed to evaluate the effect of adding antegrade cerebral perfusion to deep hypothermic circulatory arrest on DHCA duration and operative outcomes of different aortic arch operations in infants. Methods: We retrospectively collected data from infants (<20 weeks old) who underwent aortic arch reconstruction (Norwood operation, arch reconstruction for the hypoplastic arch and interrupted aortic arch) using DHCA alone (n=88) or combined with ACP (n=26). We excluded patients who had concomitant procedures and those with preoperative neurological disability. Results: There was no difference between groups as regards the age, gender, and the operation performed (p= 0.64; 0.87 and 0.50; respectively). Among the 114 patients, 11 (9.6%) had operative mortality, and 14 (12.3%) had cerebral infarction diagnosed with CT scanning. Adding ACP to DHCA significantly reduced DHCA duration from 50.7 ± 10.6 minutes to 22.4 ± 6.2 minutes (p<0.001) and lowered the mortality (11 vs. 0; p=0.066) and cerebral infarction (13 vs. 1; p=0.18). No statistically significant difference between the two groups in terms of ischemic time (p=0.63) or hospital stay duration (p=0.47). Conclusion: Using ACP appears to reduce the DHCA duration and was associated with better survival and neurological outcomes of aortic arch surgery in infants. A study with longer follow-up to evaluate the long-term neurological sequelae is recommended.


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