<p><strong>Aim.</strong> Emphasis in the study was placed on the analysis of the immediate results of interventions on the aortic arch in patients operated under antegrade/retrograde cerebral perfusion and mild hypothermic circulatory arrest.<br /><strong>Methods.</strong> Data on 49 patients who underwent intervention on the aortic arch with antegrade (24 patients – group 1) or retrograde (25 patients – group 2) cerebral perfusion and moderate hypothermic circulatory arrest over a period from 2011 to 2015 was collected and analyzed retrospectively. 26.5 % (13) of patients were treated for acute type I aortic dissection. Bicuspid aortic valve was present in 33 % (16), Marfan syndrome was in 4 % (2), aortic regurgitation grade II and III accounted for 56 % (27).<br /><strong>Results.</strong> The mean age of patients was 58±11 and 58±12 years (р=0.9), males amounted to 83 % and 76 % (р=0.524), NYHA functional class was 2.9±0.5 and 2.8±0.8 (р=0.689) in group 1 and group 2, respectively. Cardiopulmonary bypass time amounted to 190±44 and 207±50 min (р=0.227), aortic cross-clamp time ran to 119±32 and 113±26 min (р=0.503), circulatory arrest lasted 21±12 and 21±15 min (р=0.968) in group 1 and group 2, respectively. Postoperative mortality, prolonged ICU time, complications, stroke were 0 and 8 % (р=0.157), 71 and 48 % (р=0.182), 67 and 64 % (р=0.831), 12.5 and 12 % (р=0.955) in group 1 and group 2, respectively. <br /><strong>Conclusion</strong>. Antegrade and retrograde cerebral perfusion under a short mild hypothermic circulatory arrest during aortic arch surgery showed comparable immediate results. Antegrade cerebral perfusion should be used in most cases as more physiological.</p><p>Received 7 September 2016. Accepted 14 November 2016.</p><p><strong>Funding:</strong> The study had no sponsorship.<br /><strong>Conflict of interest:</strong> The authors declare no conflict of interest.<br /><strong>Author contributions</strong><br />All authors meet ICMJE authorship criteria and contributed equally at all stages of the research.</p>