Influence of Polyethylene Glycol (PEG) Extraction on the C-Peptide Determination in Sera from Insulin-Dependent Diabetic Patients with Circulating Insulin Antibodies*)

2009 ◽  
Vol 95 (01) ◽  
pp. 119-122 ◽  
Author(s):  
W. Besch ◽  
H. Keilacker ◽  
K.-D. Kohnert ◽  
M. Ziegler
Keyword(s):  
Polyethylene Glycol ◽  
Insulin Antibodies ◽  
Diabetic Patients ◽  
C Peptide ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Diagnosis of self-induced hyperinsulinism in an insulin-dependent diabetic patient by radioimmunoassay of free C-peptide.

1981 ◽  
Vol 27 (1) ◽  
pp. 184-186 ◽  
Author(s):  
M T Meistas ◽  
M S Kumar ◽  
O P Schumacher
Keyword(s):  
Polyethylene Glycol ◽  
Diabetic Patient ◽  
Insulin Antibodies ◽  
Self Administration ◽  
C Peptide ◽  
Free Insulin ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Antigen Antibody ◽  
Plasma Free Insulin

Abstract On the basis of results of simultaneous determinations of plasma free insulin and free c-peptide, episodes of hypoglycemia in an insulin-dependent diabetic were attributed to surreptitious self-administration of insulin. Immunoreactive c-peptide values were falsely increased and diagnostically misleading when measured in unextracted plasma. After preliminary removal of antigen/antibody complexes from the plasma by extraction with polyethylene glycol, the c-peptide values, referred to as "free c-peptide," were suppressed. We suggest that insulin antibodies formed complexes with proinsulin-like material in the plasma of this patient, which accounted for most of the c-peptide immunoreactivity in her unextracted plasma. These complexes must be removed if c-peptide measurements are to be accurate.

Effect of Insulin Antibodies on Insulin Pharmacokinetics and Glucose Utilization in Insulin-dependent Diabetic Patients

Diabetes ◽  
1985 ◽  
Vol 34 (2) ◽  
pp. 166-173 ◽  
Author(s):  
W. K. Waldhausl ◽  
P. Bratusch-Marrain ◽  
V. Kruse ◽  
I. Jensen ◽  
P. Nowotny ◽  
...  
Keyword(s):  
Glucose Utilization ◽  
Insulin Antibodies ◽  
Diabetic Patients ◽  
Insulin Pharmacokinetics ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Effect of insulin antibodies on insulin pharmacokinetics and glucose utilization in insulin-dependent diabetic patients

Diabetes ◽  
1985 ◽  
Vol 34 (2) ◽  
pp. 166-173 ◽  
Author(s):  
W. K. Waldhausl ◽  
P. Bratusch-Marrain ◽  
V. Kruse ◽  
I. Jensen ◽  
P. Nowotny ◽  
...  
Keyword(s):  
Glucose Utilization ◽  
Insulin Antibodies ◽  
Diabetic Patients ◽  
Insulin Pharmacokinetics ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Renal metabolism of C peptide in type I (insulin-dependent) diabetic patients

1991 ◽  
Vol 5 (2-3) ◽  
pp. 110-111
Author(s):  
I. Zavaroni ◽  
C. Robaudo ◽  
S. Mazza ◽  
L. Gnudi ◽  
S. Saffioti ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Type I ◽  
Renal Metabolism ◽  
C Peptide ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals Disappearance rate of insulin antibodies after discontinuing insulin treatment in 42 Type 2 (non-insulin-dependent) diabetic patients

Diabetologia ◽  
1984 ◽  
Vol 27 (6) ◽  
pp. 592-595 ◽  
Author(s):  
C. Ionescu-T�rgovi�te ◽  
I. Mincu ◽  
L. Simionescu ◽  
D. Cheta ◽  
Z. Mirodon ◽  
...  
Keyword(s):  
Insulin Treatment ◽  
Insulin Antibodies ◽  
Diabetic Patients ◽  
Disappearance Rate ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic
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