Efficacy and safety of ferric carboxymaltose in correcting iron-deficiency anemia: a review of randomized controlled trials across different indications

Introduction: This systematic review and meta-analysis aims to explore the influence of ferumoxytol versus placebo on iron deficiency anemia. Methods: We search for randomized controlled trials (RCTs) assessing the effect of ferumoxytol on iron deficiency anemia on PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases. This meta-analysis is performed using the random-effects model. Results: Four RCTs are included in the meta-analysis. Compared with the control group for iron deficiency anemia, intravenous ferumoxytol can significantly improve the proportion of patients with a ≥20 g/L hemoglobin (Hb) increase (RR = 18.43; 95% CI = 7.29–46.57; p < 0.00001), the proportion of patients with an Hb level ≥120 g/L (RR = 18.55; 95% CI = 8.66–39.72; p < 0.00001), transferrin saturation (mean difference = 11.08; 95% CI = 9.86–12.31; p < 0.00001) and FACIT-fatigue score (mean difference = 4.60; 95% CI = 3.21–6.00; p < 0.00001), but has no remarkable influence on adverse events (RR = 1.33; 95% CI = 0.84–2.10; p = 0.22), serious adverse events (RR = 1.22; 95% CI = 0.74–2.02; p = 0.44), and death (RR = 0.32; 95% CI = 0.05–1.95; p = 0.22). Conclusions: Intravenous ferumoxytol can provide the important benefits for iron deficiency anemia.

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Iron deficiency anemia in Helicobacter pylori infection: meta-analysis of randomized controlled trials

Scandinavian Journal of Gastroenterology ◽

10.3109/00365521003663670 ◽

2010 ◽

Vol 45 (6) ◽

pp. 665-676 ◽

Cited By ~ 76

Author(s):

Yuan Wenzhen ◽

Li Yumin ◽

Yang Kehu ◽

Ma Bin ◽

Guan Quanlin ◽

...

Keyword(s):

Helicobacter Pylori ◽

Iron Deficiency ◽

Randomized Controlled Trials ◽

Iron Deficiency Anemia ◽

Meta Analysis ◽

Helicobacter Pylori Infection ◽

Deficiency Anemia ◽

Controlled Trials ◽

Randomized Controlled

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Comparison of Efficacy and Safety of Intravenous Ferric Carboxymaltose vs Iron Sucrose in the Treatment of Antepartum Iron Deficiency Anemia: A Randomized Controlled Trial

Journal of SAFOG with DVD ◽

10.5005/jp-journals-10006-1441 ◽

2016 ◽

Vol 8 (4) ◽

pp. 314-318

Author(s):

Mrityunjay C Metgud ◽

Satwik B Metgud ◽

Mrutyunjaya B Bellad ◽

Shridevi H Metgud

Keyword(s):

Randomized Controlled Trial ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Controlled Trial ◽

Iron Sucrose ◽

Deficiency Anemia ◽

Ferric Carboxymaltose ◽

Efficacy And Safety ◽

Randomized Controlled

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EFFICACY AND SAFETY OF FERRIC CARBOXYMALTOSE IN THE MANAGEMENT OF IRON-DEFICIENCY ANEMIA IN PATIENTS WITH GASTROINTESTINAL AND LIVER DISEASE.

10.26226/morressier.57c53841d462b80296c9c7fe ◽

2016 ◽

Author(s):

Marco Mendolaro

Keyword(s):

Liver Disease ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Deficiency Anemia ◽

Ferric Carboxymaltose ◽

Efficacy And Safety

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A study for efficacy and safety of ferric carboxymaltose versus iron sucrose in iron deficiency anemia among pregnant women in tertiary care hospital

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20192418 ◽

2019 ◽

Vol 8 (6) ◽

pp. 2280

Author(s):

Divyani Agrawal ◽

Deepa Lokwani Masand

Keyword(s):

Iron Deficiency ◽

Adverse Events ◽

Pregnant Women ◽

Iron Deficiency Anemia ◽

Intravenous Iron ◽

Iron Sucrose ◽

Deficiency Anemia ◽

Ferric Carboxymaltose ◽

Efficacy And Safety ◽

Anemia During Pregnancy

Background: Anemia is one of the common manageable problem among the pregnant women worldwide, which contributes to maternal and perinatal mortality. This study aims to compare the efficacy and safety of intravenous ferric carboxymaltose with intravenous iron sucrose in treating anemia during pregnancy. Objective of this study was to compare safety and efficacy of intravenous ferric carboxymaltose with intravenous ferric sucrose in iron deficiency anemia during pregnancy.Methods: It’s an interventional prospective study conducted in Department of Obstetrics and Gynecology at NIMS, Jaipur, Rajasthan, India constituting of 100 pregnant women. Group 1- 50 pregnant women were treated with intravenous ferric carboxymaltose and Group 2: 50 pregnant women were treated with intravenous iron sucrose. Hemoglobin and serum ferritin levels were measured pre and post treatment with parenteral iron therapy. The efficacy of intravenous ferric carboxymaltose in comparison to intravenous iron sucrose was assessed. The evaluation of safety and tolerance with the parenteral therapy was also performed.Results: Anemia during pregnancy was more prevalent among the reproductive age group and in multiparous women. The mean rise in the hemoglobin level with ferric carboxymaltose was 2.92 gm/dl and with that of iron, sucrose was 1.08 gm/dl. The man rise in the serum ferritin levels with ferric carboxymaltose was 64.97ng/ml and with iron sucrose was 31.64 ng/ml. Ferric carboxymaltose was observed to be safer with no adverse events in comparison to the Iron sucrose which was related with adverse events among 03 pregnant women.Conclusions: Intravenous ferric carboxymaltose was more efficacious and safer in comparison to intravenous iron sucrose among pregnant women. Hence, ferric carboxymaltose is the drug of choice in treatment of iron deficiency anemia during pregnancy.

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