A recently developed potassium-chloride and n-acetylhistidine enriched storage solution is superior to isotonic sodium-chloride-solution for intraoperative short-time storage of saphenous vein grafts

Objective: It was aimed to evaluate the effect of intravenous (IV) granisetron used for nausea and vomiting prophylaxis on hypotension and bradycardia caused by spinal anesthesia. Methods: 120 ASA 1-2 patients undergoing elective surgery under spinal anesthesia were randomly divided into Group G (Ganisetron; n=60) and Group P (Placebo; n=60) groups. Five minutes before spinal anesthesia, Group G received 1 mg intravenous granisetron diluted in 10 mL of isotonic sodium chloride solution and Group P received 10 mL of isotonic sodium chloride solution. Spinal anesthesia with hyperbaric bupivacaine 0.5%, 15 mg at the level of L4-5 was applied for both groups. Hemodynamic data, sensory and motor block parameters were recorded before and after spinal anaesthesia every 5 minutes during 20 minutes of surgery. Results: There was no difference in the demographic data of both groups. Although hemodynamic data showed a decrease in both groups according to initial values, blood pressure measurements in group G were significantly higher than the first measure values. There was no significant difference in heart rate values between the groups. Conclusion: Intravenous granisetron reduces hypotension after spinal anesthesia, but it has no significant effect on heart rate.

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Swelling of polyacrylamide-based hydrogel in aqueous solutions of low-molecular salts

Doklady of the National Academy of Sciences of Belarus ◽

10.29235/1561-8323-2020-64-3-293-299 ◽

2020 ◽

Vol 64 (3) ◽

pp. 293-299

Author(s):

E. V. Vorobieva

Keyword(s):

Sodium Chloride ◽

Potassium Chloride ◽

Chloride Solution ◽

Sodium Chloride Solution ◽

External Solution ◽

Swelling Kinetics ◽

Polymer Gel ◽

Molecular Salts ◽

Gel Phase ◽

Kinetics Of

The swelling kinetics of cross-linked polyacrylamide was studied depending on the composition of the external solution. It was shown that the polymer gel swelling during the transition from water to a potassium or sodium chloride solution and vice versa sharply decreases, then gradually increases. The swelling of gel in a solution of sodium chloride is higher than that of potassium chloride. In the equilibrium swollen gel, the concentration of salts in the gel phase is higher than in the external solution and increases with the transition from potassium chloride to sodium chloride.

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Endotracheal Suctioning With or Without Instillation of Isotonic Sodium Chloride Solution in Critically Ill Children

American Journal of Critical Care ◽

10.4037/ajcc2003.12.3.212 ◽

2003 ◽

Vol 12 (3) ◽

pp. 212-219 ◽

Cited By ~ 33

Author(s):

Debra A. Ridling ◽

Lynn D. Martin ◽

Susan L. Bratton

Keyword(s):

Sodium Chloride ◽

Oxygen Saturation ◽

Endotracheal Tube ◽

Critically Ill ◽

Nosocomial Pneumonia ◽

Chloride Solution ◽

Sodium Chloride Solution ◽

Critically Ill Children ◽

Endotracheal Tubes ◽

Isotonic Sodium Chloride

• Background Instillation of isotonic sodium chloride solution for endotracheal tube suctioning is controversial. Research has focused on the effect of such instillation in adults; no studies in children have been published.• Objectives (1) To describe differences in oxygen saturation depending on whether or not isotonic sodium chloride solution is instilled during suctioning and (2) to describe the rates of occlusion of endotracheal tubes and nosocomial pneumonia.• Methods A convenience sample of 24 critically ill patients were enrolled before having suctioning and after informed consent had been given. Ages ranged from 10 weeks to 14 years. Patients were randomized to 1 of 2 groups. In group 1, subjects received between 0.5 and 2.0 mL of isotonic sodium chloride solution, depending on their age, once per suctioning episode. In group 2, subjects received no such solution. A total of 104 suctioning episodes were analyzed. Oxygen saturation was recorded at predetermined intervals before and for 10 minutes after suctioning. Occlusion of endotracheal tubes and rates of nosocomial pneumonia also were compared.• Results Patients who had isotonic sodium chloride solution instilled experienced significantly greater oxygen desaturation 1 and 2 minutes after suctioning than did patients who did not. No occlusions of endotracheal tubes and no cases of nosocomial pneumonia occurred in either group.• Conclusions Results of this study support a growing body of evidence that instillation of isotonic sodium chloride solution during endotracheal tube suctioning may not be beneficial and actually may be harmful.

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