Selective Endothelin-B Receptor Stimulation Increases Vascular Endothelial Growth Factor in the Rat Brain during Postnatal Development

Drug Research ◽  
2015 ◽  
Vol 65 (11) ◽  
pp. 607-613 ◽  
Author(s):  
M. Leonard ◽  
P. Prazad ◽  
B. Puppala ◽  
A. Gulati
2010 ◽  
Vol 50 (6) ◽  
pp. 449-455 ◽  
Author(s):  
Atsushi KATSUMATA ◽  
Kenji SUGIU ◽  
Koji TOKUNAGA ◽  
Noboru KUSAKA ◽  
Kyoichi WATANABE ◽  
...  

1998 ◽  
Vol 18 (8) ◽  
pp. 887-895 ◽  
Author(s):  
Takeshi Hayashi ◽  
Koji Abe ◽  
Yasuto Itoyama

Vascular endothelial growth factor (VEGF) is a secreted polypeptide and plays a pivotal role in angiogenesis in vivo. However, it also increases vascular permeability, and might exacerbate ischemic brain edema. The effect of this factor on the brain after transient ischemia was investigated in terms of infarct volume and edema formation, as well as cellular injury. After 90 minutes of transient middle cerebral artery occlusion, VEGF (1.0 ng/μL, 9 μL) was topically applied on the surface of the reperfused rat brain. A significant reduction of infarct volume was found in animals with VEGF application ( P < 0.001) at 24 hours of reperfusion as compared with cases with vehicle treatment. Brain edema was significantly reduced in VEGF-treated animals ( P = 0.01), and furthermore, extravasation of Evans blue was also decreased in those animals ( P < 0.01). Terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick end labeling and immunohistochemical analysis for 70-kDa heat shock protein showed an amelioration of the stainings at 24 and 48 hours after reperfusion with VEGF treatment, which indicated reduction of neuronal damage. These results indicate that treatment with topical VEGF application significantly reduces ischemic brain damage, such as infarct volume, edema formation, and extravasation of Evans blue, and that the reductions were associated with that of neuronal injury.


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