New Alkyl Phloroglucinol Derivatives from Rhus trichocarpa Roots and Their Cytotoxic Effects on Human Gastric Adenocarcinoma AGS Cells

Planta Medica ◽  
2016 ◽  
Vol 82 (07) ◽  
pp. 645-649 ◽  
Author(s):  
Ki Lee ◽  
Ji Choi ◽  
Hyeon Kim ◽  
Xi-Tao Yan ◽  
Hyeji Shin ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Ags Cells ◽  
Cytotoxic Effects ◽  
Phloroglucinol Derivatives ◽  
Human Gastric Adenocarcinoma

Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3

2007 ◽  
Vol 257 (1) ◽  
pp. 56-64 ◽  
Author(s):  
Cheng-Yun Jin ◽  
Cheol Park ◽  
JaeHun Cheong ◽  
Byung Tae Choi ◽  
Tae Ho Lee ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Caspase 3 ◽  
Ags Cells ◽  
Human Gastric Adenocarcinoma

scholarly journals Isolation of β-Indomycinone Guided by Cytotoxicity Tests from Streptomyces sp. IFM11607 and Revision of its Double Bond Geometry

2014 ◽  
Vol 9 (9) ◽  
pp. 1934578X1400900
Author(s):  
Kentaro Tsukahara ◽  
Kazufumi Toume ◽  
Hanako Ito ◽  
Naoki Ishikawa ◽  
Masami Ishibashi
Keyword(s):  
Double Bond ◽  
Gastric Adenocarcinoma ◽  
Coupling Constant ◽  
Ags Cells ◽  
Streptomyces Sp ◽  
Human Gastric Adenocarcinoma

The antibiotic β-indomycinone was isolated from Streptomyces sp. IFM11607 by cytotoxicity-guided fractionation against human gastric adenocarcinoma AGS cells, and the geometry of its Δ17,18-double bond was revised from E to Z based on the coupling constant.

scholarly journals Euphorbiae Immifusae Sensitizes Apoptosis of TRAIL-resistant Human Gastric Adenocarcinoma AGS Cells

2008 ◽  
Vol 18 (1) ◽  
pp. 120-128 ◽  
Author(s):  
Jae-Jun Lee ◽  
Dong-Hyuk Shin ◽  
Sang-Eun Park ◽  
Won-Il Kim ◽  
Dong-Il Park ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Ags Cells ◽  
Human Gastric Adenocarcinoma

scholarly journals The Effect of Sodium Nitrite on Induction of Apoptosis in Human Gastric Adenocarcinoma Epithelia (AGS) Cells

2015 ◽  
Vol 06 (11) ◽  
pp. 496-501 ◽  
Author(s):  
Yanchao Liu ◽  
Qiliang Qin ◽  
Agula Bo ◽  
Hairong Zhang ◽  
Qing Zhang ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Sodium Nitrite ◽  
Ags Cells ◽  
Human Gastric Adenocarcinoma ◽  
Induction Of Apoptosis

scholarly journals Cellular responses to chlorin-based photosensitizer DH-II-24 under darkness in human gastric adenocarcinoma AGS cells

2011 ◽  
Vol 102 (3) ◽  
pp. 549-556 ◽  
Author(s):  
Young-Cheol Lim ◽  
Je-Ok Yoo ◽  
Seong-Sik Kang ◽  
Young-Myeong Kim ◽  
Kwon-Soo Ha
Keyword(s):  
Gastric Adenocarcinoma ◽  
Cellular Responses ◽  
Ags Cells ◽  
Human Gastric Adenocarcinoma

scholarly journals Germacranolides from Enhydra fluctuans with TRAIL-resistance Abrogating Activity

2017 ◽  
Vol 12 (8) ◽  
pp. 1934578X1701200
Author(s):  
Firoj Ahmed ◽  
Utpal K. Karmakar ◽  
Midori A. Arai ◽  
Naoki Ishikawa ◽  
Samir K. Sadhu ◽  
...  
Keyword(s):  
Natural Products ◽  
Cancer Cells ◽  
Gastric Adenocarcinoma ◽  
Screening Program ◽  
Antitumor Agent ◽  
Ags Cells ◽  
Normal Cells ◽  
Aerial Parts ◽  
Human Gastric Adenocarcinoma ◽  
Trail Resistance

TRAIL selectively kills cancer cells without harming most normal cells. However, TRAIL resistance is a major problem for its therapeutic use. Developing a strategy to overcome resistance is crucial for the successful use of TRAIL as an antitumor agent. In our screening program of natural products that can abrogate TRAIL resistance, four germacranolides (1–4) were isolated from the aerial parts of Enhydra fluctuans. All compounds exhibited potent TRAIL-resistance overcoming activity against TRAIL-resistant human gastric adenocarcinoma (AGS) cells.

scholarly journals Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma

2021 ◽  
Vol 14 (3) ◽  
pp. 208
Author(s):  
Margarida Espadinha ◽  
Valentina Barcherini ◽  
Lídia M. Gonçalves ◽  
Elies Molins ◽  
Alexandra M. M. Antunes ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Anticancer Agents ◽  
Liver Microsomes ◽  
New Drugs ◽  
Ags Cells ◽  
Polycyclic Compounds ◽  
Enantiomerically Pure ◽  
Human Gastric Adenocarcinoma ◽  
Ags Cell Line ◽  
High Level

Gastric cancer is one of the deadliest cancers in modern societies, so there is a high level of interest in discovering new drugs for this malignancy. Previously, we demonstrated the ability of tryptophanol-derived polycyclic compounds to activate the tumor suppressor protein p53, a relevant therapeutic target in cancer. In this work, we developed a novel series of enantiomerically pure tryptophanol-derived small molecules to target human gastric adenocarcinoma (AGS) cells. From an initial screening of fourteen compounds in AGS cell line, a hit compound was selected for optimization, leading to two derivatives selective for AGS gastric cells over other types of cancer cells (MDA-MB-231, A-549, DU-145, and MG-63). More importantly, the compounds were non-toxic in normal cells (HEK 293T). Additionally, we show that the growth inhibition of AGS cells induced by these compounds is mediated by apoptosis. Stability studies in human plasma and human liver microsomes indicate that the compounds are stable, and that the major metabolic transformations of these molecules are mono- and di-hydroxylation of the indole ring.

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