scholarly journals Iliac Crest Bone Graft versus Local Autograft or Allograft for Lumbar Spinal Fusion: A Systematic Review

2016 ◽  
Vol 6 (6) ◽  
pp. 592-606 ◽  
Author(s):  
Alexander Tuchman ◽  
Darrel S. Brodke ◽  
Jim A. Youssef ◽  
Hans-Jörg Meisel ◽  
Joseph R. Dettori ◽  
...  
2021 ◽  
Vol 50 (6) ◽  
pp. E11
Author(s):  
Ryan R. Diaz ◽  
Amey R. Savardekar ◽  
Jared R. Brougham ◽  
Danielle Terrell ◽  
Anthony Sin

OBJECTIVE The use of allograft cellular bone matrices (ACBMs) in spinal fusion has expanded rapidly over the last decade. Despite little objective data on its effectiveness, ACBM use has replaced the use of traditional autograft techniques, namely iliac crest bone graft (ICBG), in many centers. METHODS In accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a systematic review was conducted of the PubMed, Cochrane Library, Scopus, and Web of Science databases of English-language articles over the time period from January 2001 to December 2020 to objectively assess the effectiveness of ACBMs, with an emphasis on the level of industry involvement in the current body of literature. RESULTS Limited animal studies (n = 5) demonstrate the efficacy of ACBMs in spinal fusion, with either equivalent or increased rates of fusion compared to autograft. Clinical human studies utilizing ACBMs as bone graft expanders or bone graft substitutes (n = 5 for the cervical spine and n = 8 for the lumbar spine) demonstrate the safety of ACBMs in spinal fusion, but fail to provide conclusive level I, II, or III evidence for its efficacy. Additionally, human studies are plagued with several limiting factors, such as small sample size, lack of prospective design, lack of randomization, absence of standardized assessment of fusion, and presence of industry support/relevant conflict of interest. CONCLUSIONS There exist very few objective, unbiased human clinical studies demonstrating ACBM effectiveness or superiority in spinal fusion. Impartial, well-designed prospective studies are needed to offer evidence-based best practices to patients in this domain.


10.14444/8023 ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 179-185
Author(s):  
Kaustubh Ahuja ◽  
Paras Aggarwal ◽  
Jatin Raj Sareen ◽  
Sidharath Mohindru ◽  
Pankaj Kandwal

Author(s):  
Dylan Luxenburg ◽  
Kevin J. Bondar ◽  
Lara L. Cohen ◽  
David Constantinescu ◽  
Spencer Barnhill ◽  
...  

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