scholarly journals Facial Nerve Schwannomas Mimicking as Vestibular Schwannomas

2017 ◽  
Vol 78 (04) ◽  
pp. 283-287
Author(s):  
Sean Wise ◽  
David Cohen ◽  
Jason Bell ◽  
Dennis Bojrab ◽  
Michael LaRouere ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Outcome Measures ◽  
Action Potentials ◽  
Internal Auditory Canal ◽  
Vestibular Schwannomas ◽  
Tumor Capsule ◽  
Spontaneous Action ◽  
The Mean ◽  
Spontaneous Action Potentials ◽  
Stimulation Of

Objective The objective of this study was to identify preoperative and intraoperative findings that may aid in distinguishing facial nerve schwannomas (FNS) from vestibular schwannomas (VSs), particularly in cases limited to the internal auditory canal (IAC) and cerebellopontine angle (CPA). Study Design This was a retrospective study. Setting This study was set at a Tertiary Referral Center. Patients Seventeen cases from October 2002 to July 2015 with an IAC/CPA mass presumed to be a VS who were found to have a FNS intraoperatively. Main Outcome Measures The main outcome measures included preoperative presentation, intraoperative findings, and subsequent intervention. Results Preoperative hearing loss and imbalance were seen in 70.5 and 64.7%, respectively. Suspicious intraoperative findings included: facial nerve incorporated intimately with the tumor capsule in 12 cases; spontaneous action potentials noted while drilling the bony IAC in 3 cases; and action potentials noted on stimulation of the entire tumor capsule in 10 cases. The mean long-term facial function was House–Brackmann grade II and the mean length of follow-up was 4.86 years. Conclusion FNSs are rare and may be difficult to distinguish from VS preoperatively. Surgical findings that should raise concern include spontaneous action potentials during drilling the bony IAC, absence of a plane of dissection between the facial nerve and tumor, or stimulation of the tumor capsule.

scholarly journals Acidosis facilitates spontaneous sarcoplasmic reticulum Ca2+ release in rat myocardium.

1987 ◽  
Vol 90 (1) ◽  
pp. 145-165 ◽  
Author(s):  
C H Orchard ◽  
S R Houser ◽  
A A Kort ◽  
A Bahinski ◽  
M C Capogrossi ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Action Potentials ◽  
Laser Light ◽  
De Novo ◽  
Resting Membrane Potential ◽  
Resting Tension ◽  
Spontaneous Action ◽  
The Mean ◽  
Spontaneous Action Potentials ◽  
Tissue Motion

Previous studies have shown that acidosis increases myoplasmic [Ca2+] (Cai). We have investigated whether this facilitates spontaneous sarcoplasmic reticulum (SR) Ca2+ release and its functional sequelae. In unstimulated rat papillary muscles, exposure to an acid solution (produced by increasing the [CO2] of the perfusate from 5 to 20%) caused a rapid increase in the mean tissue Cai, as measured by the photoprotein aequorin. This was paralleled by an increase in spontaneous microscopic tissue motion caused by localized Ca2+ myofilament interactions, as monitored in fluctuations in the intensity of laser light scattered by the muscle. In regularly stimulated muscles, acidosis increased the size of the Ca2+ transient associated with each contraction and caused the appearance of Cai oscillations in the diastolic period. In unstimulated single myocytes, acidosis depolarized the resting membrane potential by approximately 5 mV and enhanced the frequency of spontaneous contractile waves. The small sarcolemmal depolarization associated with each contractile wave increased and occasionally initiated spontaneous action potentials. In regularly stimulated myocytes, acidosis caused de novo spontaneous contractile waves between twitches; these waves were associated with a decrease in the amplitude of the subsequent stimulated twitch. Ryanodine (2 microM) abolished all evidence of spontaneous Ca2+ release during acidosis, markedly reduced the acidosis-induced increase in aequorin light, and reduced resting tension. We conclude that acidosis increases the likelihood for the occurrence of spontaneous SR Ca2+ release, which can cause spontaneous action potentials, increase resting tension, and negatively affect twitch tension.

scholarly journals Stimulation of the Salt Receptor of the Blowfly

1966 ◽  
Vol 50 (2) ◽  
pp. 351-357 ◽  
Author(s):  
Howard L. Gillary
Keyword(s):  
Relative Humidity ◽  
Ambient Temperature ◽  
Action Potentials ◽  
Air Interface ◽  
Spontaneous Action ◽  
Spontaneous Action Potentials ◽  
Stimulation Of

The response of the salt receptor of the blowfly increased with increasing ambient temperature. At constant ambient temperature, the response increased as the relative humidity was raised. At low relative humidity, the temperature of the stimulating solution near its air interface was markedly below ambient temperature, due to evaporation. Warming and cooling the tip of the sensillum while recording from its side respectively raised and lowered the frequency of "spontaneous" action potentials of the receptor. The results indicate that the response of the salt receptor is dependent on the temperature of the stimulus. The Q10 is probably several times greater than one.

scholarly journals Conduction velocity of the rabbit facial nerve: a noninvasive functional evaluation

2003 ◽  
Vol 17 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Belmiro Cavalcanti do Egito Vasconcelos ◽  
Cosme Gay Escoda ◽  
Ricardo José de Holanda Vasconcellos ◽  
Riedel Frota Sá Nogueira Neves
Keyword(s):  
Facial Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Action Potentials ◽  
Functional Evaluation ◽  
Surface Electrodes ◽  
Nerve Grafts ◽  
Synthetic Materials ◽  
Facial Nerves ◽  
The Mean

The aim of this study was to evaluate standardized conduction velocity data for uninjured facial nerve and facial nerve repaired with autologous graft nerves and synthetic materials. An evaluation was made measuring the preoperative differences in the facial nerve conduction velocities on either side, and ascertaining the existence of a positive correlation between facial nerve conduction velocity and the number of axons regenerated postoperatively. In 17 rabbits, bilateral facial nerve motor action potentials were recorded pre- and postoperatively. The stimulation surface electrodes were placed on the auricular pavilion (facial nerve trunk) and the recording surface electrodes were placed on the quadratus labii inferior muscle. The facial nerves were isolated, transected and separated 10 mm apart. The gap between the two nerve ends was repaired with autologous nerve grafts and PTFE-e (polytetrafluoroethylene) or collagen tubes. The mean of maximal conduction velocity of the facial nerve was 41.10 m/s. After 15 days no nerve conduction was evoked in the evaluated group. For the period of 2 and 4 months the mean conduction velocity was approximately 50% of the normal value in the subgroups assessed. A significant correlation was observed between the conduction velocity and the number of regenerated axons. Noninvasive functional evaluation with surface electrodes can be useful for stimulating and recording muscle action potentials and for assessing the functional state of the facial nerve.

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