scholarly journals The Labcor Stentless Valved Pulmonary Conduit for RVOT Reconstruction: A 7-Year Experience

2018 ◽  
Vol 66 (S 01) ◽  
pp. S1-S110
Author(s):  
J. Jussli-Melchers ◽  
J. Steer ◽  
C. Grothusen ◽  
J. Logoteta ◽  
J.-H. Hansen ◽  
...  
Keyword(s):  
Pulmonary Conduit

Early valve failure in a first-in-man implant with an Edwards SAPIEN XT valve using the split sheath NovaFlex system in the treatment of a pulmonary conduit stenosis

2013 ◽  
Vol 9 (6) ◽  
pp. 768-768 ◽  
Author(s):  
Jan Harnek ◽  
Peter Hochbergs ◽  
Ulf Thilen ◽  
Johan Holm ◽  
Henrik Bjursten ◽  
...  
Keyword(s):  
Edwards Sapien ◽  
Pulmonary Conduit

Association of Pulmonary Conduit Type and Size With Durability in Infants and Young Children

2013 ◽  
Vol 96 (5) ◽  
pp. 1695-1702 ◽  
Author(s):  
Jeffrey A. Poynter ◽  
Pirooz Eghtesady ◽  
Brian W. McCrindle ◽  
Henry L. Walters ◽  
Paul M. Kirshbom ◽  
...  
Keyword(s):  
Young Children ◽  
Pulmonary Conduit ◽  
Infants And Young Children

Biointegration and Growth of Porcine Valved Pulmonary Conduits in a Sheep Model

2009 ◽  
Vol 17 (4) ◽  
pp. 350-356 ◽  
Author(s):  
Gláucio Furlanetto ◽  
Carlos H Passerino ◽  
Rolland Siegel ◽  
David T Chueng ◽  
Sidney Levitsky ◽  
...  
Keyword(s):  
Growth Potential ◽  
Functional Evaluation ◽  
Sheep Model ◽  
Small Children ◽  
Transvalvular Gradient ◽  
The Mean ◽  
Pulmonary Conduit ◽  
Conduit Wall ◽  
Total Integration ◽  
Valve Area

As there is currently no suitable valved pulmonary conduit for small children, porcine conduits treated by the L-Hydro process were implanted into 9 newborn lambs to investigate growth potential. Of the 8 survivors, 7 were kept alive for 12 months after implantation. The diameter of the conduit and gradient across the valve were evaluated at surgery and at 3 and 9 months postoperatively using bidirectional echocardiographic and angiographic methods. After sacrifice, histological and radiological analyses were performed. The mean weight of the animals was 4.2 ± 1.1 kg at implantation and 43.1 ± 6.2 kg at sacrifice. There was a significant increase in mean valve area from 139.9 ± 18.0 mm2 at implantation to 443.5 ± 89.2 mm2 at 12 months. Pre-sacrifice angiography showed no transvalvular gradient, and radiographic analysis did not reveal significant conduit wall or leaflet calcification in any of the animals. Histological examination of the grafts demonstrated total integration, with native-like intact valve leaflets. Thus functional evaluation, echocardiography, and histology demonstrated growth of the grafts with completely endothelialized and apparently normal pulmonary valve leaflets without calcification.

Cytosolic Ca2+ and adenylyl cyclase responses in phenotypically distinct pulmonary endothelial cells

1997 ◽  
Vol 272 (1) ◽  
pp. L51-L59 ◽  
Author(s):  
T. Stevens ◽  
B. Fouty ◽  
L. Hepler ◽  
D. Richardson ◽  
G. Brough ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Endothelial Permeability ◽  
Cell Types ◽  
Adenylyl Cyclases ◽  
Microvascular Endothelium ◽  
Camp Content ◽  
Pulmonary Endothelial Cells ◽  
Kinase C ◽  
Pulmonary Conduit

Pulmonary microvascular endothelium forms a tighter barrier than does pulmonary artery endothelium; the mechanism of this important phenotypic difference is uncertain. We examined two regulators of endothelial permeability, cytosolic Ca2+ concentration ([Ca2+]i) and adenosine 3',5'-cyclic monophosphate (cAMP), in microvascular (PMVEC) and pulmonary conduit artery (PAEC) endothelium. Both resting and stimulated [Ca2+]i were lower in PMVEC compared with PAEC (resting [Ca2+]i, 94 +/- 7 vs. 123 +/- 8 nM; ATP-stimulated peak, 1.04 +/- 0.14 vs. 1.98 +/- 0.13 microM). Sustained Ca2+ transients in response to either ATP or thapsigargin were reduced in PMVEC compared with PAEC (ATP, 199 +/- 22 vs. 411 +/- 43 nM; thapsigargin, 195 +/- 13 vs. 527 +/- 65 nM), suggesting reduced Ca2+ influx in PMVEC. Reduced Ca2+ influx in PMVEC was confirmed by Mn2+ quenching and patch-clamp experiments. mRNA for Ca(2+)-inhibitable and protein kinase C-stimulated adenylyl cyclases was detected in both cell types. Whereas ATP caused a [Ca2+]i-mediated decrease in cAMP in PAEC, ATP caused a protein kinase C-mediated increase in cAMP in PMVEC. We conclude that PMVEC express a unique phenotype that favors enhanced barrier function through attenuated Ca2+ influx and preservation of cAMP content.

scholarly journals Transcatheter stent-valve implantation in a stenotic pulmonary conduit via a sub-xyphoidian access

2009 ◽  
Vol 36 (3) ◽  
pp. 595-597 ◽  
Author(s):  
Enrico Ferrari ◽  
Christopher Sulzer ◽  
Elena Rizzo ◽  
Ludwig Karl von Segesser
Keyword(s):  
Pulmonary Conduit ◽  
Valve Implantation

Two- and Live/Real Time Three-Dimensional Transthoracic Echocardiographic Assessment of Infective Endocarditis of a Valved Pulmonary Conduit

2014 ◽  
Vol 32 (2) ◽  
pp. 361-364 ◽  
Author(s):  
John C. Gulotta ◽  
Saurabh Gaba ◽  
Serkan Bulur ◽  
Marisa Joson ◽  
Aylin Sungur ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Real Time ◽  
Three Dimensional ◽  
Echocardiographic Assessment ◽  
Pulmonary Conduit

Precise Stent Placement Using the New Siemens Artis Zeego 3D Rotation Angiography in a Stenosis of a Shelhigh Pulmonary Conduit

2010 ◽  
Vol 5 (2) ◽  
pp. 128-130
Author(s):  
Anno Diegeler ◽  
Stefan Fröhner ◽  
Ingo Dähnert
Keyword(s):  
Computed Tomography ◽  
Stent Placement ◽  
Early Onset ◽  
Pulmonary Valve ◽  
Distal Segment ◽  
Ross Procedure ◽  
Pulmonary Conduit ◽  
Artis Zeego

Stenting of the Shelhigh pulmonary conduit was performed 2 years after a Ross procedure because of a stenosis of the distal segment. We used the new Siemens Artis Zeego technology. A precise placement of the stent to release the stenosis within the distal segment simultaneously retaining a competent valve was possible by using the Dyna-computed tomography technology. The early onset of a stenosis of the Shelhigh xenograft in the pulmonary position is alarming, thus, its use can not be recommended for a replacement of the pulmonary valve.

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