European Concerted Action on Anticoagulation (ECAA) - The Multicentre Calibration of Rabbit and Human ECAA Reference Thromboplastins

1996 ◽  
Vol 76 (06) ◽  
pp. 0977-0982 ◽  
Author(s):  
L Poller ◽  
T W Barrowcliffe ◽  
A M H P van den Besselaar ◽  
J Jespersen ◽  
A Tripodi ◽  
...  
Keyword(s):  
Field Study ◽  
European Countries ◽  
Large Field ◽  
Concerted Action

SummaryTwo candidate ECAA reference preparations have been calibrated in a multicentre exercise at 14 representative national laboratories to provide reference thromboplastin for a large field study in 16 European countries. Two preparations were required because of the established differences in ISI arising from the two main routes of calibration via rabbit and human IRP. To be comparable with working reagents in everyday use a human plain recombinant reagent of low ISI and a rabbit plain preparation of moderately high ISI were selected. A precise calibration of the two candidate preparations has been achieved with the manual PT technique and an ISI of 0.95 (SE 0.0078) for the human reagent and 1.67 (SE 0.0322) for the rabbit reagent.

Can Unbiased Financial Advice Steer Retail Investors Towards Efficient Portfolios? Answers from a Large Field Study

2011 ◽  
Author(s):  
Utpal Bhattacharya ◽  
Andreas Hackethal ◽  
Simon Kaesler ◽  
Benjamin Loos ◽  
Steffen Meyer
Keyword(s):  
Field Study ◽  
Large Field ◽  
Financial Advice ◽  
Retail Investors ◽  
Efficient Portfolios

scholarly journals An “Alien” or a Stranger Indeed?

2017 ◽  
Vol 7 (1) ◽  
pp. 41-58
Author(s):  
Mustafa Switat
Keyword(s):  
Field Study ◽  
European Countries ◽  
Eastern European ◽  
Refugee Crisis ◽  
Negative Experiences ◽  
Arab Muslim ◽  
Personal Interactions ◽  
Migration Crisis ◽  
Eastern European Countries ◽  
Muslim Communities

AbstractWith respect to the current migration crisis in Europe, the term “alien” is generally identified with the Arab or Muslim (for many people: Arab = Muslim) communities. The article contains an analysis of the origins, history, and effects of this phenomenon, illustrated with the example of the Arabs in Poland – a country where both of those communities are small, where there are few immigrants as a rule, and which is not directly impacted by the refugee crisis. In general, there were no negative experiences in Polish–Arabic relations, but—due to the lack of knowledge and personal interactions with members of the Arab (Muslim) diaspora—many Poles perceive them as aliens. Why are they aliens? When did they start being aliens? And if they have always been aliens, then are they aliens indeed? In the paper, I will present an analysis of the way members of the Arab diaspora are perceived as aliens and their sense of alienness in Poland. The analysis is based on the field study of this community, with emphasis on the differences between the Arab migration to Poland/Eastern European countries and their migration to other European states. Additionally, a new theory of inclusion of an alien will be presented along with proposals concerning how to “tame” an alien for the sake of a common, conflict-free existence—because “alien” often simply means the unknown and/or the unwanted to be known.

Is Unbiased Financial Advice to Retail Investors Sufficient? Answers from a Large Field Study

2012 ◽  
Vol 25 (4) ◽  
pp. 975-1032 ◽  
Author(s):  
Utpal Bhattacharya ◽  
Andreas Hackethal ◽  
Simon Kaesler ◽  
Benjamin Loos ◽  
Steffen Meyer
Keyword(s):  
Field Study ◽  
Large Field ◽  
Financial Advice ◽  
Retail Investors

Reliability of a Utilization Review Instrument in a Large Field Study

1994 ◽  
Vol 9 (2) ◽  
pp. 68-73 ◽  
Author(s):  
Brenda M. Booth ◽  
Robert L. Ludke ◽  
Eileen M. Fisher
Keyword(s):  
Field Study ◽  
Large Field ◽  
Utilization Review

scholarly journals Brucella melitensis B115-BASED ELISA TO UNRAVEL FALSE POSITIVE SEROLOGIC REACTIONS IN BOVINE BRUCELLOSIS: A FIELD STUDY

2019 ◽  
Author(s):  
adriana trotta ◽  
Mariarosaria Marinaro ◽  
Margie Cirilli ◽  
Alessio Sposato ◽  
Rosanna Adone ◽  
...  
Keyword(s):  
Field Study ◽  
False Positive ◽  
Complement Fixation Test ◽  
Brucella Melitensis ◽  
Extended Period ◽  
Large Field ◽  
Bovine Brucellosis ◽  
Double Positive ◽  
Precise Diagnosis ◽  
Specific Igg

Abstract Background: Brucellosis is a zoonosis whose incidence is not declining worldwide despite the global effort to control the disease. Accurate and precise diagnosis is a crucial step in any prophylaxis program but single tests to unequivocally detect animals infected with Brucella spp. are currently unavailable. In Italy, serological diagnosis of bovine brucellosis is performed with two official tests: a rapid agglutination test (i.e., Rose Bengal Plate test, RBPT) and a complement fixation test (CFT) that detect antibodies directed mainly to the smooth lipopolysaccharide (S-LPS). Neither of the two tests is able to avoid the detection of false positive serological reactions (FPSRs) caused by bacteria sharing S-LPS components with Brucella spp. and responsible for the single reactors (SR) phenomenon. A B. melitensis R strain-based ELISA showed a good diagnostic performance in unravelling FP animals; however, since a limited number of animals were analyzed in that study, a large field study was conducted here to discriminate between Brucella-infected from FP animals, with the final aim of reducing the unnecessary slaughter of the latter. Methods: An ELISA based on a R strain of Brucella, i.e., Brucella melitensis B115, was employed to measure specific IgG responses in a collection of bovine sera (n=648). Sera were obtained from 180 farms (either officially brucellosis-free or not brucellosis-free) recruited during an extended period of time (2014-2018) and were preliminarily assayed with the official tests by the Italian Reference Centers and then subjected to the ELISA. Results: Negative sera, when subjected to the ELISA, gave O.D. values below the cutoff; SR sera, i.e. RBPT positive and CFT negative, as well as double positive (DP) sera, i.e. RBPT and CFT positive, gave O.D. values that were below the cutoff. All positive sera, i.e. from Brucella-infected animals, were RBPT positive and CFT positive (ICFTU ranging from 20 to 1280) and gave ELISA O.D. values above the cutoff. Conclusions: The B. melitensis B115-based ELISA systematically unravelled all false positive (FP) sera while confirming the diagnosis in Brucella-infected animals. Thus, the test employed in the present study may complement the official assays to avoid the costly slaughter of FP animals.

scholarly journals Mitigating Hypothetical Bias: Evidence on the Effects of Correctives from a Large Field Study

2016 ◽  
Vol 68 (3) ◽  
pp. 777-796 ◽  
Author(s):  
Mark A. Andor ◽  
Manuel Frondel ◽  
Colin Vance
Keyword(s):  
Field Study ◽  
Hypothetical Bias ◽  
Large Field
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