Plasma Fibrin Stabilising Factor (F. S. F.) Activity in Normal Subjects and Patients with Chronic Liver Disease

1969 ◽  
Vol 21 (01) ◽  
pp. 134-143 ◽  
Author(s):  
W. D Walls ◽  
M. S Losowsky
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Clinical Improvement ◽  
Quantitative Estimation ◽  
Kinetic Method ◽  
Normal Subjects ◽  
Chronic Liver ◽  
Clinical Severity ◽  
Plasma Fibrinogen ◽  
Normal Range

SummaryA kinetic method for the quantitative estimation of plasma F.S.F. activity is described and discussed.This method was applied to normal subjects and to patients with chronic liver disease. The plasma F.S.F. activity was uninfluenced by either sex or age, and the normal range has been defined.A significant decrease in plasma F.S.F. activity was observed in patients with chronic liver disease. Subnormal levels of activity were found in 25% of such patients but were unrelated to episodes of abnormal haemorrhage. Plasma F.S.F. activity tended to be lower in patients with disease of greater clinical severity. In 2 patients showing clinical improvement there was an increase in plasma F. S. F. activity.It was confirmed that plasma fibrinogen levels increase with age.

Lack of correlation between the laboratory findings and a series of steps in the clinical severity of chronic liver disease

1984 ◽  
Vol 14 (4) ◽  
Author(s):  
Giorgio Cozzolino ◽  
Ciampiero Francica ◽  
Amedeo Lonardo ◽  
Silvio Cigolari ◽  
Luigi Cacciatore
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Clinical Severity ◽  
Laboratory Findings

Nutritional status and quality of life at varying degrees of clinical severity of chronic liver disease

2010 ◽  
Vol 40 (6) ◽  
pp. 581-590 ◽  
Author(s):  
Namita Panagaria ◽  
Kanika Varma ◽  
Sandeep Nijhawan ◽  
R.R. Rai
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Nutritional Status ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Clinical Severity

Quantitative estimation of progression of chronic liver disease using gadoxetate disodium-enhanced magnetic resonance imaging

2018 ◽  
Vol 48 (9) ◽  
pp. 735-745 ◽  
Author(s):  
Akira Yamada ◽  
Yasunari Fujinaga ◽  
Takeshi Suzuki ◽  
Daisuke Komatsu ◽  
Yoshihiro Kitoh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Liver Disease ◽  
Magnetic Resonance ◽  
Chronic Liver Disease ◽  
Quantitative Estimation ◽  
Chronic Liver ◽  
Gadoxetate Disodium ◽  
Resonance Imaging

scholarly journals Ultrasonic measurement of portal and splenic venous flow and their velocities in normal subjects and patients with chronic liver disease.

Kanzo ◽  
1984 ◽  
Vol 25 (10) ◽  
pp. 1281-1287 ◽  
Author(s):  
Masayuki SAITO ◽  
Hidetaka TERABAYASHI ◽  
Katsunori WADA ◽  
Takatsune NAKAYAMA ◽  
Fumio NOMURA ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Normal Subjects ◽  
Ultrasonic Measurement ◽  
Chronic Liver ◽  
Venous Flow

16. A study of correlation between disturbances in calcium-pth-vitamin D axis and clinical severity of non cholestatic chronic liver disease

2018 ◽  
Vol 8 ◽  
pp. S58-S59
Author(s):  
Ravi Anand ◽  
A. Aravind ◽  
K. Premkumar ◽  
K. Caroline Selvi ◽  
Ramkumar Govindarajan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Clinical Severity

Fibrinogen derivatives and platelet activation products in acute and chronic liver disease

1985 ◽  
Vol 68 (6) ◽  
pp. 701-707 ◽  
Author(s):  
R. D. Hughes ◽  
D. A. Lane ◽  
H. Ireland ◽  
P. G. Langley ◽  
A. E. S. Gimson ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Chronic Liver ◽  
Normal Range ◽  
Platelet Factor ◽  
Activation Products ◽  
Platelet Release ◽  
Normal Controls

1. The concentration in plasma of fibrinogen derivatives fibrinopeptide A (FPA) and Bβ1-42 and the platelet release products β-thromboglobulin (βTG) and platelet factor 4 (PF4) have been determined in patients with acute and chronic liver disease. 2. In 21 patients with fulminant hepatic failure on admission in grade III or IV coma the plasma FPA, Bβ1-42, βTG and PF4 levels were significantly increased compared with those in normal control subjects. On heparinization before haemoperfusion the FPA levels returned to the normal range and during resin and charcoal haemoperfusion there were no significant changes in the coagulation or platelet factors, except for a small increase in FPA with charcoal haemoperfusion. 3. In ten patients with compensated chronic liver disease there was a significant increase in Bβ1-42 and βTG levels but not FPA and PF4 as compared with normal controls. 4. Interpretation of the results is complicated by the possible reduced clearance of these proteins as a result of renal failure in some of the patients with fulminant hepatic failure and also by the damaged liver itself. However, these results have confirmed that disseminated intravascular coagulation can occur in both acute and chronic liver disease.

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