Wound Healing, Proceeding of a Symposium held on 12—13 November 1959 at The Royal College of Surgeons of England.

1962 ◽  
Vol 07 (02) ◽  
pp. 389-389
Author(s):  
E Deutsch
Keyword(s):  
2020 ◽  
Vol 103 (5) ◽  
pp. 519-520

The author has informed the editor to correct the acknowledgement in the article(1) as follow: Incorrect acknowledgement in the article: The Surgical Infection Society of Thailand would like to thank the representatives of following health organizations for your kind cooperation and valuable suggestions on this guidelines, namely the Royal College of Surgeons of Thailand, the Royal College of Neurological Surgeons of Thailand, the Royal College of Orthopaedic Surgeons of Thailand, the Royal Thai College of Obstetricians and Gynaecologists, the Royal College of Anesthesiologists of Thailand, the International College of Surgeons (Thailand Section), the Association of General Surgeons of Thailand, the Burn and Wound Healing Association (Thailand), the Thai Perioperative Nurses Association, the Thai Urological Association, the Thai Vascular Association, the Trauma Association of Thailand, the Society of Thoracic Surgeons of Thailand, the Society of Plastic and Reconstructive Surgeons of Thailand, the Thai Hernia Society, the Thai Hepato-Pancreato-Biliary Surgery Society, the Society of Colorectal Surgeons of Thailand, the Upper Gastrointestinal Surgical Club (Thailand), and the Laparoscopic and Endoscopic Surgeons of Thailand. Correct acknowledgement: The Surgical Infection Society of Thailand would like to thank the representatives of following health organizations for your kind cooperation and valuable suggestions on this guidelines, namely the Royal College of Surgeons of Thailand, the Royal College of Neurological Surgeons of Thailand, the Royal College of Orthopaedic Surgeons of Thailand, the Royal Thai College of Obstetricians and Gynaecologists, the Royal College of Anesthesiologists of Thailand, the International College of Surgeons (Thailand Section), the Association of General Surgeons of Thailand, the Burn and Wound Healing Association (Thailand), the Thai Perioperative Nurses Association, the Thai Urological Association, the Thai Vascular Association, the Trauma Association of Thailand, the Society of Thoracic Surgeons of Thailand, the Society of Plastic and Reconstructive Surgeons of Thailand, the Thai Hernia Society, the Thai Hepato-Pancreato-Biliary Surgery Society, the Society of Colorectal Surgeons of Thailand, the Upper Gastrointestinal Surgical Club (Thailand), the Laparoscopic and Endoscopic Surgeons of Thailand, the Infectious Disease Association of Thailand, and the Nosocomial Infection Control Group of Thailand.


Author(s):  
Rick L. Vaughn ◽  
Shailendra K. Saxena ◽  
John G. Sharp

We have developed an intestinal wound model that includes surgical construction of an ileo-cecal patch to study the complex process of intestinal wound healing. This allows approximation of ileal mucosa to the cecal serosa and facilitates regeneration of ileal mucosa onto the serosal surface of the cecum. The regeneration of ileal mucosa can then be evaluated at different times. The wound model also allows us to determine the rate of intestinal regeneration for a known size of intestinal wound and can be compared in different situations (e.g. with and without EGF and Peyer’s patches).At the light microscopic level it appeared that epithelial cells involved in regeneration of ileal mucosa originated from the enlarged crypts adjacent to the intestinal wound and migrated in an orderly fashion onto the serosal surface of the cecum. The migrating epithelial cells later formed crypts and villi by the process of invagination and evagination respectively. There were also signs of proliferation of smooth muscles underneath the migratory epithelial cells.


2020 ◽  
Vol 134 (16) ◽  
pp. 2189-2201
Author(s):  
Jessica P.E. Davis ◽  
Stephen H. Caldwell

Abstract Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.


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