Wound healing. The effects of topical antimicrobial agents

Inflammatory eye diseases are one of the most important problems of ophthalmology. They can be caused by various pathogens of the infection, which is still more often bacterial. Therapy of bacterial inflammatory diseases of the eye involves the use of antibacterial drugs (sulfonamides, antiseptics, nitrofurans, etc.), among which antibiotics are of primary importance. Of this group of drugs, in this review article, special attention is paid to quinolones, mainly synthetic fluoroquinolones, which are distinguished by a wide range of bactericidal action, fairly high efficiency, low level of resistance of microorganisms to it and the frequency of side effects, as well as good tolerability by patients, i.e. they best meet the requirements for modern topical antimicrobial agents. In certain clinical situations and indications, it is advisable to use ophthalmic antiseptics and combined preparations containing several antibiotics of different effects at once, or an antibiotic and a corticosteroid. Key words: infectious and inflammatory eye diseases, antibacterial agents, antibiotics, combined preparations, antiseptics.

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Topical Antimicrobial Agents

Principles and Practice of Pediatric Infectious Disease ◽

10.1016/b978-0-7020-3468-8.50300-x ◽

2008 ◽

pp. 1460-1470

Author(s):

Jane M. Gould ◽

Gail L. Rodgers

Keyword(s):

Antimicrobial Agents ◽

Topical Antimicrobial

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Does Topical Antibiotic Prophylaxis Reduce Post—Tympanostomy Tube Otorrhea?

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949410300110 ◽

1994 ◽

Vol 103 (1) ◽

pp. 54-58 ◽

Cited By ~ 28

Author(s):

Philip Garcia ◽

George A. Gates ◽

Kenneth B. Schechtman

Keyword(s):

Antimicrobial Agents ◽

Antimicrobial Prophylaxis ◽

Meta Analysis ◽

Tympanostomy Tube ◽

Continued Use ◽

The Difference ◽

Prophylactic Use ◽

Low Incidence ◽

Topical Antimicrobial ◽

Patient Studies

Purulent otorrhea is the most common complication of tympanostomy tube (TT) insertion. It may occur in the postoperative period or at any time during the sojourn of the tube. The efficacy of topical antimicrobial prophylaxis against purulent postoperative otorrhea (PPO) has been examined in 5 prospective, randomized studies; all demonstrated a reduction in PPO from topical antimicrobial prophylaxis, but in only 1 study was the difference statistically significant. Because the 5 studies used 2 different experimental designs — By-patient, and by-ear — a single meta-analysis could not be done. However, the by-patient studies met the criteria for meta-analysis, which demonstrated a combined odds ratio of 0.12 (95% confidence interval 0.04 to 0.37, p = .0002). This represents an 85% reduction in otorrhea, which is judged to be clinically as well as statistically significant. We conclude from the available evidence that prophylactic use of topical antimicrobial agents following TT insertion consistently reduces the rate of PPO. However, the low incidence of PPO and the heterogeneity of the published studies prevent making a final judgment for or against the continued use of these agents. Therefore, given that these potentially ototoxic agents are frequently administered to prevent postoperative otorrhea, further study of this subject is warranted. In the meantime, we recommend judicious use of these agents following TT insertion in those cases at higher risk for PPO, namely those with mucoid or purulent effusion.

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