Serum Biomarkers as Predictors of Severity of Injury and Functional Outcome after Acute Traumatic Spinal Cord Injury

2018 ◽  
Author(s):  
A. Raheja ◽  
S. Sinha ◽  
N. Mansoori ◽  
A. Subramanian ◽  
S. Kale
2012 ◽  
Vol 29 (13) ◽  
pp. 2263-2271 ◽  
Author(s):  
Jefferson R. Wilson ◽  
Robert G. Grossman ◽  
Ralph F. Frankowski ◽  
Alexander Kiss ◽  
Aileen M. Davis ◽  
...  

Spinal Cord ◽  
2020 ◽  
Vol 58 (11) ◽  
pp. 1158-1165
Author(s):  
Yuto Ariji ◽  
Tetsuo Hayashi ◽  
Ryosuke Ideta ◽  
Ryuichiro Koga ◽  
Satoshi Murai ◽  
...  

2020 ◽  
Vol 10 (4) ◽  
pp. 183
Author(s):  
Tatiana Martin-Rojas ◽  
Tamara Sastre-Oliva ◽  
Ana Esclarín-Ruz ◽  
Felix Gil-Dones ◽  
Laura Mourino-Alvarez ◽  
...  

Despite promising advances in the medical management of spinal cord injury (SCI), there is still no available effective therapy to repair the neurological damage in patients who experience this life-transforming condition. Recently, we performed a phase II/III placebo-controlled randomized trial of safety and efficacy of growth hormone (GH) treatment in incomplete chronic traumatic spinal cord injury. The main findings were that the combined treatment of GH plus rehabilitation treatment is feasible and safe, and that GH but not placebo slightly improves the SCI individual motor score. Moreover, we found that an intensive and long-lasting rehabilitation program per se increases the functional outcome of SCI individuals. To understand the possible mechanisms of the improvement due to GH treatment (motor score) and due to rehabilitation (functional outcome), we used a proteomic approach. Here, we used a multiple proteomic strategy to search for recovery biomarkers in blood plasma with the potential to predict response to somatropin treatment and to delayed intensive rehabilitation. Forty-six patients were recruited and followed for a minimum period of 1 year. Patients were classified into two groups based on their treatment: recombinant somatropin (0.4 mg) or placebo. Both groups received rehabilitation treatment. Our strategy allowed us to perform one of the deepest plasma proteomic analyses thus far, which revealed two proteomic signatures with predictive value: (i) response to recombinant somatropin treatment and (ii) response to rehabilitation. The proteins implicated in these signatures are related to homeostasis, inflammation, and coagulation functions. These findings open novel possibilities to assess and therapeutically manage patients with SCI, which could have a positive impact on their clinical response.


2017 ◽  
Vol 34 (12) ◽  
pp. 2027-2033 ◽  
Author(s):  
Ludovic Kaminski ◽  
Virginie Cordemans ◽  
Eduard Cernat ◽  
Kouamé Innocent M'Bra ◽  
Jean-Marc Mac-Thiong

2021 ◽  
Author(s):  
Liang Yan ◽  
Dong Wang ◽  
Jinpeng Du ◽  
Dingjun Hao ◽  
Baorong He ◽  
...  

Abstract Study Design. A hospital-based retrospective epidemiological study.Summary of Background Data. TSCI is a highly disabling and deadly injury. Currently, there is little information regarding the epidemiological characteristics for TSCI in Shaanxi.Objective: To describe the demographic and epidemiological characteristics of patients with traumatic spinal cord injury (TSCI) in Shaanxi to help health-related institutions formulate corresponding measures.Methods. We retrospectively reviewed the medical records of the spine centers or orthopedic centers of the four cities in Shaanxi province according to the International Classification of Disease Version 10 (ICD-10) and diagnostic code of TSCI. Variables included gender, age, medical insurance, etiology, occupation, time of injury, level of injury, and severity of injury, multiple injury, treatment, and so on.Results: The study included the medical records of 694 patients with TSCI in 2018. The mean age of patients with TSCI was 48.4±14.9 years, and the male/female ratio was 3.45:1. The major causes of TSCI were high falls (40.2%) and low falls (26.7%). The most common injury site was the cervical spinal cord, accounting for 48.7%. The highest proportion of severity of injury was ASIA Grade D (37.8%). In addition, 74.6% of the patients had spinal fractures, the chest (38.0%) accounted for the highest proportion of all TSCI patients. Furthermore, 27.8% of the patients experienced clinical complications. 530 (76.4%) patients underwent surgery, 323 (46.5%) patients underwent inpatient rehabilitation.Conclusion: There are specific epidemiological characteristics of TSCI patients in Shaanxi, and preventive measures are suggested to be based on the characteristics of the different types of patients with TSCI and focused on high-risk groups.


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