A Two-Step Synthesis of a Novel 7,8-Dihydro-5,8-ethanoindolizine-6,9(5H)-dione
A two-step synthesis of the novel 5,8-dimethyl-7,8-dihydro-5,8-ethanoindolizine-6,9(5H)-dione from 2,3-dimethyl-1,4-benzoquinone is described. The key step of the synthesis of this unusual fused tricyclic system is the intramolecular regiospecific aza-Michael addition of a pyrrole to an activated double bond by reaction with tetrabutylammonium fluoride under mechanochemical conditions.
2019 ◽
Vol 19
(7)
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pp. 875-915
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Keyword(s):
2017 ◽
Vol 15
(30)
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pp. 6447-6450
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2013 ◽
Vol 69
(12)
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pp. o1734-o1735
Keyword(s):