Macrodiolide Library Synthesis of cGAS-STING Inhibitors

Synfacts ◽

10.1055/s-0040-1720789 ◽

2021 ◽

Vol 17 (09) ◽

pp. 1047

Keyword(s):

Library Synthesis

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Faculty Opinions recommendation of Asymmetric Catalysis in Diversity-Oriented Organic Synthesis: Enantioselective Synthesis of 4320 Encoded and Spatially Segregated Dihydropyrancarboxamides We thank the National Institute of General Medical Sciences (GM-52067) for support of this research, and Dr. John Tallarico and Max Narovlyansky at the ICCB for generously providing resin for the library synthesis. We thank Dr. Helen Blackwell and Lucy Pérez for expert help with library encoding. We are grateful to Prof. Eric Jacobsen and Prof. Scott Denmark for the use of their chiral stationary phase high pressure liquid chromatograph and supercritical fluid chromatograph, respectively. The Harvard ICCB is supported by Merck & Co., Merck KGaA, the Keck Foundation, and the National Cancer Institute. R.A.S. is a Research Associate and S.L.S. is an Investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1003104.32305 ◽

2002 ◽

Author(s):

Stefan Bräse

Keyword(s):

Asymmetric Catalysis ◽

Chiral Stationary Phase ◽

Howard Hughes Medical Institute ◽

Harvard University ◽

Medical Institute ◽

Library Synthesis ◽

Medical Sciences ◽

Liquid Chromatograph ◽

Research Associate ◽

High Pressure Liquid Chromatograph

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Chemoselective High-Throughput Purification Mediated by Solid-Supported Reagents Its Application to the First 6,9-Disubstituted Purine Library Synthesis

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207003331779 ◽

2000 ◽

Vol 3 (2) ◽

pp. 125-129 ◽

Author(s):

Kyungjin Kim ◽

Warren McComas

Keyword(s):

High Throughput ◽

Library Synthesis

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Cholesterol-Modified Oligonucleotides as Internal Reaction Controls during DNA-Encoded Chemical Library Synthesis

Bioconjugate Chemistry ◽

10.1021/acs.bioconjchem.1c00045 ◽

2021 ◽

Vol 32 (4) ◽

pp. 667-671

Author(s):

Guanyu Yang ◽

Dou He ◽

Yijun Zhu ◽

Weiwei Zhu ◽

Yang Tan ◽

...

Keyword(s):

Modified Oligonucleotides ◽

Library Synthesis ◽

Chemical Library ◽

Internal Reaction

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Microwave-Assisted Solid-Phase Synthesis (MASS): Parallel and Combinatorial Chemical Library Synthesis

10.1002/chin.200407314 ◽

2004 ◽

Vol 35 (7) ◽

Author(s):

Fahad Al-Obeidi ◽

Richard E. Austin ◽

John F. Okonya ◽

Daniel R. S. Bond

Keyword(s):

Solid Phase Synthesis ◽

Solid Phase ◽

Library Synthesis ◽

Chemical Library ◽

Phase Synthesis ◽

Microwave Assisted

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Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process

Monatshefte für Chemie - Chemical Monthly ◽

10.1007/s00706-015-1605-6 ◽

2015 ◽

Vol 147 (3) ◽

pp. 523-532 ◽

Author(s):

Michael Schön ◽

Dominik Dreier ◽

Michael Schnürch ◽

Marko D. Mihovilovic

Keyword(s):

Library Synthesis ◽

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Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

Scientific Reports ◽

10.1038/srep10916 ◽

2015 ◽

Vol 5 (1) ◽

Author(s):

Alexander Litovchick ◽

Christoph E. Dumelin ◽

Sevan Habeshian ◽

Diana Gikunju ◽

Marie-Aude Guié ◽

...

Keyword(s):

Library Synthesis ◽

Chemical Ligation

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Identification, library synthesis and anti-vibriosis activity of 2-benzyl-4-chlorophenol from cultures of the marine bacterium Shewanella halifaxensis

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2016.05.002 ◽

2016 ◽

Vol 26 (13) ◽

pp. 3086-3088 ◽

Author(s):

Sarah L. Moore ◽

Lucile Berthomier ◽

Chriselle D. Braganza ◽

Joanna K. MacKichan ◽

Jason L. Ryan ◽

...

Keyword(s):

Marine Bacterium ◽

Library Synthesis

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Monitoring solution-phase combinatorial library synthesis by capillary electrophoresis

Biotechnology and Bioengineering ◽

10.1002/(sici)1097-0290(1998)61:3<169::aid-cc4>3.0.co;2-6 ◽

1999 ◽

Vol 61 (3) ◽

pp. 169-177 ◽

Author(s):

Hans J. Gaus ◽

Pei-Pei Kung ◽

Doug Brooks ◽

P. Dan Cook ◽

Lendell L. Cummins

Keyword(s):

Capillary Electrophoresis ◽

Combinatorial Library ◽

Solution Phase ◽

Library Synthesis

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Elucidating the Structure-Property Relationships of Donor-π-Acceptor Dyes for Dye-Sensitized Solar Cells (DSSCs) through Rapid Library Synthesis by a One-Pot Procedure

Chemistry - A European Journal ◽

10.1002/chem.201402093 ◽

2014 ◽

Vol 20 (34) ◽

pp. 10685-10694 ◽

Author(s):

Shinichiro Fuse ◽

Sakae Sugiyama ◽

Masato M. Maitani ◽

Yuji Wada ◽

Yuhei Ogomi ◽

...

Keyword(s):

Solar Cells ◽

Dye Sensitized Solar Cells ◽

Library Synthesis ◽

Structure Property ◽

One Pot ◽

Dye Sensitized ◽

Structure Property Relationships ◽

Sensitized Solar Cells

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Synthesis of 2-Arylbenzothiazoles by DDQ-Promoted Cyclization of Thioformanilides: A Solution-Phase Strategy for Library Synthesis.

10.1002/chin.200729118 ◽

2007 ◽

Vol 38 (29) ◽

Author(s):

D. Subhas Bose ◽

Mohd. Idrees ◽

Bingi Srikanth

Keyword(s):

Solution Phase ◽

Library Synthesis

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