Lipidol Cone-Beam Computed Tomography Volume Measurements for Hepatocellular Carcinoma Compared to Conventional Computed Tomography after Transarterial Chemoembolization

Abstract Background Inoperable hepatocellular carcinoma (HCC) is treated by conventional transarterial chemoembolization (cTACE) using cone-beam computed tomography (CBCT) or digital subtraction angiography (DSA). We compared patient survival outcomes between CBCT-cTACE with automated tumor-feeder detection (AFD) software and DSA-cTACE alone in inoperable HCC patients. Methods We reviewed the data of 337 HCC patients treated by CBCT-cTACE or DSA-cTACE between January 2015 and December 2019. Treatment response, progression-free survival (PFS), overall survival (OS), and complications between the CBCT-cTACE and DSA-cTACE groups were compared. Univariate and multivariate logistic regression analyses examined the potential prognostic factors affecting survival after chemoembolization. Results Tumor response rates in complete response, partial response, and stable disease at 1 month were 67%, 28%, and 4% in the CBCT-cTACE group and 22%, 48%, and 9% in the DSA-cTACE group, respectively. OS rates of patients in the CBCT-cTACE versus DSA-cTACE groups were 87% versus 54%, 44% versus 15%, and 34% versus 7% at 1, 3, and 5 years, respectively. The CBCT-cTACE group had significantly improved PFS (p < 0.001) and OS (p < 0.001). Multivariate analysis showed that CBCT with AFD software was an independent factor associated with longer OS (hazard ratio, 0.38; p < 0.001). Conclusions Compared with conventional DSA, combining selective cTACE with CBCT and AFD software leads to better tumor response and prolongs OS in patients with inoperable HCC.

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Lipiodol retention pattern assessed by cone beam computed tomography during conventional transarterial chemoembolization of hepatocellular carcinoma: accuracy and correlation with response

Cancer Imaging ◽

10.1186/s40644-016-0090-4 ◽

2016 ◽

Vol 16 (1) ◽

Cited By ~ 4

Author(s):

Jungang Hu ◽

Majid Maybody ◽

Guang Cao ◽

Xiao Wang ◽

Hui Chen ◽

...

Keyword(s):

Computed Tomography ◽

Hepatocellular Carcinoma ◽

Cone Beam Computed Tomography ◽

Transarterial Chemoembolization ◽

Cone Beam

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Comparison between C-arm cone beam computed tomography and interventional angiography in transarterial chemoembolization of hepatocellular carcinoma

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-019-0053-4 ◽

2019 ◽

Vol 50 (1) ◽

Author(s):

Ibraheim Ahmed Diab ◽

Shaimaa Abdel-hamid Hassanein ◽

Hala Hafez Mohamed

Keyword(s):

Computed Tomography ◽

Hepatocellular Carcinoma ◽

Cone Beam Computed Tomography ◽

Vascular Anatomy ◽

Cone Beam ◽

Focal Lesion ◽

Focal Lesions ◽

Conventional Angiography ◽

Interventional Angiography ◽

Cross Sectional

Abstract Background Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy of adults. One of the established treatment procedures performed worldwide for HCC is transcatheter arterial chemoembolization (TACE). By using conventional angiography in TACE, we can detect and identify the vascular anatomy of the liver through obtaining 2D images. Recently C-arm cone beam computed tomography (CBCT) is introduced for obtaining cross-sectional and three-dimensional (3D) images for better visualization of small tumors and their feeding arteries. Results The number of detected focal lesions by angiography was 51 compared to 87 focal lesion detected by CBCT; of those, 45 and 77 were active lesions by both procedures respectively. For lesions, less than 1 cm CBCT detected 23 lesions while angiography detected only one lesion. Angiography detected 87 feeding arterial branch while cone beam CT-HA detected 130 branches to the same number of target lesion. Feeder tractability and confidence were better by CBCT. Conclusion CBCT is superior to angiography in tumor detectability, detection of lesions less than 1 cm, feeder detection, and feeder traction; however, conventional angiography and DSA are irreplaceable. Thus, combination of CBCT with angiography during TACE produces better results and less complication.

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Comparison of Hand and Semiautomatic Tracing Methods for Creating Maxillofacial Artificial Organs using Sequences of Computed Tomography (CT) and Cone Beam Computed Tomography (CBCT) Images

The International Journal of Artificial Organs ◽

10.5301/ijao.5000580 ◽

2017 ◽

Vol 40 (6) ◽

pp. 307-312 ◽

Cited By ~ 3

Author(s):

Bence T. Szabo ◽

Seçil Aksoy ◽

Gabor Repassy ◽

Krisztian Csomo ◽

Csaba Dobo-Nagy ◽

...

Keyword(s):

Computed Tomography ◽

Cone Beam Computed Tomography ◽

Volume Measurement ◽

Artificial Organs ◽

Cone Beam ◽

Artificial Organ ◽

Volume Determination ◽

Measurement Results ◽

Volume Measurements ◽

Maxillary Sinuses

Introduction The aim of this study was to compare the paranasal sinus volumes obtained by manual and semiautomatic imaging software programs using both CT and CBCT imaging. Methods 121 computed tomography (CT) and 119 cone beam computed tomography (CBCT) examinations were selected from the databases of the authors’ institutes. The Digital Imaging and Communications in Medicine (DICOM) images were imported into 3-dimensonal imaging software, in which hand mode and semiautomatic tracing methods were used to measure the volumes of both maxillary sinuses and the sphenoid sinus. The determined volumetric means were compared to previously published averages. Results Isometric CBCT-based volume determination results were closer to the real volume conditions, whereas the non-isometric CT-based volume measurements defined coherently lower volumes. By comparing the 2 volume measurement modes, the values gained from hand mode were closer to the literature data. Furthermore, CBCT-based image measurement results corresponded to the known averages. Conclusions Our results suggest that CBCT images provide reliable volumetric information that can be depended on for artificial organ construction, and which may aid the guidance of the operator prior to or during the intervention.

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