11β-Hydroxysteroid Dehydrogenase Type 1: An Explanation of the Metabolic Syndrome - Cushing’s Disease Paradox?

2004 ◽  
Vol 35 (10) ◽  
pp. 628-648
Keyword(s):  
Metabolic Syndrome ◽  
Cushing’S Disease ◽  
Hydroxysteroid Dehydrogenase ◽  
Cushing's Disease ◽  
The Metabolic Syndrome

Hexose-6-phosphate dehydrogenase in the endoplasmic reticulum

2010 ◽  
Vol 391 (1) ◽  
Author(s):  
Silvia Senesi ◽  
Miklos Csala ◽  
Paola Marcolongo ◽  
Rosella Fulceri ◽  
Jozsef Mandl ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Endoplasmic Reticulum ◽  
Pentose Phosphate Pathway ◽  
Hydroxysteroid Dehydrogenase ◽  
Pyridine Nucleotide ◽  
Pentose Phosphate ◽  
The Metabolic Syndrome ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract Hexose-6-phosphate dehydrogenase (H6PD) is a luminal enzyme of the endoplasmic reticulum that is distinguished from cytosolic glucose-6-phosphate dehydrogenase by several features. H6PD converts glucose-6-phosphate and NADP+ to 6-phosphogluconate and NADPH, thereby catalyzing the first two reactions of the pentose-phosphate pathway. Because the endoplasmic reticulum has a separate pyridine nucleotide pool, H6PD provides NADPH for luminal reductases. One of these enzymes, 11β-hydroxysteroid dehydrogenase type 1 responsible for prereceptorial activation of glucocorticoids, has been the focus of much attention as a probable factor in the pathomechanism of several human diseases including insulin resistance and the metabolic syndrome. This review summarizes recent advances related to the functions of H6PD.

scholarly journals 11β-Hydroxysteroid Dehydrogenase Type 1 and the Metabolic Syndrome

10.5772/28641 ◽  
2011 ◽  
Author(s):  
Cidalia D. ◽  
Maria J. ◽  
Isabel Azevedo ◽  
Rosario Monteiro
Keyword(s):  
Metabolic Syndrome ◽  
Hydroxysteroid Dehydrogenase ◽  
The Metabolic Syndrome

scholarly journals Beyond the metabolic syndrome: Visceral and marrow adipose tissues impair bone quantity and quality in Cushing’s disease

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0223432 ◽  
Author(s):  
Sérgio Luchini Batista ◽  
Iana Mizumukai de Araújo ◽  
Adriana Lelis Carvalho ◽  
Maria Augusta V. S. D. Alencar ◽  
Andressa K. Nahas ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Adipose Tissues ◽  
The Metabolic Syndrome ◽  
Bone Quantity
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