Hypericum extract LI160 for depression with atypical features

Abstract Background Coronavirus disease (COVID-19) is a respiratory syndrome with a variable degree of severity. Imaging is a vital component of disease monitoring and follow-up in coronavirus pulmonary syndromes. The study of temporal changes of CT findings of COVID-19 pneumonia can help in better understanding of disease pathogenesis and prediction of disease prognosis. In this study, we aim to determine the typical and atypical CT imaging features of COVID-19 and discuss the association of typical CT imaging features with the duration of the presenting complaint and patients’ age. Results The lesions showed unilateral distribution in 20% of cases and bilateral distribution in 80% of cases. The lesions involved the lower lung lobes in 30% of cases and showed diffuse involvement in 58.2% of cases. The lesions showed peripheral distribution in 74.5% of cases. The most common pattern was multifocal ground glass opacity found in 72.7% of cases. Atypical features like cavitation and pleural effusion can occur early in the disease course. There was significant association between increased number of the lesions, bilaterality, diffuse pattern of lung involvement and older age group (≥ 50 years old) and increased duration of presenting complaint (≥ 4 days). There was significant association between crazy-paving pattern and increased duration of presenting complaint. No significant association could be detected between any CT pattern and increased patient age. Conclusion The most common CT feature of COVID-19 was multifocal ground glass opacity. Atypical features like cavitation and pleural effusion can occur early in the course of the disease. Our cases showed more extensive lesions with bilateral and diffuse patterns of distribution in the older age group and with increased duration of presenting complaint. There was a significant association between crazy-paving pattern and increased duration of presenting complaint. No significant association could be detected between any CT pattern and increased patient age.

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Kidney Biopsy in Type 2 Diabetes: A Multicenter Cross-Sectional Study

American Journal of Nephrology ◽

10.1159/000514259 ◽

2021 ◽

pp. 1-10

Author(s):

Jonathan M. Chemouny ◽

Mickaël Bobot ◽

Aurélie Sannier ◽

Valentin Maisons ◽

Noémie Jourde-Chiche ◽

...

Keyword(s):

Type 2 Diabetes ◽

Total Population ◽

Cross Sectional Study ◽

Rapid Progression ◽

Hypertensive Nephropathy ◽

Cross Sectional ◽

Recent Onset ◽

Atypical Features ◽

Retinal Examination

Introduction: Kidney biopsies (KBs) are performed in patients with type 2 diabetes (T2D) to diagnose non-diabetic or hypertensive kidney disease (NDHKD) potentially requiring specific management compared to diabetic and or hypertensive nephropathy (absence of NDHKD). Indications for KB are based on the presence of atypical features compared to the typical course of diabetic nephropathy. In this study, we assessed the association of different patterns of atypical features, or KB indications, with NDHKD. Methods: Native KBs performed in patients with T2D were analyzed. Data were collected from the patients’ records. KB indications were determined according to the presence of different atypical features considered sequentially: (1) presence of any feature suggesting NDHKD which is not among the following ones, (2) recent onset of nephrotic syndrome, (3) low or rapidly declining estimated glomerular filtration rate (eGFR), (4) rapid increase in proteinuria, (5) short duration of diabetes, (6) presence of hematuria, or (7) normal retinal examination. Results: Among the 463 KBs analyzed, NDHKD was diagnosed in 40% of the total population and 54, 40, 24, and 7% of the KBs performed for indications 1–4 respectively. Conversely, no patient who underwent KB for indications 5–7 displayed NDHKD. Logistic regression analyses identified eGFRCKD-EPI >15 mL/min/1.73 m2, urinary protein-to-Cr ratio <0.3 g/mmol, hematuria, HbA1c <7%, and diabetes duration <5 years as predictors of NDHKD, independently from the indication group. Conclusion: NDHKD is frequent in T2D. Despite the association of hematuria with NDHKD, our results suggest that presence of hematuria and absence of DR are insufficient to indicate KB in the absence of concurrent atypical features. Conversely, rapid progression of proteinuria and rapid deterioration of eGFR are major signals of NDHKD.

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Understanding the Uncanny: Both Atypical Features and Category Ambiguity Provoke Aversion toward Humanlike Robots

Frontiers in Psychology ◽

10.3389/fpsyg.2017.01366 ◽

2017 ◽

Vol 8 ◽

Cited By ~ 20

Author(s):

Megan K. Strait ◽

Victoria A. Floerke ◽

Wendy Ju ◽

Keith Maddox ◽

Jessica D. Remedios ◽

...

Keyword(s):

The Uncanny ◽

Atypical Features

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Efficacy of a hypericum extract (STW3-VI) – A reanalysis

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.732 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S535-S535

Author(s):

J. Mueller ◽

C. Kolb

Keyword(s):

Data Structure ◽

Positive Predictive Value ◽

Predictive Value ◽

Sleep Disturbances ◽

Item Analysis ◽

Significant Treatment ◽

Single Item ◽

Early Improvement ◽

End Of Treatment ◽

Hypericum Extract

IntroductionThe course of depression during therapy in studies is usually monitored by scales like HAMD. Also the course of single items of the HAMD during therapy might be of specific interest as some symptoms are of highly predictive value. Furthermore early improvement during antidepressive therapy is a new aspect which came into the focus.ObjectivesThe objectives of this study were to reanalyze clinical data regarding early improvement as well as specific symptoms or symptom cluster – like sleep disturbances.AimsThe aim of this study was to get deeper insight into the data structure of 2 RCTs (n = 398, 42 days treatment) comparing the efficacy of a hypericum extract (STW3-VI/900 mg once daily) to Placebo.MethodsData structure was evaluated by comparing the total scores of the HAMD-17 to a single item analysis and by calculating the factorial structure of the end of treatment data. The treatment potential was evaluated by calculating a positive predictive value from day 7 to the end of treatment. ANCOVA, factor analysis and regression methods were used.ResultsThe single item analyses were widely comparable to the highly significant treatment differences of the total scores as it were the calculated subscales. The positive predictive value of the treatment was about 75%.ConclusionsThe results underline the elsewhere proven treatment efficacy of STW3-VI regarding several new subscale aspects.Disclosure of interestCOI: The authors are employees of Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany.

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