Antenatal Diagnosis and Management of Fetomaternal Alloimmune Thrombocytopenia

1995 ◽  
Vol 12 (05) ◽  
pp. 333-335 ◽  
Author(s):  
Jan Dickinson ◽  
Lorraine Marshall ◽  
John Phillips ◽  
Andrew Barr
2002 ◽  
Vol 20 (6) ◽  
pp. 623-626 ◽  
Author(s):  
F. Cuillier ◽  
S. Samperiz ◽  
R. Testud ◽  
P. Fossati

Blood ◽  
1988 ◽  
Vol 72 (1) ◽  
pp. 340-343
Author(s):  
C Kaplan ◽  
F Daffos ◽  
F Forestier ◽  
WL Cox ◽  
D Lyon-Caen ◽  
...  

Neonatal alloimmune thrombocytopenia (NAIT) can cause severe bleeding in the central nervous system (CNS) and death or severe neurologic sequelae. The expression of the PLA1 antigen is detectable as early as 19 weeks of gestation. Alloimmunization can therefore lead to fetal thrombocytopenia very early in pregnancy. Until recently, we have had no means of detecting and assessing the severity of fetal thrombocytopenia during pregnancy. The level of the maternal antibody is not of a predictable value since 20% of the mothers had no circulating antibodies in our series. An alternative approach is to carry out investigations on fetal blood samplings. This management leads to an exact knowledge of the fetal status and antenatal diagnosis is feasible as early as the 21st week of gestation. Early diagnosis facilitates appropriate management and makes possible such therapeutic options as in utero maternal platelet transfusions. We report our experience in the antenatal diagnosis and management of nine cases with in utero transfusion in the six cases with severe thrombocytopenia. All neonates did well, with no signs of bleeding at birth. No side effects of therapy were noted after a period ranging from 6 months to 3 years.


1987 ◽  
Vol 157 (5) ◽  
pp. 1255-1257 ◽  
Author(s):  
John F. Rodis ◽  
Anthony M. Vintzileos ◽  
Winston A. Campbell ◽  
Jeffrey L. Deaton ◽  
Fred Fumia ◽  
...  

1988 ◽  
Vol 8 (5) ◽  
pp. 329-331 ◽  
Author(s):  
Lauren Lynch ◽  
James Bussel ◽  
James D. Goldberg ◽  
Usha Chitkara ◽  
Isabelle Wilkins ◽  
...  

2012 ◽  
Vol 40 (S1) ◽  
pp. 295-296
Author(s):  
A. Godinho ◽  
C. Nunes ◽  
R. Carvalho ◽  
M. Janeiro ◽  
A. M. Alves

2017 ◽  
Vol 31 (2) ◽  
pp. 245-250 ◽  
Author(s):  
Murat Aykut Ozek ◽  
Pinar Calis ◽  
Merih Bayram ◽  
Deniz Karcaaltincaba

1998 ◽  
Vol 11 (2) ◽  
pp. 147-148 ◽  
Author(s):  
J. M. Fernandez Moya ◽  
S. Cifuentes Sulzberger ◽  
J. Díaz Recaséns ◽  
C. Ramos ◽  
R. Sanz ◽  
...  

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