The Genetics of Juvenile-Onset-Type Diabetes Mellitus

1. The response of plasma noradrenaline, arterial blood pressure and heart rate to sustained handgrip at 30% of maximal voluntary contraction was studied in patients with long-term juvenile-onset-type diabetes mellitus and healthy subjects of comparable age. 2. There was no significant difference between the intensity and duration of handgrip in diabetic patients and healthy subjects. 3. Sustained handgrip produced an increase in plasma concentration of noradrenaline both in diabetic and healthy subjects but the response in the diabetic subjects was significantly less. 4. The increase in systolic blood pressure during handgrip was significantly greater in diabetic subjects than in normal subjects. The increases in diastolic and mean blood pressure did not differ significantly. 5. The increase in heart rate during handgrip was greater in healthy subjects than in diabetic subjects. The response was smaller in diabetic patients with retinopathy than in the patients without retinopathy. 6. The sustained handgrip test may be useful for the diagnosis of abnormal sympathetic nervous system and haemodynamic responsiveness in diabetic patients.

Download Full-text

Clinical application of a glucoside-hydrolase inhibitor (Bay g 5421) to patients with hyperlipidemia and maturity-onset type diabetes mellitus.

The Tohoku Journal of Experimental Medicine ◽

10.1620/tjem.130.243 ◽

1980 ◽

Vol 130 (3) ◽

pp. 243-252 ◽

Cited By ~ 1

Author(s):

YOSHISUKE MARUHAMA ◽

YOSHIO GOTO

Keyword(s):

Diabetes Mellitus ◽

Type Diabetes ◽

Type Diabetes Mellitus ◽

Clinical Application ◽

Onset Type

Download Full-text

Sustained attention deficits in adults with juvenile-onset type 1 diabetes mellitus

Psychosomatic Medicine ◽

10.1097/psy.0000000000000992 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Wenjing Zou ◽

Jing He ◽

Yuzhuo Liu ◽

Jiang Zhu ◽

Fang Liu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Sustained Attention ◽

Attention Deficits ◽

Juvenile Onset ◽

Onset Type

Download Full-text

Familial Patterns of Inheritance of Diabetes Mellitus. Maturity-Onset Type Diabetes of Young People (MODY)

Treatment of EARLY DIABETES - Advances in Experimental Medicine and Biology ◽

10.1007/978-1-4615-9110-8_10 ◽

1979 ◽

pp. 59-65 ◽

Cited By ~ 1

Author(s):

M. C. Cloutier ◽

S. S. Fajans

Keyword(s):

Diabetes Mellitus ◽

Type Diabetes ◽

Young People ◽

Onset Type ◽

Inheritance Of Diabetes ◽

Familial Patterns

Download Full-text

Therapy of II Type Diabetes Mellitus: Efficiency is Proved by Time

Family Medicine ◽

10.30841/2307-5112.5.2016.248620 ◽

2016 ◽

pp. 13-14

Author(s):

Oksana Muravleva

Keyword(s):

Diabetes Mellitus ◽

Type Diabetes ◽

Type Diabetes Mellitus ◽

Metformin Hydrochloride ◽

Topical Issue

The article deals with the topical issue of endocrinology 1 diabetes mellitus (DM), which is spread with catastrophic speed and becoming a real epidemic of XXI century. Metformin hydrochloride for many years has proved its effectiveness in the therapy of II type diabetes mellitus. Therefore, Metformin hydrochloride is the main treatment for diabetes II type.

Download Full-text