High Risk of Cerebral-Vein Thrombosis in Carriers of a Prothrombin-Gene Mutation and in Users of Oral Contraceptives

1998 ◽  
Vol 338 (25) ◽  
pp. 1793-1797 ◽  
Author(s):  
Ida Martinelli ◽  
Elisabetta Sacchi ◽  
Gianluca Landi ◽  
Emanuela Taioli ◽  
Francesca Duca ◽  
...  
Keyword(s):  
High Risk ◽  
Gene Mutation ◽  
Oral Contraceptives ◽  
Cerebral Vein ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis ◽  
Prothrombin Gene Mutation ◽  
Prothrombin Gene

Recombinant Plasminogen Activator Therapy for Cerebral Vein Thrombosis in a Child Carrier of Prothrombin Gene Mutation

2002 ◽  
Vol 24 (9) ◽  
pp. 769-771 ◽  
Author(s):  
Luigi Tarani ◽  
Metello Iacobini ◽  
Valerio De Stefano ◽  
Maria Paola Smacchia ◽  
Maria Cristina Tozzi ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Gene Mutation ◽  
Cerebral Vein ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis ◽  
Prothrombin Gene Mutation ◽  
Prothrombin Gene

Oral Contraceptives Are a Risk Factor for Cerebral Vein Thrombosis

1996 ◽  
Vol 76 (03) ◽  
pp. 477-478 ◽  
Author(s):  
I Martinelli ◽  
F R Rosendaal ◽  
J P Vandenbroucke ◽  
P M Mannucci
Keyword(s):  
Risk Factor ◽  
Oral Contraceptives ◽  
Cerebral Vein ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis

scholarly journals A case of recurrent cerebral vein thrombosis with protein C gene mutation identified

2018 ◽  
Vol 58 (12) ◽  
pp. 764-766
Author(s):  
Yumeho Sugahara ◽  
Natsuki Ono ◽  
Eriko Morishita ◽  
Hiroshi Takashima
Keyword(s):  
Gene Mutation ◽  
Protein C ◽  
Cerebral Vein ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis

Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis

Blood ◽  
2006 ◽  
Vol 107 (7) ◽  
pp. 2766-2773 ◽  
Author(s):  
Francesco Dentali ◽  
Mark Crowther ◽  
Walter Ageno
Keyword(s):  
Oral Contraceptives ◽  
Meta Analysis ◽  
Factor V Leiden ◽  
Cochrane Library ◽  
Cerebral Vein ◽  
Factor V ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis ◽  
Increased Risk ◽  
Study Characteristics

AbstractRecent studies suggest that thrombophilic abnormalities and the use of oral contraceptives (OCs) are the leading causes of cerebral vein thrombosis (CVT). The purpose of this study was to assess the association between CVT and thrombophilic states, OCs, and their interaction. For data sources, we used the MEDLINE, EMBASE, and Cochrane Library databases (January 1994 to March 2005), reference lists of retrieved articles, and contact with content experts. We selected studies comparing the prevalence of OC use and the prevalence of prothrombitic abnormalities in patients with CVT compared with healthy controls. Two reviewers independently selected studies and extracted study characteristics, quality, and outcomes. Odds ratios (ORs) were calculated for each trial and pooled using the Mantel-Haenszel method. Seventeen studies were included. There was an increased risk of CVT in patients using OCs (OR 5.59; 95% confidence interval [CI] 3.95 to 7.91; P < .001), and in patients with factor V Leiden (OR 3.38; 95% CI 2.27 to 5.05; P < .001), with mutation G20 210A of prothrombin (OR 9.27; 95% CI 5.85 to 14.67; P < .001) and with hyperhomocysteinemia (OR 4.07; 95% CI 2.54 to 6.52; P < .001). We concluded that OC users, and patients with factor V Leiden, the prothrombin G20 120A mutation, and hyperhomocysteinemia are at a significantly increased risk of CVT.

Risk of cerebral vein thrombosis and oral contraceptives

The Lancet ◽  
1998 ◽  
Vol 352 (9124) ◽  
pp. 326 ◽  
Author(s):  
I Martinelli ◽  
E Taioli ◽  
D Palli ◽  
PM Mannucci
Keyword(s):  
Oral Contraceptives ◽  
Cerebral Vein ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis

Homozygous 20210G/A Prothrombin Gene Mutation Associated with Bilateral Iliac Vein Thrombosis: A Case Report

2001 ◽  
Vol 104 (4) ◽  
pp. 293-296 ◽  
Author(s):  
Amparo Vayá ◽  
Milagros Garcı&#x;a ◽  
Yolanda Mira ◽  
Fernando Ferrando ◽  
Piedad Villa ◽  
...  
Keyword(s):  
Case Report ◽  
Gene Mutation ◽  
Iliac Vein ◽  
Vein Thrombosis ◽  
Prothrombin Gene Mutation ◽  
Prothrombin Gene ◽  
Iliac Vein Thrombosis

Cerebral Vein Thrombosis not Related to Use of Oral Contraceptives in a 7-year-old Child Carrier of the Prothrombin 20210A Allele

1999 ◽  
Vol 81 (06) ◽  
pp. 991-992 ◽  
Author(s):  
K. Paciaroni ◽  
P. Chiusolo ◽  
I. Casorelli ◽  
E. Rossi ◽  
L. Teofili ◽  
...  
Keyword(s):  
Oral Contraceptives ◽  
Cerebral Vein ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis ◽  
Prothrombin 20210A
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