Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor

2001 ◽  
Vol 344 (14) ◽  
pp. 1052-1056 ◽  
Author(s):  
Heikki Joensuu ◽  
Peter J. Roberts ◽  
Maarit Sarlomo-Rikala ◽  
Leif C. Andersson ◽  
Pekka Tervahartiala ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Gastrointestinal Stromal Tumor ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Stromal Tumor

scholarly journals Gastrointestinal Stromal Tumor of the Tongue

2013 ◽  
Vol 28 (1) ◽  
pp. 28-33
Author(s):  
Andrie Jeremy Formanez ◽  
Grace Naomi B. Galvan-Bravo
Keyword(s):  
Tyrosine Kinase ◽  
Gastrointestinal Stromal Tumor ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Stromal Tumor ◽  
Surgical Removal ◽  
Repeat Surgery ◽  
Complete Surgical Resection ◽  
Tender Mass ◽  
Immunohistochemical Studies

Objective: To report a case of a gastrointestinal stromal tumor presenting as a recurrent tongue mass Methods: Study Design: Case Report Setting: Tertiary Public Hospital Participant: One patient Results: A 40-year-old Filipino soldier from Camarines Sur presented with a recurrent tongue mass two years after excision of a progressively-enlarging, firm, fixed, non-tender mass at the left posterior third of the tongue diagnosed as a Schwannoma. Repeat surgery involved partial glossectomy via midline mandibular swing. Final histopathologic report after immunohistochemical studies for CD117, SMA, and S100 was extraintestinal gastrointestinal stromal tumor of the tongue. The patient was started on the c-kit tyrosine kinase inhibitor Imatinib with no recurrence 10 months post treatment. Conclusion: Gastrointestinal stromal tumor may be considered when presented with a recurrent tongue mass despite complete surgical resection. Surgical removal is curative for most lesions. Post-operative chemotherapy with the use of Imatinib is valuable. Keywords: recurrent tongue mass, gastrointestinal stromal tumor, immunohistochemistry, c-kit tyrosine kinase inhibitor

scholarly journals Antitumor Effect of the Tyrosine Kinase Inhibitor Nilotinib on Gastrointestinal Stromal Tumor (GIST) and Imatinib-Resistant GIST Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107613 ◽  
Author(s):  
Hiroyuki Sako ◽  
Kazumasa Fukuda ◽  
Yoshiro Saikawa ◽  
Rieko Nakamura ◽  
Tsunehiro Takahashi ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Gastrointestinal Stromal Tumor ◽  
Tyrosine Kinase Inhibitor ◽  
Antitumor Effect ◽  
Kinase Inhibitor ◽  
Stromal Tumor ◽  
Imatinib Resistant
Sign in / Sign up

Export Citation Format

Share Document